TGF-beta1 is associated with the progression of intracranial deep white matter lesions: a pilot study with 5 years of MRI evaluation
| Project/Area Number |
24590809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KURIYAMA Nagato 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60405264)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yoshiyuki 京都府立医科大学, 大学院医学研究科, 教授 (00191809)
OZAKI Etsuko 京都府立医科大学, 大学院医学研究科, 助教 (00438219)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUNO Toshiki 京都府立医科大学, 大学院医学研究科, 教授 (30264782)
YAMADA Kei 京都府立医科大学, 大学院医学研究科, 教授 (80315960)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | TGF-beta1 / サイトカイン / 脳内深部白質病変 / 慢性炎症 / TGF-β１ / 慢性腎臓病 / TGFβ1 / 認知機能低下 / 血管性性認知症 / 前向き調査研究 / 軽度認知機能障害 / TGFβ-１ / 頭部MRI 検査 / 10年間の追跡調査 / 虚血性深部白質病変 |
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| Outline of Final Research Achievements |
Elevated expression of transforming growth factor (TGF)-beta1 has been reported in hereditary cerebral small-vessel (HCSV) disease. The aim of this study was to clarify whether TGF-beta1 is a risk factor for intracranial deep white matter lesions (DWLs) and their progression(progression of DWL) (DWLP)in a general elderly population.The subjects included 81 participants with brain MRI in 2003 and 2008.The highest TGF-beta1 levels were found in Group DWLP.The TGF-beta1 levels were significantly higher in Group DWLP than in Group DWL, and DWLP was ｓignificantly correlated with elevated TGF-beta1 levels (odds ratio: 1.72). Chronic kidbey disease might be involved in the pathogenesis of progression of DWLs and elevated TGF-β1. Our data suggest that TGF-beta1 is expected to be useful as a clinical indicator reflecting the presence ofintracranial white matter lesions or concomitant vascular cognitive decline.
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Report
(4 results)
Research Products
(5 results)
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[Journal Article] TGF-beta1 is associated with the progression of intracranial deep white matter lesions: a pilot study with 5 years of magnetic resonance imaging follow-up.2014
Author(s)
Kuriyama N, Mizuno T, Kita M, Yamada K, Ozaki E, Matsumoto S, Takada A, Watanabe A, Kasai T, Nagakane Y, Mitani S, Matsui D, Watanabe I, Takeda K, Nakagawa M, Watanabe Y.
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Journal Title
Neurol Res.
Volume: 36
Issue: 1
Pages: 47-52
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] TGF-beta1 is associated with the progression of intracranial deep white matter lesions: a pilot study with 5 years of magnetic resonance imaging follow-up.2013
Author(s)
Kuriyama N，Mizuno T, Kita M, Yamada K, Ozaki E, Matsumoto S, Takada A, Watanabe A, Kasai T, Nagakane Y, Mitani S, Matsui D, Watanabe I, Takeda K, Nakagawa M, Watanabe Y.
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Journal Title
Neurol Res.
Volume: 36
Pages: 47-52
Related Report
Peer Reviewed
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[Journal Article] Intracranial deep white matter lesions (DWLs) are associated with chronic kidney disease (CKD) and cognitive impairment: A 5-year follow-up magnetic resonance imaging (MRI) study.2013
Author(s)
Kuriyama N, Mizuno T, Ohshima Y, Yamada K, Ozaki E, Shigeta M, Mitani S, Kondo M, Matsumoto S, Takeda K, Nakagawa M, Watanabe Y.
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Journal Title
Arch Gerontol Geriatr.
Volume: 56
Pages: 55-60
Related Report
Peer Reviewed
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