Evaluation of HbA1c as a diagnostic tool for diabetes in the community: a cross-sectional and longitudinal study

• Project/Area Number: 24590796
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Public health/Health science
• Research Institution: Kyushu University
• Principal Investigator: MUKAI Naoko 九州大学, 医学(系)研究科(研究院), 講師 (90596826)
• Co-Investigator(Kenkyū-buntansha): KIYOHARA Yutaka 九州大学大学院医学研究院, 環境医学分野, 教授 (80161602)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 糖尿病 / HbA1c / 糖尿病網膜症 / 頸動脈硬化 / 心血管病 / 疫学 / 久山町研究 / 頚動脈硬化 / 網膜症

Outline of Final Research Achievements

We examined the optimal threshold of HbA1c for diagnosing diabetes based on the prevalence of diabetic retinopathy (DR) in community-dwelling Japanese subjects. As a result, the optimal threshold of HbA1c(NGSP) for DR was 6.1%, which is below the current diagnostic criterion for diabetes. In addition, we investigated the association of HbA1c with carotid intima-media thickness (IMT). The multivariable-adjusted geometric average of the maximum IMT increased significantly with elevating HbA1c levels in subjects with glucose intolerance. Using data from a follow-up study, we assessed the association between HbA1c levels and the development of cardiovascular disease (CVD). Elevated HbA1c levels were an independent risk factor for ischemic stroke and coronary heart disease, and the addition of HbA1c to the model with known CVD risk factors significantly improved the predictive ability of CVD.

Research Products

• [Journal Article] Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: the Hisayama Study. (2014)
  • Author(s): Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y.
  • Journal Title: J Diabetes Invest Volume: 5 Issue: 2 Pages: 162-169
  • DOI: 10.1111/jdi.12136
  • Peer Reviewed / Open Access
• [Journal Article] Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study. (2014)
  • Author(s): Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y
  • Journal Title: J Am Geriatr Soc Volume: 62 Issue: 7 Pages: 1224-1230
  • DOI: 10.1111/jgs.12887
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Low Ankle Brachial Index is Associated with an Increased Risk of Cardiovascular Disease: The Hisayama Study (2014)
  • Author(s): Kojima I, Ninomiya T, Hata J, Fukuhara M, Hirakawa Y, Mukai N, Yoshida D, Kitazono T, Kiyohara Y
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 21 Issue: 9 Pages: 966-973
  • DOI: 10.5551/jat.22608
  • NAID: 130004690937
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study. (2014)
  • Author(s): Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
  • Journal Title: Atherosclerosis Volume: 233 Issue: 2 Pages: 343-348
  • DOI: 10.1016/j.atherosclerosis.2014.01.005
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community (2014)
  • Author(s): Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
  • Journal Title: Circulation Journal Volume: 78 Issue: 2 Pages: 403-409
  • DOI: 10.1253/circj.CJ-13-0811
  • NAID: 130003382214
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study. (2014)
  • Author(s): Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.
  • Journal Title: Cardiovasc Diabetol Volume: 13 Issue: 1 Pages: 45-45
  • DOI: 10.1186/1475-2840-13-45
  • Peer Reviewed / Open Access
• [Journal Article] Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study. (2013)
  • Author(s): Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y.
  • Journal Title: Cardiovasc Diabetol Volume: 12 Issue: 1 Pages: 164-164
  • DOI: 10.1186/1475-2840-12-164
  • Peer Reviewed
• [Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009). (2013)
  • Author(s): Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y.
  • Journal Title: Circulation Volume: 128 Issue: 11 Pages: 1198-1205
  • DOI: 10.1161/circulationaha.113.002424
  • Peer Reviewed
• [Journal Article] Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study. (2013)
  • Author(s): Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M, Kitazono T, Kiyohara Y.
  • Journal Title: Atherosclerosis Volume: 231 Issue: 2 Pages: 261-267
  • DOI: 10.1016/j.atherosclerosis.2013.09.023
  • Peer Reviewed
• [Journal Article] Magnesium intake decreases ｔype 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study. (2013)
  • Author(s): Hata A, Doi Y, Ninomiya T, Mukai N, Hirakawa Y, Hata J, Ozawa M, Uchida K, Shirota T, Kitazono T, Kiyohara Y.
  • Journal Title: Diabet Med Volume: 30 Issue: 12 Pages: 1487-1494
  • DOI: 10.1111/dme.12250
  • Peer Reviewed
• [Journal Article] Temporal trends in sudden unexpected death in a general population: the Hisayama Study. (2013)
  • Author(s): Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y.
  • Journal Title: Am Heart J Volume: 165 Issue: 6 Pages: 932-938
  • DOI: 10.1016/j.ahj.2013.02.028
  • Peer Reviewed
• [Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study. (2013)
  • Author(s): Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y.
  • Journal Title: Stroke Volume: 44 Issue: 6 Pages: 1512-1517
  • DOI: 10.1161/strokeaha.111.000704
  • Peer Reviewed
• [Journal Article] Gender differences in the association between metabolic syndrome and periodontal disease: the Hisayama Study. (2013)
  • Author(s): Furuta M, Shimazaki Y, Takeshita T, Shibata Y, Akifusa S, Eshima N, Kiyohara Y, Ninomiya T, Hirakawa Y, Mukai N, Nagata M, Yamashita Y.
  • Journal Title: J Clin Periodontol Volume: 40 Issue: 8 Pages: 743-752
  • DOI: 10.1111/jcpe.12119
  • Peer Reviewed
• [Journal Article] Impact of eating rate on obesity and cardiovascular risk factors according to glucose tolerance status: the Fukuoka Diabetes Registry and the Hisayama Study (2013)
  • Author(s): Ohkuma T
  • Journal Title: Diabetologia Volume: 56 Issue: 1 Pages: 70-77
  • DOI: 10.1007/s00125-012-2746-3
  • Peer Reviewed
• [Journal Article] Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: the Hisayama study. (2013)
  • Author(s): Doi Y, Mukai N（5番目）, et al.
  • Journal Title: Diabetes Care Volume: 36 Issue: 1 Pages: 98-100
  • DOI: 10.2337/dc12-0166
  • Peer Reviewed
• [Journal Article] Cut-off values of fasting and post-load plasma glucose and HbA1c for predicting Type 2 diabetes in community-dwelling Japanese subjects (2012)
  • Author(s): Mukai N, Fukuhara M, Kiyohara Y(最後), 他5名
  • Journal Title: the Hisayama Study Volume: 29 Issue: 1 Pages: 99-106
  • DOI: 10.1111/j.1464-5491.2011.03378.x
  • Peer Reviewed
• [Journal Article] Two risk score models for predicting incident type 2 diabetes in Japanese. (2012)
  • Author(s): Doi Y, Mukai N（5番目）, et al.
  • Journal Title: Diabet Med Volume: 29 Issue: 1 Pages: 107-114
  • DOI: 10.1111/j.1464-5491.2011.03376.x
  • Peer Reviewed
• [Journal Article] Prevalence and causes of functional disability in an elderly general population of Japanese: the Hisayama Study. (2012)
  • Author(s): Yoshida D, Mukai N（7番目）, et al.
  • Journal Title: J Epidemiol Volume: 22 Pages: 222-229
  • NAID: 10030618141
  • Peer Reviewed
• [Journal Article] Insulin resistance and the development of cardiovascular disease in a Japanese community: the Hisayama Study. (2012)
  • Author(s): Gotoh S, Mukai N（5番目）, et al.
  • Journal Title: J Atheroscler Thromb Volume: 19 Pages: 977-985
  • NAID: 130004444559
  • Peer Reviewed
• [Journal Article] Association between glucose tolerance level and cancer death in a general Japanese population: the Hisayama Study. (2012)
  • Author(s): Hirakawa Y, Mukai N（3番目）, et al.
  • Journal Title: Am J Epidemiol Volume: 176 Issue: 10 Pages: 856-864
  • DOI: 10.1093/aje/kws178
  • Peer Reviewed
• [Presentation] 糖尿病合併症の時代的変遷 (2014)
  • Author(s): 向井直子
  • Organizer: 第61回日本臨床検査医学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-11-25
  • Invited
• [Presentation] 地域住民における血糖関連指標と頚動脈壁肥厚との関連：久山町研究 (2014)
  • Author(s): 向井直子, 平川洋一郎, 二宮利治, 池田文恵, 秦 淳, 福原正代, 堀田多恵子, 古賀正史, 中村宇大, 康 東天, 北園孝成, 清原 裕
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-05-23
• [Presentation] 糖尿病診断における血糖関連指標のカットオフ値とその有用性の検討：久山町研究
  • Author(s): 向井直子ら
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本市
• [Presentation] 地域住民における75g経口糖負荷試験に基づいたHbA1cによる糖尿病の診断基準の検証：久山町研究
  • Author(s): 向井直子ら
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜市
• [Presentation] 生活習慣と2型糖尿病―久山町研究の結果から
  • Author(s): 向井直子ら
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横山市
  • Invited
• [Presentation] わが国の地域一般住民におけるメタボリックシンドロームと 空腹時血糖異常の2型糖尿病発症に及ぼす影響の比較・検討： 久山町研究
  • Author(s): 向井直子ら
  • Organizer: 第9回九州先進糖尿病研究会
  • Place of Presentation: 福岡市
  • Invited
• [Presentation] 2型糖尿病の予知
  • Author(s): 向井直子ら
  • Organizer: 第47回糖尿病学の進歩
  • Place of Presentation: 四日市市
  • Invited
• [Remarks] 九州大学大学院医学研究院 環境医学分野
  • URL: http://www.envmed.med.kyushu-u.ac.jp/
• [Remarks] 九州大学大学院医学研究院環境医学分野
  • URL: http://www.envmed.med.kyushu-u.ac.jp/
• [Remarks] 九州大学大学院医学研究院環境医学分野
  • URL: http://www.envmed.med.kyushu-u.ac.jp/