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Autopsy diagnosis of deaths due to overdoses of insulin: development of detection methods of insulin formulations

Research Project

Project/Area Number 24590873
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Legal medicine
Research InstitutionFukuoka University

Principal Investigator

KASHIWAGI Masayuki  福岡大学, 医学部, 准教授 (70301687)

Co-Investigator(Kenkyū-buntansha) HARA Kenji  福岡大学, 医学部, 講師 (00090738)
WATERS Brian  福岡大学, 医学部, 助教 (00609480)
KUBO Shin-ichi  福岡大学, 医学部, 教授 (10205122)
Project Period (FY) 2012-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsインスリン / GC-MS / LC-MS/MS / 低血糖症 / GC/MS / LC/MS/MS
Outline of Final Research Achievements

During this study period, meta-cresol, one of the additives in insulin formulations, could be detected with a head space-solid phase micro extraction (HS-SPME) method using gas chromatography-tandem mass spectrometry (GC-MS/MS), and quantitation was believed to be achievable by the application of the method. For insulin analogues, detection was possible using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and quantitation was also considered a possibility.

Report

(5 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (2 results)

All 2013 Other

All Int'l Joint Research (1 results) Presentation (1 results)

  • [Int'l Joint Research] マインツ大学法医学研究所(ドイツ)

    • Related Report
      2015 Annual Research Report
  • [Presentation] 法医学領域における質量分析の最新応用―執刀者の立場から―2013

    • Author(s)
      柏木正之、久保真一
    • Organizer
      第38回日本医用マススペクトル学会年会
    • Place of Presentation
      神戸市産業振興センター
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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