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The mechanism of myocardial injury from heat exposure

Research Project

Project/Area Number 24590853
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionMie University

Principal Investigator

NATA Masayuki  三重大学, 医学(系)研究科(研究院), 教授 (70241627)

Research Collaborator NAKAGAWA Yasuhisa  
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords熱中症 / 心疾患 / 心筋梗塞 / 心筋傷害 / 低酸素 / 虚血 / 高温曝露 / 心臓 / 直接的傷害 / 高温暴露
Outline of Final Research Achievements

Cardiac deisease is the one of the risk factor of onset of heat stroke. However, its detailed mechanisms have yet to be revealed. Therefore, We exposed heat to myocardial infarction rats, and investigated the relationship between cardiac disease and heat exposure.
In this investigation, it revealed immediately direct injury to myocardium from heat exposure. And also, it revealed possibilities that after heat exposure, heart strain from myocardial injury and myocardial ischemia are continued. In the case of cardiac disease, it is sensitive to heat exposure, and associated with a great risk of onset and exacerbation of heat stroke.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013 2012 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] Does methanphetamine affect bone metabolism?2014

    • Author(s)
      Tomita M, Katsuyama H, Watanabe Y, Okuyama T, Fushimi S, Ishikawa T, Nata M, Miyamoto O.
    • Journal Title

      Toxicology

      Volume: 319 Pages: 63-68

    • DOI

      10.1016/j.tox.2014.01.014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cardiotoxicity of methamphetamine under stress conditions: Comparison of single dose and long-term use2013

    • Author(s)
      M. Tomita, T. Okuyama, H. Katsuyama, Y. Watanabe, K. Shinone, M. Nata, T. Ishikawa
    • Journal Title

      Mol. Med. Rep

      Volume: 7 Issue: 6 Pages: 1786-1790

    • DOI

      10.3892/mmr.2013.1408

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular-biological analysis of acute lung injury (ALI) induced by heat exposure and/or intravenous administration of oleic acid2012

    • Author(s)
      Hiromasa Inoue
    • Journal Title

      Legal Medicine

      Volume: 14 Issue: 6 Pages: 304-308

    • DOI

      10.1016/j.legalmed.2012.06.003

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Molecular biological analysis of cardiac effect of high temperature in rats.2012

    • Author(s)
      Nakagawa Y, Inoue H, Shinone K, Ikemura M, Nata M.
    • Journal Title

      Leg Med

      Volume: 14 Issue: 2 Pages: 63-68

    • DOI

      10.1016/j.legalmed.2011.12.001

    • Related Report
      2012 Research-status Report
  • [Journal Article] The blood concentration and organ distribution of haloperidol at therapeutic and toxic doses in severe fatty liver disease2012

    • Author(s)
      Mayumi Ikemura
    • Journal Title

      Legal Medicine

      Volume: 14 Issue: 3 Pages: 147-153

    • DOI

      10.1016/j.legalmed.2012.01.012

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 心疾患は高温暴露に対して脆弱か?(心筋梗塞モデルラットを用いた高温暴露の分子病態学的検討)2015

    • Author(s)
      中川泰久, 山本好男, 小澤周二, 池村真弓, 清藤佑馬, 那谷雅之
    • Organizer
      第99次日本法医学会全国集会
    • Place of Presentation
      高知市 高知市文化プラザ かるぽーと
    • Year and Date
      2015-06-10 – 2015-06-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] スポーツ飲料摂取後における熱暴露による脳幹への影響の分子病態学的検討2014

    • Author(s)
      清藤佑馬, 中川泰久, 井上裕匡, 池村真弓, 小澤周二, 那谷雅之
    • Organizer
      第98次日本法医学会全国集会
    • Place of Presentation
      福岡市 福岡国際センター
    • Year and Date
      2014-06-16 – 2014-06-20
    • Related Report
      2014 Annual Research Report
  • [Presentation] スポーツ飲料摂取語の熱暴露による脳幹への影響の分子病態学的検討2013

    • Author(s)
      清藤祐馬、中川泰久、井上裕匡、池村真弓、臼杵恵梨、那谷雅之
    • Organizer
      第20階日本未病システム学会学術総会
    • Place of Presentation
      東京都 学術総合センター(一橋大学一橋講堂)
    • Related Report
      2013 Research-status Report
  • [Presentation] 電解質飲料摂取後の高温暴露に基づく脳幹の分子病態学的検討2013

    • Author(s)
      清藤祐馬、中川泰久、井上裕匡、池村真弓、臼杵恵梨、那谷雅之
    • Organizer
      第97次日本法医学会学術全国集会
    • Place of Presentation
      札幌市 ロイトン札幌
    • Related Report
      2013 Research-status Report
  • [Presentation] Serotonin syndromeモデルラットを用いたFluvoxamineの心保護作用とそのメカニズムの検討

    • Author(s)
      臼杵恵梨、中川泰久、池村真弓、井上裕匡、清藤祐馬、那谷雅之
    • Organizer
      第35回日本法医学会学術中部地方集会
    • Place of Presentation
      金沢市 金沢医科大学病院
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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