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Evaluation of HbA1c as a diagnostic tool for diabetes in the community: a cross-sectional and longitudinal study

Research Project

Project/Area Number 24590796
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Public health/Health science
Research InstitutionKyushu University

Principal Investigator

MUKAI Naoko  九州大学, 医学(系)研究科(研究院), 講師 (90596826)

Co-Investigator(Kenkyū-buntansha) KIYOHARA Yutaka  九州大学大学院医学研究院, 環境医学分野, 教授 (80161602)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Keywords糖尿病 / HbA1c / 糖尿病網膜症 / 頸動脈硬化 / 心血管病 / 疫学 / 久山町研究 / 頚動脈硬化 / 網膜症
Outline of Final Research Achievements

We examined the optimal threshold of HbA1c for diagnosing diabetes based on the prevalence of diabetic retinopathy (DR) in community-dwelling Japanese subjects. As a result, the optimal threshold of HbA1c(NGSP) for DR was 6.1%, which is below the current diagnostic criterion for diabetes. In addition, we investigated the association of HbA1c with carotid intima-media thickness (IMT). The multivariable-adjusted geometric average of the maximum IMT increased significantly with elevating HbA1c levels in subjects with glucose intolerance. Using data from a follow-up study, we assessed the association between HbA1c levels and the development of cardiovascular disease (CVD). Elevated HbA1c levels were an independent risk factor for ischemic stroke and coronary heart disease, and the addition of HbA1c to the model with known CVD risk factors significantly improved the predictive ability of CVD.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (30 results)

All 2014 2013 2012 Other

All Journal Article (20 results) (of which Peer Reviewed: 20 results,  Open Access: 4 results,  Acknowledgement Compliant: 4 results) Presentation (7 results) (of which Invited: 4 results) Remarks (3 results)

  • [Journal Article] Trends in the prevalence of type 2 diabetes and prediabetes in community-dwelling Japanese subjects: the Hisayama Study.2014

    • Author(s)
      Mukai N, Doi Y, Ninomiya T, Hirakawa Y, Nagata M, Yoshida D, Hata J, Fukuhara M, Nakamura U, Kitazono T, Kiyohara Y.
    • Journal Title

      J Diabetes Invest

      Volume: 5 Issue: 2 Pages: 162-169

    • DOI

      10.1111/jdi.12136

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Milk and dairy consumption and risk of dementia in an elderly Japanese population: the Hisayama Study.2014

    • Author(s)
      Ozawa M, Ohara T, Ninomiya T, Hata J, Yoshida D, Mukai N, Nagata M, Uchida K, Shirota T, Kitazono T, Kiyohara Y
    • Journal Title

      J Am Geriatr Soc

      Volume: 62 Issue: 7 Pages: 1224-1230

    • DOI

      10.1111/jgs.12887

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] A Low Ankle Brachial Index is Associated with an Increased Risk of Cardiovascular Disease: The Hisayama Study2014

    • Author(s)
      Kojima I, Ninomiya T, Hata J, Fukuhara M, Hirakawa Y, Mukai N, Yoshida D, Kitazono T, Kiyohara Y
    • Journal Title

      Journal of Atherosclerosis and Thrombosis

      Volume: 21 Issue: 9 Pages: 966-973

    • DOI

      10.5551/jat.22608

    • NAID

      130004690937

    • ISSN
      1340-3478, 1880-3873
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Non-high-density lipoprotein cholesterol and the development of coronary heart disease and stroke subtypes in a general Japanese population: the Hisayama Study.2014

    • Author(s)
      Imamura T, Doi Y, Ninomiya T, Hata J, Nagata M, Ikeda F, Mukai N, Hirakawa Y, Yoshida D, Fukuhara M, Kitazono T, Kiyohara Y
    • Journal Title

      Atherosclerosis

      Volume: 233 Issue: 2 Pages: 343-348

    • DOI

      10.1016/j.atherosclerosis.2014.01.005

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Trends in the Incidence and Survival of Intracerebral Hemorrhage by its Location in a Japanese Community2014

    • Author(s)
      Gotoh S, Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Fukuhara M, Ikeda F, Shikata K, Kamouchi M, Kitazono T, Kiyohara Y
    • Journal Title

      Circulation Journal

      Volume: 78 Issue: 2 Pages: 403-409

    • DOI

      10.1253/circj.CJ-13-0811

    • NAID

      130003382214

    • ISSN
      1346-9843, 1347-4820
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Thresholds of various glycemic measures for diagnosing diabetes based on prevalence of retinopathy in community-dwelling Japanese subjects: the Hisayama Study.2014

    • Author(s)
      Mukai N, Yasuda M, Ninomiya T, Hata J, Hirakawa Y, Ikeda F, Fukuhara M, Hotta T, Koga M, Nakamura U, Kang D, Kitazono T, Kiyohara Y.
    • Journal Title

      Cardiovasc Diabetol

      Volume: 13 Issue: 1 Pages: 45-45

    • DOI

      10.1186/1475-2840-13-45

    • Related Report
      2013 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Haemoglobin A1c even within non-diabetic level is a predictor of cardiovascular disease in a general Japanese population: the Hisayama Study.2013

    • Author(s)
      Ikeda F, Doi Y, Ninomiya T, Hirakawa Y, Mukai N, Hata J, Shikata K, Yoshida D, Matsumoto T, Kitazono T, Kiyohara Y.
    • Journal Title

      Cardiovasc Diabetol

      Volume: 12 Issue: 1 Pages: 164-164

    • DOI

      10.1186/1475-2840-12-164

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Secular trends in cardiovascular disease and its risk factors in Japanese: half-century data from the Hisayama Study (1961-2009).2013

    • Author(s)
      Hata J, Ninomiya T, Hirakawa Y, Nagata M, Mukai N, Gotoh S, Fukuhara M, Ikeda F, Shikata K, Yoshida D, Yonemoto K, Kamouchi M, Kitazono T, Kiyohara Y.
    • Journal Title

      Circulation

      Volume: 128 Issue: 11 Pages: 1198-1205

    • DOI

      10.1161/circulationaha.113.002424

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between ratio of serum eicosapentaenoic acid to arachidonic acid and risk of cardiovascular disease: the Hisayama Study.2013

    • Author(s)
      Ninomiya T, Nagata M, Hata J, Hirakawa Y, Ozawa M, Yoshida D, Ohara T, Kishimoto H, Mukai N, Fukuhara M, Kitazono T, Kiyohara Y.
    • Journal Title

      Atherosclerosis

      Volume: 231 Issue: 2 Pages: 261-267

    • DOI

      10.1016/j.atherosclerosis.2013.09.023

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Magnesium intake decreases type 2 diabetes risk through the improvement of insulin resistance and inflammation: the Hisayama Study.2013

    • Author(s)
      Hata A, Doi Y, Ninomiya T, Mukai N, Hirakawa Y, Hata J, Ozawa M, Uchida K, Shirota T, Kitazono T, Kiyohara Y.
    • Journal Title

      Diabet Med

      Volume: 30 Issue: 12 Pages: 1487-1494

    • DOI

      10.1111/dme.12250

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Temporal trends in sudden unexpected death in a general population: the Hisayama Study.2013

    • Author(s)
      Nagata M, Ninomiya T, Doi Y, Hata J, Ikeda F, Mukai N, Tsuruya K, Oda Y, Kitazono T, Kiyohara Y.
    • Journal Title

      Am Heart J

      Volume: 165 Issue: 6 Pages: 932-938

    • DOI

      10.1016/j.ahj.2013.02.028

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] White-coat and masked hypertension are associated with carotid atherosclerosis in a general population: the Hisayama Study.2013

    • Author(s)
      Fukuhara M, Arima H, Ninomiya T, Hata J, Hirakawa Y, Doi Y, Yonemoto K, Mukai N, Nagata M, Ikeda F, Matsumura K, Kitazono T, Kiyohara Y.
    • Journal Title

      Stroke

      Volume: 44 Issue: 6 Pages: 1512-1517

    • DOI

      10.1161/strokeaha.111.000704

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gender differences in the association between metabolic syndrome and periodontal disease: the Hisayama Study.2013

    • Author(s)
      Furuta M, Shimazaki Y, Takeshita T, Shibata Y, Akifusa S, Eshima N, Kiyohara Y, Ninomiya T, Hirakawa Y, Mukai N, Nagata M, Yamashita Y.
    • Journal Title

      J Clin Periodontol

      Volume: 40 Issue: 8 Pages: 743-752

    • DOI

      10.1111/jcpe.12119

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impact of eating rate on obesity and cardiovascular risk factors according to glucose tolerance status: the Fukuoka Diabetes Registry and the Hisayama Study2013

    • Author(s)
      Ohkuma T
    • Journal Title

      Diabetologia

      Volume: 56 Issue: 1 Pages: 70-77

    • DOI

      10.1007/s00125-012-2746-3

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Angiopoietin-like protein 2 and risk of type 2 diabetes in a general Japanese population: the Hisayama study.2013

    • Author(s)
      Doi Y, Mukai N(5番目), et al.
    • Journal Title

      Diabetes Care

      Volume: 36 Issue: 1 Pages: 98-100

    • DOI

      10.2337/dc12-0166

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cut-off values of fasting and post-load plasma glucose and HbA1c for predicting Type 2 diabetes in community-dwelling Japanese subjects2012

    • Author(s)
      Mukai N, Fukuhara M, Kiyohara Y(最後), 他5名
    • Journal Title

      the Hisayama Study

      Volume: 29 Issue: 1 Pages: 99-106

    • DOI

      10.1111/j.1464-5491.2011.03378.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Two risk score models for predicting incident type 2 diabetes in Japanese.2012

    • Author(s)
      Doi Y, Mukai N(5番目), et al.
    • Journal Title

      Diabet Med

      Volume: 29 Issue: 1 Pages: 107-114

    • DOI

      10.1111/j.1464-5491.2011.03376.x

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Prevalence and causes of functional disability in an elderly general population of Japanese: the Hisayama Study.2012

    • Author(s)
      Yoshida D, Mukai N(7番目), et al.
    • Journal Title

      J Epidemiol

      Volume: 22 Pages: 222-229

    • NAID

      10030618141

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Insulin resistance and the development of cardiovascular disease in a Japanese community: the Hisayama Study.2012

    • Author(s)
      Gotoh S, Mukai N(5番目), et al.
    • Journal Title

      J Atheroscler Thromb

      Volume: 19 Pages: 977-985

    • NAID

      130004444559

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association between glucose tolerance level and cancer death in a general Japanese population: the Hisayama Study.2012

    • Author(s)
      Hirakawa Y, Mukai N(3番目), et al.
    • Journal Title

      Am J Epidemiol

      Volume: 176 Issue: 10 Pages: 856-864

    • DOI

      10.1093/aje/kws178

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 糖尿病合併症の時代的変遷2014

    • Author(s)
      向井直子
    • Organizer
      第61回日本臨床検査医学会学術集会
    • Place of Presentation
      福岡市
    • Year and Date
      2014-11-25
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 地域住民における血糖関連指標と頚動脈壁肥厚との関連:久山町研究2014

    • Author(s)
      向井直子, 平川洋一郎, 二宮利治, 池田文恵, 秦 淳, 福原正代, 堀田多恵子, 古賀正史, 中村宇大, 康 東天, 北園孝成, 清原 裕
    • Organizer
      第57回日本糖尿病学会年次学術集会
    • Place of Presentation
      大阪市
    • Year and Date
      2014-05-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糖尿病診断における血糖関連指標のカットオフ値とその有用性の検討:久山町研究

    • Author(s)
      向井直子ら
    • Organizer
      第56回日本糖尿病学会年次学術集会
    • Place of Presentation
      熊本市
    • Related Report
      2013 Research-status Report
  • [Presentation] 地域住民における75g経口糖負荷試験に基づいたHbA1cによる糖尿病の診断基準の検証:久山町研究

    • Author(s)
      向井直子ら
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜市
    • Related Report
      2012 Research-status Report
  • [Presentation] 生活習慣と2型糖尿病―久山町研究の結果から

    • Author(s)
      向井直子ら
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横山市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] わが国の地域一般住民におけるメタボリックシンドロームと 空腹時血糖異常の2型糖尿病発症に及ぼす影響の比較・検討: 久山町研究

    • Author(s)
      向井直子ら
    • Organizer
      第9回九州先進糖尿病研究会
    • Place of Presentation
      福岡市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Presentation] 2型糖尿病の予知

    • Author(s)
      向井直子ら
    • Organizer
      第47回糖尿病学の進歩
    • Place of Presentation
      四日市市
    • Related Report
      2012 Research-status Report
    • Invited
  • [Remarks] 九州大学大学院医学研究院 環境医学分野

    • URL

      http://www.envmed.med.kyushu-u.ac.jp/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 九州大学大学院医学研究院環境医学分野

    • URL

      http://www.envmed.med.kyushu-u.ac.jp/

    • Related Report
      2013 Research-status Report
  • [Remarks] 九州大学大学院医学研究院環境医学分野

    • URL

      http://www.envmed.med.kyushu-u.ac.jp/

    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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