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Study of the function of Aig1l protein and the mechanism of acupuncture

Research Project

Project/Area Number 24590884
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field General internal medicine (including Psychosomatic medicine)
Research InstitutionKobe University

Principal Investigator

OHTA Mika  神戸大学, 医学部附属病院, 学術研究員 (20274706)

Co-Investigator(Kenkyū-buntansha) TAKOKA Yutaka  神戸大学, 医学部附属病院, 准教授 (20332281)
ICHINOSE Akihiro  神戸大学, 医学部附属病院, 特命准教授 (90362780)
Research Collaborator SUGANO Aki  神戸大学, 医学部附属病院, 特命助教 (20457039)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords東洋医学 / 鍼治療 / Aig1l / ホモロジーモデリング法 / フラグメントアセンブリ法 / 立体構造解析 / フラグメントアセンブリ / 鍼通電
Outline of Final Research Achievements

We previously found acupuncture-induced 1-L (Aig1l) gene and determined the full-length cDNA (Genbank accession no. DQ167195). Our aim is to elucidate the function of Aig1l protein and the mechanism of acupuncture therapy in this study. We used synthetic peptides as antigens and produced five anti-Aig1l antibodies. We obtained a specific antibody from those antibodies. The tertiary structure of Aig1l protein's 217-895 amino acids from N-terminus (679 out of 962 amino acids) was constructed by using homology modeling method and fragment assembly method. We then observed positional relation of three CUB domains and five sushi domains in structure. The result of our molecular simulation suggested that the Aig1l protein was possibly related to cell adhesion and/or axon guidance of neurons.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013 2012 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (5 results) (of which Invited: 2 results) Book (1 results)

  • [Journal Article] 鍼灸研究の新展開:お灸のバイオインフォマティクス2015

    • Author(s)
      大田美香
    • Journal Title

      全日本鍼灸学会雑誌

      Volume: 65 Pages: 3-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photomechanical ablation of biological tissue induced by focused femtosecond laser and its application for acupuncture2013

    • Author(s)
      Yoichiroh Hosokawa, Mika Ohta, Akihiko Ito, and Yutaka Takaoka
    • Journal Title

      Appl. Phys. A

      Volume: Vol.110 No.3 Issue: 3 Pages: 613-616

    • DOI

      10.1007/s00339-012-7138-5

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] 東洋医学の治療効果研究へのバイオインフォマティクスの応用2014

    • Author(s)
      大田美香、三浦研爾、一瀬晃洋、菅野亜紀、高岡 裕
    • Organizer
      平成26年度日本東洋医学会関西支部例会
    • Place of Presentation
      スターゲイトホテル関西エアポート(大阪府泉佐野市)
    • Year and Date
      2014-10-26
    • Related Report
      2014 Annual Research Report
  • [Presentation] 熱刺激に対する細胞反応のバイオインフォマティクス解析2014

    • Author(s)
      大田美香、三浦研爾、前田英一、菅野亜紀、高岡 裕
    • Organizer
      第87回日本生化学会大会
    • Place of Presentation
      国立京都国際会館(京都市左京区)
    • Year and Date
      2014-10-15 – 2014-10-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 鍼灸研究の新展開:お灸のバイオインフォマティクス2014

    • Author(s)
      大田美香
    • Organizer
      第63回全日本鍼灸学会学術大会
    • Place of Presentation
      ひめぎんホール(愛媛県松山市)
    • Year and Date
      2014-05-16 – 2014-05-18
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] 鍼刺激で発見したマウスAig1l遺伝子とそのタンパク質の生化学/生物物理

    • Author(s)
      大田美香
    • Organizer
      第64回日本東洋医学会学術総会
    • Place of Presentation
      城山観光ホテル
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] 鍼通電刺激の基礎研究で発見したAig1lタンパク質の機能解析

    • Author(s)
      大田美香、三浦研爾、菅野亜紀、小田 剛、一瀬晃洋、前田英一、高岡 裕
    • Organizer
      平成24年度日本東洋医学会関西支部例会
    • Place of Presentation
      千里ライフサイエンスセンター
    • Related Report
      2012 Research-status Report
  • [Book] Acupuncture in Modern Medicine2012

    • Author(s)
      Lucy L. Chen
    • Total Pages
      389
    • Publisher
      InTech Publishers
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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