Comprehensive analysis for immunological characteristics of tumor and autoimmune diseases related with mineral particles and fibers
Project/Area Number |
24590770
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hygiene
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Research Institution | Kawasaki Medical School |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
OTSUKI Takemi 川崎医科大学, 医学部, 教授 (40160551)
TAKEI Naoko 川崎医科大学, 医学部, 助教 (00509276)
MATSUZAKI Hidenori 川崎医科大学, 医学部, 助教 (80335463)
LEE Suni 川崎医科大学, 医学部, 助教 (70414026)
FUJIMOTO Wataru 川崎医科大学, 医学部, 教授 (50165429)
HAYASHI Hiroaki 川崎医科大学, 医学部, 講師 (60388965)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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Keywords | アスベスト / シリカ / 悪性中皮腫 / 自己免疫 / 全身性強皮症 / T細胞 / NK細胞 / 石綿 / 珪肺 / 強皮症 / 免疫 / 珪酸 / 遊離ケイ酸 / 珪肺症 / 免疫機能 / 癌疾患 / 自己免疫疾患 |
Outline of Final Research Achievements |
It is a crucial issue to clarify immunological characteristics of malignant mesothelioma (MM) and systemic sclerosis (SSc), diseases related with exposure to asbestos and silica respectively, which the present study examined by using peripheral blood specimens. Both MM patients and pleural plaque-positive (PL) individuals showed some similar characteristics, but regulatory T cell (Treg) marker was high in MM and cytotoxic T lymphocyte (CTL) function was high PL as well as MM. Multiple regression analysis of immunological parameters calculated a valuable prediction formula for malignant mesothelioma, which showed good ROC curve. Th17 function was high in SSc, while Th cells in silicoais (SIL) showed high IL-1R1 expression, meaning a trend to Th17, and factor analysis of the parameters explained similarity and difference between SIL and SSc.
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Report
(4 results)
Research Products
(41 results)
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[Journal Article] Silica exposure and altered regulation of autoimmunity2014
Author(s)
Lee S, Matsuzaki H, Kumagai-Takei N, Yoshitome K, Maeda M, Chen Y, Kusaka M, Urakami K, Hayashi H, Fujimoto W, Nishimura Y, Otsuki T,
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Journal Title
Environ Health Prev Med
Volume: 19
Issue: 5
Pages: 322-9
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] 珪酸曝露による免疫影響2014
Author(s)
松崎秀紀, 前田恵, 林宏明, 武井直子, 李順姫, 吉留敬, 草加勝康, 浦上更三, 西村泰光, 兵藤文則, 大槻剛巳
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Journal Title
日本予防医学会雑誌
Volume: 9
Pages: 1-8
NAID
Related Report
Peer Reviewed
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[Journal Article] Alteration of cytoskeletal molecules in a human T cell line caused by continuous exposure to chrysotile asbestos.2013
Author(s)
Maeda, M., Chen, Y., Kumagai-Takei, N., Hayashi, H., Matsuzaki, H., Lee, S., Hiratsuka, JI., Nishimura, Y., Kimura, Y., Otsuki T.
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Journal Title
Immunobiology
Volume: (in press)
Issue: 9
Pages: 1184-91
DOI
Related Report
Peer Reviewed
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[Journal Article] Altered functions of alveolar macrophages and NK cells involved in asbestos-related diseases.2013
Author(s)
Nishimura, Y., Maeda, M.,Kumagai-Takei, N., Lee, S., Matsuzaki, H., Wada, Y., Nishiike-Wada, T., Iguchi, H., Otsuki, T.
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Journal Title
Environ. Health Prev. Med.
Volume: 18(3)
Issue: 3
Pages: 198-204
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Exploration of biomarkers for asbestos exposure and occurrence of malignant mesothelioma based on the immunological effects of asbestos2013
Author(s)
Matsuzaki H, Lee S, Kumagai-Takei N, Hayashi H, Miura Y, Chen Y, Maeda M, Yamamoto S, Hatayama T, Nishimura Y, Otsuki T
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Journal Title
J Postgenomics: Drug & Biomarker Dev
Volume: S2
Issue: 02
Pages: 1-6
DOI
Related Report
Peer Reviewed
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[Journal Article] Resistance to asbestos-induced apoptosis with continuous exposure to crocidolite ona human T cell.2012
Author(s)
Maeda, M., Yamamoto, S., Chen, Y.,Kumagai-Takei, N., Hayashi, H., Matsuzaki, H., Lee, S., Hatayama, T., Miyahara, N., Katoh, M., Hiratsuka, J., Nishimura, Y., Otsuki, T.
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Journal Title
Sci. Total Environ.
Volume: 429
Pages: 174-182
DOI
Related Report
Peer Reviewed
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[Presentation] 珪酸・アスベストの免疫影響
Author(s)
西村泰光,武井直子,李順姫,松崎秀紀,大槻剛巳
Organizer
第13回肺分子病態研究会
Place of Presentation
ホテルレオパレス博多 (福岡)
Related Report
Invited
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[Book] Malignant Mesothelioma2012
Author(s)
Nishimura Y, Maeda M, Kumagai-Takei N, Matsuzaki H, Lee S, Fukuoka K, Nakano T, Kishimoto T, Otsuki T
Publisher
InTech
Related Report