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Evaluation of pathophysiology and clinical significance of ongoing myocardial damage in life-style related diseases

Research Project

Project/Area Number 24590712
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Laboratory medicine
Research InstitutionFujita Health University

Principal Investigator

11 11  藤田保健衛生大学, 医学部, 教授 (70222940)

Project Period (FY) 2012-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Keywords高血圧症 / 糖尿病 / 慢性腎臓病 / トロポニン / 心不全 / 高血圧 / 高感度トロポニン / 潜在性心筋障害 / 生活習慣病 / 心筋障害
Outline of Final Research Achievements

Recent studies have shown that ongoing myocardial damage diagnosed by high-sensitivity troponin measurements may be associated with cardiovascular events, particularly incident heart failure in general population. Ongoing myocardial damage diagnosed by high-sensitivity troponin T measurements was present in approximately 30% in 1012 outpatients with life-style related diseases such as hypertension, type 2 diabetes and/or chronic kidney disease. Also, the severity of ongoing myocardial damage correlated with age, number of coronary risk factors, left ventricular overload, inflammation, renal dysfunction, and renal tubular injury. Furthermore, the combination of high sensitivity-troponin T and N-terminal pro-B-type natriuretic peptide concentration, which are individually independently predictive of heart failure admission, may be useful in the risk stratification of incident heart failure in this population.

Report

(6 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (21 results)

All 2017 2016 2015 2014 2013 2012

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results,  Open Access: 2 results) Presentation (17 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Combination of high-sensitivity troponin I and N-terminal pro-B-type natriuretic peptide predicts future hospital admission for heart failure in high-risk hypertensive patients with preserved left ventricular ejection fraction2017

    • Author(s)
      Ryunosuke Okuyama
    • Journal Title

      Heart and Vessels

      Volume: 印刷中 Issue: 7 Pages: 880-892

    • DOI

      10.1007/s00380-017-0948-9

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Cardiovascular Events in Patients with Chronic Kidney Disease.2016

    • Author(s)
      Hasegawa M, Ishii J, Kitagawa F, Takahashi H, Sugiyama K, Tada M, Kanayama K, Takahashi K, Hayashi H, Koide S, Nakai S, Ozaki Y, Yuzawa Y.
    • Journal Title

      Biomed Res Int.

      Volume: Volume2016 Pages: 8761475-8761475

    • DOI

      10.1155/2016/8761475

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Urinary neutrophil gelatinase-associated lipocalin as a predictor of cardiovascular events in patients with chronic kidney disease2015

    • Author(s)
      Hasegawa M, Ishii J, Kitagawa F, et al.
    • Journal Title

      Heart Vessels

      Volume: 30 (1) Issue: 1 Pages: 81-88

    • DOI

      10.1007/s00380-013-0454-7

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Prognostic value of highly sensitive troponin T on cardiac events in patients with chronic kidney disease not on dialysis.2013

    • Author(s)
      Hasegawa M, Ishii J, Kitagawa F, et al.
    • Journal Title

      Heart Vessels

      Volume: 28(4) Pages: 473-479

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Combined Assessment of High-Sensitivity Troponin T and NT-proBNP Predicts Future Hospital Admission for Heart Failure in Patients with Non-Dialytic CKD2017

    • Author(s)
      Shigeru Matsui
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      石川県立音楽堂、金沢市、石川県
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Prognostic Value of Combination of High-Sensitivity Troponin I and NT-proBNP for Future Heart Failure Admission in High-Risk Hypertensive Patients2017

    • Author(s)
      Ryunosuke Okuyama
    • Organizer
      第81回日本循環器学会学術集会
    • Place of Presentation
      石川県立音楽堂、金沢市、石川県
    • Year and Date
      2017-03-17
    • Related Report
      2016 Annual Research Report
  • [Presentation] Combination of High-Sensitivity Troponin I and N-Terminal Pro-B-Type Natriuretic Peptide Predicts Future Hospital Admission for Heart Failure in High-Risk Hypertensive Patients with Preserved Left Ventricular Ejection Fraction2016

    • Author(s)
      Ryunosuke Okuyama
    • Organizer
      American Heart Association (AHA) Scientific Sessions 2016
    • Place of Presentation
      Ernest N. Morial Convention Center, New Orleans, Louisiana, USA
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Combined Assessment of High-Sensitive Troponin I and N-Terminal Pro-B-Type Natriuretic Peptide Improves Prediction of Cardiovascular Events in Outpatients with Diabetes2016

    • Author(s)
      Mori Y, Ishii J, Okuyama R, et al.
    • Organizer
      第80回日本循環器学会学術集会
    • Place of Presentation
      仙台国際センター
    • Year and Date
      2016-03-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Combined Assessment of High-Sensitive Troponin I and N-Terminal Pro-B-Type Natriuretic Peptide Levels Improves the Prediction of Cardiovascular Event in Outpatients with Hypertension2015

    • Author(s)
      Matsui S, Ishii J, Takahashi H, et al.
    • Organizer
      American Heart Association (AHA) 2015 Scientific Sessions
    • Place of Presentation
      Orlando, USA
    • Year and Date
      2015-11-07
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 糖尿病患者における心不全発生リスクの予測:高感度トロポニンIとN末端プロB型ナトリウム利尿ペプチッド組み合わせの有用性2015

    • Author(s)
      森義久、石井潤一、奥山龍之介、他。
    • Organizer
      第63回日本心臓病学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] Combination of High-Sensitive Troponin and N-Terminal Pro-B-Type Natriuretic Peptide Improves Prediction of Future Admission for Heart Failure in Hypertensive Patients2015

    • Author(s)
      Ishii J, Takahashi H, Okuyama R, et al.
    • Organizer
      第79回日本循環器学会学術集会
    • Place of Presentation
      大阪国際会議
    • Year and Date
      2015-04-24
    • Related Report
      2015 Research-status Report
  • [Presentation] 慢性腎臓病患者におけるガレクチン3規定因子に関する検討2014

    • Author(s)
      北川 文彦, 武田 淳, 久野 貴弘, 石川 隆志, 成瀬 寛之, 石井 潤一
    • Organizer
      日本臨床検査医学会学術集会 61回2014年11月22日~11月25日
    • Place of Presentation
      福岡国際会議場、福岡市、福岡県
    • Year and Date
      2014-11-22 – 2014-11-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Combined Assessment of N-Terminal Pro-B-Type Natriuretic Peptide and High-Sensitivity Troponin T Levels Improves the Prediction of Future Admission for Heart Failure in Outpatients with Hypertension and Preserved Left Ventricular Ejection Fraction2014

    • Author(s)
      Matsui S, Ishii J, Takahashi H, et al.
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago, IL
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Combined Assessment of High-Sensitive Troponin I and N-Terminal Pro-B-Type Natriuretic Peptide Levels Improves the Prediction of Future Admission for Heart Failure in Outpatients with Chronic Kidney Disease2014

    • Author(s)
      Ishii J, Takahashi H, Hasegawa M, et al.
    • Organizer
      American Heart Association Scientific Sessions 2014
    • Place of Presentation
      Chicago, IL
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] 糖尿病患者における心不全入院リスクと血清高感度トロポニンI濃度との関係2014

    • Author(s)
      成瀬 寛之, 石井 潤一, 奥山 龍之介
    • Organizer
      日本心臓病学会学術集会抄録 62回
    • Place of Presentation
      仙台国際センター、仙台市、宮城県
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Research-status Report
  • [Presentation] Prognostic Values of Combination of High-Sensitivity Cardiac Troponin I and B-Type Natriuretic Peptide in Outpatients with Chronic Kidney Disease2014

    • Author(s)
      Ishii J, Hasegawa M, Yuzawa Y, et al.
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Glomerular Filtration Rate (GFR) Estimated by Cystatin C-Based versus Creatinine-Based Equations for Predicting Mortality in Outpatients with Diabetes Mellitus2014

    • Author(s)
      Okuyama R, Ishii J, Suzuki A, et al.
    • Organizer
      第78回日本循環器学会学術集会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] Prognostic Value of Combination of High-Sensitivity Troponin T and B-Type Natriuretic Peptide in Outpatients with Type 2 Diabetes Mellitus2013

    • Author(s)
      Matsui S, Ishii J, Suzuki A, et al.
    • Organizer
      Scientific Sessions 2013 American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Glomerular Filtration Rate Estimated by Cystatin C-Based versus Creatinine-Based Equations for Predicting Mortality in Outpatients with Type 2 Diabetes Mellitus2013

    • Author(s)
      Okuyama R, Ishii J, Suzuki A, et al.
    • Organizer
      Scientific Sessions 2013 American Heart Association
    • Place of Presentation
      Dallas, USA
    • Related Report
      2013 Research-status Report
  • [Presentation] Clinical Significance of Urinary Concentration of Liver-Type Fatty Acid-Binding Protein in Outpatients with Type-2 Diabetes Mellitus,2013

    • Author(s)
      Matsui S, Ishii J, Suzuki A, Itoh M, Okuyama R, Hashimoto T, Hattori K, Naruse H, Motoyama S, Mori Y, Izawa H, Ozaki Y.
    • Organizer
      第77回日本循環器学会学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Research-status Report
  • [Presentation] 2型糖尿病患者のリスク評価における尿中L型脂肪酸結合蛋白濃度測定の有用性.2012

    • Author(s)
      橋本 踏青, 石井 潤一, 鈴木 敦司, 伊藤 光泰, 服部 晃左, 成瀬 寛之, 森 義久, 松井 茂, 尾崎 行男.
    • Organizer
      第60回日本心臓病学会学術集会
    • Place of Presentation
      富山
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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