Evaluation of pathophysiology and clinical significance of ongoing myocardial damage in life-style related diseases
| Project/Area Number |
24590712
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Fujita Health University |
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Principal Investigator |
11 11 藤田保健衛生大学, 医学部, 教授 (70222940)
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| Project Period (FY) |
2012-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2016: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2015: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 高血圧症 / 糖尿病 / 慢性腎臓病 / トロポニン / 心不全 / 高血圧 / 高感度トロポニン / 潜在性心筋障害 / 生活習慣病 / 心筋障害 |
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| Outline of Final Research Achievements |
Recent studies have shown that ongoing myocardial damage diagnosed by high-sensitivity troponin measurements may be associated with cardiovascular events, particularly incident heart failure in general population. Ongoing myocardial damage diagnosed by high-sensitivity troponin T measurements was present in approximately 30% in 1012 outpatients with life-style related diseases such as hypertension, type 2 diabetes and/or chronic kidney disease. Also, the severity of ongoing myocardial damage correlated with age, number of coronary risk factors, left ventricular overload, inflammation, renal dysfunction, and renal tubular injury. Furthermore, the combination of high sensitivity-troponin T and N-terminal pro-B-type natriuretic peptide concentration, which are individually independently predictive of heart failure admission, may be useful in the risk stratification of incident heart failure in this population.
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Report
(6 results)
Research Products
(21 results)
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[Journal Article] Plasma Neutrophil Gelatinase-Associated Lipocalin as a Predictor of Cardiovascular Events in Patients with Chronic Kidney Disease.2016
Author(s)
Hasegawa M, Ishii J, Kitagawa F, Takahashi H, Sugiyama K, Tada M, Kanayama K, Takahashi K, Hayashi H, Koide S, Nakai S, Ozaki Y, Yuzawa Y.
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Journal Title
Biomed Res Int.
Volume: Volume2016
Pages: 8761475-8761475
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] Clinical Significance of Urinary Concentration of Liver-Type Fatty Acid-Binding Protein in Outpatients with Type-2 Diabetes Mellitus,2013
Author(s)
Matsui S, Ishii J, Suzuki A, Itoh M, Okuyama R, Hashimoto T, Hattori K, Naruse H, Motoyama S, Mori Y, Izawa H, Ozaki Y.
Organizer
第77回日本循環器学会学術集会
Place of Presentation
横浜
Related Report
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