Evaluation of pathophysiology and clinical significance of ongoing myocardial damage in life-style related diseases

2016 Fiscal Year Final Research Report

• Project/Area Number: 24590712
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Laboratory medicine
• Research Institution: Fujita Health University
• Principal Investigator: 11 11 藤田保健衛生大学, 医学部, 教授 (70222940)
• Project Period (FY): 2012-04-01 – 2017-03-31
• Keywords: 高血圧症 / 糖尿病 / 慢性腎臓病 / トロポニン / 心不全

Outline of Final Research Achievements

Recent studies have shown that ongoing myocardial damage diagnosed by high-sensitivity troponin measurements may be associated with cardiovascular events, particularly incident heart failure in general population. Ongoing myocardial damage diagnosed by high-sensitivity troponin T measurements was present in approximately 30% in 1012 outpatients with life-style related diseases such as hypertension, type 2 diabetes and/or chronic kidney disease. Also, the severity of ongoing myocardial damage correlated with age, number of coronary risk factors, left ventricular overload, inflammation, renal dysfunction, and renal tubular injury. Furthermore, the combination of high sensitivity-troponin T and N-terminal pro-B-type natriuretic peptide concentration, which are individually independently predictive of heart failure admission, may be useful in the risk stratification of incident heart failure in this population.

Free Research Field

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