Evaluation of HbA1c as a diagnostic tool for diabetes in the community: a cross-sectional and longitudinal study
Project/Area Number |
24590796
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Public health/Health science
|
Research Institution | Kyushu University |
Principal Investigator |
MUKAI Naoko 九州大学, 医学(系)研究科(研究院), 講師 (90596826)
|
Co-Investigator(Kenkyū-buntansha) |
KIYOHARA Yutaka 九州大学大学院医学研究院, 環境医学分野, 教授 (80161602)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
|
Keywords | 糖尿病 / HbA1c / 糖尿病網膜症 / 頸動脈硬化 / 心血管病 / 疫学 / 久山町研究 / 頚動脈硬化 / 網膜症 |
Outline of Final Research Achievements |
We examined the optimal threshold of HbA1c for diagnosing diabetes based on the prevalence of diabetic retinopathy (DR) in community-dwelling Japanese subjects. As a result, the optimal threshold of HbA1c(NGSP) for DR was 6.1%, which is below the current diagnostic criterion for diabetes. In addition, we investigated the association of HbA1c with carotid intima-media thickness (IMT). The multivariable-adjusted geometric average of the maximum IMT increased significantly with elevating HbA1c levels in subjects with glucose intolerance. Using data from a follow-up study, we assessed the association between HbA1c levels and the development of cardiovascular disease (CVD). Elevated HbA1c levels were an independent risk factor for ischemic stroke and coronary heart disease, and the addition of HbA1c to the model with known CVD risk factors significantly improved the predictive ability of CVD.
|
Report
(4 results)
Research Products
(30 results)
-
[Journal Article] Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: the Hisayama Study.2014
Author(s)
Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y.
-
Journal Title
J Diabetes Invest
Volume: 5
Issue: 2
Pages: 162-169
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study.2014
Author(s)
Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y
-
Journal Title
J Am Geriatr Soc
Volume: 62
Issue: 7
Pages: 1224-1230
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
-
[Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study.2014
Author(s)
Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
-
Journal Title
Atherosclerosis
Volume: 233
Issue: 2
Pages: 343-348
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
-
[Journal Article] Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community2014
Author(s)
Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
-
Journal Title
Circulation Journal
Volume: 78
Issue: 2
Pages: 403-409
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
-
[Journal Article] Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study.2014
Author(s)
Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.
-
Journal Title
Cardiovasc Diabetol
Volume: 13
Issue: 1
Pages: 45-45
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study.2013
Author(s)
Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y.
-
Journal Title
Cardiovasc Diabetol
Volume: 12
Issue: 1
Pages: 164-164
DOI
Related Report
Peer Reviewed
-
[Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009).2013
Author(s)
Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y.
-
Journal Title
Circulation
Volume: 128
Issue: 11
Pages: 1198-1205
DOI
Related Report
Peer Reviewed
-
[Journal Article] Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study.2013
Author(s)
Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M, Kitazono T, Kiyohara Y.
-
Journal Title
Atherosclerosis
Volume: 231
Issue: 2
Pages: 261-267
DOI
Related Report
Peer Reviewed
-
[Journal Article] Magnesium intake decreases type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study.2013
Author(s)
Hata A, Doi Y, Ninomiya T, Mukai N, Hirakawa Y, Hata J, Ozawa M, Uchida K, Shirota T, Kitazono T, Kiyohara Y.
-
Journal Title
Diabet Med
Volume: 30
Issue: 12
Pages: 1487-1494
DOI
Related Report
Peer Reviewed
-
-
[Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study.2013
Author(s)
Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y.
-
Journal Title
Stroke
Volume: 44
Issue: 6
Pages: 1512-1517
DOI
Related Report
Peer Reviewed
-
[Journal Article] Gender differences in the association between metabolic syndrome and periodontal disease: the Hisayama Study.2013
Author(s)
Furuta M, Shimazaki Y, Takeshita T, Shibata Y, Akifusa S, Eshima N, Kiyohara Y, Ninomiya T, Hirakawa Y, Mukai N, Nagata M, Yamashita Y.
-
Journal Title
J Clin Periodontol
Volume: 40
Issue: 8
Pages: 743-752
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
[Presentation] 地域住民における血糖関連指標と頚動脈壁肥厚との関連:久山町研究2014
Author(s)
向井直子, 平川洋一郎, 二宮利治, 池田文恵, 秦 淳, 福原正代, 堀田多恵子, 古賀正史, 中村宇大, 康 東天, 北園孝成, 清原 裕
Organizer
第57回日本糖尿病学会年次学術集会
Place of Presentation
大阪市
Year and Date
2014-05-23
Related Report
-
-
-
-
-
-
-
-