Lifestyle factors on preventing oxidized LDL-cholesterol in urban residents
| Project/Area Number |
24590844
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Hyogo Medical University (2014)
Foundation for Biomedical Research and Innovation (2012-2013) |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
OKAMURA Tomonori 慶應義塾大学, 医学部, 教授 (00324567)
HIGASHIYAMA Aya 国立循環器病研究センター, 研究開発基盤センター, 室長 (20533003)
KADOTA Aya 滋賀医科大学, アジア疫学研究センター, 特任准教授 (60546068)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 疫学調査 / 動脈硬化予防 / LDL酸化 / 都市部住民 / 農村部住民 |
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| Outline of Final Research Achievements |
In the Kobe study, the cohort study of urban residents, we measured serum tocopherols as a dietary factor. We reported in the academic conference that suggested that dietary vitamin E may be associated with lower oxidized low-density lipoprotein (Ox-LDL) and suppression of endothelial dysfunction. Other reports in the academic conferences were: the salt intake, taste recognition of salt and blood pressure; Ox-LDL and overweight or obesity. Furthermore, the original article was accepted for publication in J Nutr Health Aging. We examined the association between serum polyunsaturated fatty acids (as dietary factor) and systemic inflammation (Ox-LDL is known to be involved in) in the article. In the Sasayama study, the cohort study of rural residents, we measured Ox-LDL and urinary L-FABP (it is associated with oxidative stress and microvascular angiopathy). We also surveyed detail lifestyle factors in the Sasayama study and continuously progress the research findings.
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Report
(4 results)
Research Products
(26 results)
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[Journal Article] The Relationship between Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1 Ligands Containing Apolipoprotein B and the Cardio-Ankle Vascular Index in Healthy Community Inhabitants: The KOBE Study2015
Author(s)
Sugiyama D, Higashiyama A, Wakabayashi I, Kubota Y, Adachi Y, Hayashibe A, Kawamura K, Kuwabara K, Nishimura K, Kadota A, Nishida Y, Hirata T, Imano H, Miyamatsu N, Miyamoto Y, Sawamura T, Okamura T.
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Journal Title
Journal of Atherosclerosis and Thrombosis
Volume: 22
Issue: 5
Pages: 499-508
DOI
NAID
ISSN
1340-3478, 1880-3873
Related Report
Peer Reviewed / Open Access
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[Journal Article] HOMA-IR values are associated with glycemic control in Japanese subjects without diabetes or obesity: the KOBE Study.2015
Author(s)
Hirata T, Higashiyama A, Kubota Y, Nishimura K, Sugiyama D, Kadota A, Nishida Y, Imano H, Nishikawa T, Miyamatsu N, Miyamoto Y, Okamura T.
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Journal Title
NAID
Related Report
Peer Reviewed
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[Journal Article] Does High-Sensitivity C-Reactive Protein or Low-Density Lipoprotein Cholesterol Show a Stronger Relationship with the Cardio-Ankle Vascular Index in Healthy Community Dwellers?: the KOBE Study2012
Author(s)
Higashiyama A, Wakabayashi I, Kubota Y, Adachi Y, Hayashibe A, Nishimura K, Sugiyama D, Kadota A, Imano H, Miyamatsu N, Miyamoto Y, Okamura T.
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Journal Title
J Atheroscler Thromb
Volume: 19
Pages: 1027-1034
NAID
Related Report
Peer Reviewed
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