| Project/Area Number |
24590809
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
KURIYAMA Nagato 京都府立医科大学, 医学(系)研究科(研究院), 准教授 (60405264)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Yoshiyuki 京都府立医科大学, 大学院医学研究科, 教授 (00191809)
OZAKI Etsuko 京都府立医科大学, 大学院医学研究科, 助教 (00438219)
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| Co-Investigator(Renkei-kenkyūsha) |
MIZUNO Toshiki 京都府立医科大学, 大学院医学研究科, 教授 (30264782)
YAMADA Kei 京都府立医科大学, 大学院医学研究科, 教授 (80315960)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | TGF-beta1 / サイトカイン / 脳内深部白質病変 / 慢性炎症 / TGF-β１ / 慢性腎臓病 / TGFβ1 / 認知機能低下 / 血管性性認知症 / 前向き調査研究 / 軽度認知機能障害 / TGFβ-１ / 頭部MRI 検査 / 10年間の追跡調査 / 虚血性深部白質病変 |
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| Outline of Final Research Achievements |
Elevated expression of transforming growth factor (TGF)-beta1 has been reported in hereditary cerebral small-vessel (HCSV) disease. The aim of this study was to clarify whether TGF-beta1 is a risk factor for intracranial deep white matter lesions (DWLs) and their progression(progression of DWL) (DWLP)in a general elderly population.The subjects included 81 participants with brain MRI in 2003 and 2008.The highest TGF-beta1 levels were found in Group DWLP.The TGF-beta1 levels were significantly higher in Group DWLP than in Group DWL, and DWLP was ｓignificantly correlated with elevated TGF-beta1 levels (odds ratio: 1.72). Chronic kidbey disease might be involved in the pathogenesis of progression of DWLs and elevated TGF-β1. Our data suggest that TGF-beta1 is expected to be useful as a clinical indicator reflecting the presence ofintracranial white matter lesions or concomitant vascular cognitive decline.
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