| Project/Area Number |
24590844
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Hyogo Medical University (2014)
Foundation for Biomedical Research and Innovation (2012-2013) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Tomonori 慶應義塾大学, 医学部, 教授 (00324567)
HIGASHIYAMA Aya 国立循環器病研究センター, 研究開発基盤センター, 室長 (20533003)
KADOTA Aya 滋賀医科大学, アジア疫学研究センター, 特任准教授 (60546068)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 疫学調査 / 動脈硬化予防 / LDL酸化 / 都市部住民 / 農村部住民 |
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| Outline of Final Research Achievements |
In the Kobe study, the cohort study of urban residents, we measured serum tocopherols as a dietary factor. We reported in the academic conference that suggested that dietary vitamin E may be associated with lower oxidized low-density lipoprotein (Ox-LDL) and suppression of endothelial dysfunction. Other reports in the academic conferences were: the salt intake, taste recognition of salt and blood pressure; Ox-LDL and overweight or obesity. Furthermore, the original article was accepted for publication in J Nutr Health Aging. We examined the association between serum polyunsaturated fatty acids (as dietary factor) and systemic inflammation (Ox-LDL is known to be involved in) in the article. In the Sasayama study, the cohort study of rural residents, we measured Ox-LDL and urinary L-FABP (it is associated with oxidative stress and microvascular angiopathy). We also surveyed detail lifestyle factors in the Sasayama study and continuously progress the research findings.
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