Study for anti-cancer effect of ultraviolet-C on colon cancer

• Project/Area Number: 24590939
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Gifu University
• Principal Investigator: ADACHI Seiji 岐阜大学, 医学(系)研究科(研究院), 非常勤講師 (50467205)
• Co-Investigator(Kenkyū-buntansha): YASUDA Ichiro 帝京大学, 医学部, 教授 (00377673)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 紫外線 / 大腸がん / 膵がん / ヒ素 / 細胞周期 / 細胞遊走能 / がん予防 / EGFR / 脂質ラフト / arsenite

Outline of Final Research Achievements

Because most colorectal cancers (CRC) evolve from colorectal adenomas, early detection and resection of colorectal adenoma enable us to evade the death from CRC. We have previously reported that ultraviolet-C (UV-C) induces CRC cell proliferation by desensitization of EGFR, which leads oncogenic signaling in these cells. In this study, we newly found that the combination of low dose cisplatin and low dose UV-C synergistically exerted anti-cancer effect by down-regulating RTK, such as EGFR and HER2. Moreover, we found that UVC inhibits PDGF-BB-induced migration by suppressing the Akt-GSK3β pathway in pancreatic cancer cells. In addition, we reported that arsenite inhibits PDGF-BB-induced migration by suppressing Akt pathway in pancreatic cancer cells. Hence, UV-C as well as arsenite could be a useful tool for the treatment of the patients with some types of pancreatic cancer without adverse effect on normal pancreatic cells.

Research Products

• [Journal Article] Cytokeratin-positive Fibroblastic Reticular Cell Tumor With Follicular Dendritic Cell Features: A Case Report and Review of the Literature. (2015)
  • Author(s): Goto N, Tsurumi H, Takami T, Futamura M, Morimitsu K, Takata K, Sato Y, Yoshino T, Adachi S, Saito K, Yamakawa M.
  • Journal Title: Am J Surg Pathol. Volume: 39 Issue: 4 Pages: 573-580
  • DOI: 10.1097/pas.0000000000000362
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Endoscopic papillary large balloon dilation as a salvage procedure for basket impaction during retrieval of common bile duct stones. (2014)
  • Author(s): Mabuchi M, Iwashita T, Yasuda I, Okuno M, Uemura S, Nakashima M, Doi S, Adachi S, Shimizu M, Mukai T, Tomita E, Moriwaki H.
  • Journal Title: Dig Dis Sci. Volume: 59 Issue: 1 Pages: 220-223
  • DOI: 10.1007/s10620-013-2845-0
  • Peer Reviewed / Open Access
• [Journal Article] Delayed stenosis of the small intestine after cardiopulmonary arrest. (2014)
  • Author(s): Adachi S, Okuno M, Horibe Y, Ono T, Goto N, Nakamura N, Iwama M, Yamauchi O, Saito K.
  • Journal Title: Nihon Shokakibyo Gakkai Zasshi Volume: 111 Pages: 2319-2325
  • NAID: 130004704565
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Comparison of long-term outcomes after endoscopic sphincterotomy versus endoscopic papillary balloon dilation: a propensity score-based cohort analysis. (2013)
  • Author(s): Doi S, Yasuda I, Mukai T, Iwashita T, Uemura S, Yamauchi T, Nakashima M, Adachi S, Shimizu M, Tomita E, Itoi T, Moriwaki H.
  • Journal Title: J Gastroenterol. Volume: 48 Issue: 9 Pages: 1090-1096
  • DOI: 10.1007/s00535-012-0707-8
  • NAID: 10031201980
  • Peer Reviewed
• [Journal Article] Percutaneous transgallbladder rendezvous for enteroscopic management of choledocholithiasis in patients with surgically altered anatomy. (2013)
  • Author(s): Okuno M, Iwashita T, Yasuda I, Mabuchi M, Uemura S, Nakashima M, Doi S, Adachi S, Mukai T, Moriwaki H.
  • Journal Title: Scand J Gastroenterol. Volume: 48 Issue: 8 Pages: 974-978
  • DOI: 10.3109/00365521.2013.805812
  • Peer Reviewed
• [Journal Article] A case of advanced gastric cancer with liver abscesses. (2013)
  • Author(s): Okuno M, Adachi S, Nakamura N, Yamauchi O, Saito K, Hirose Y, Ibuka T, Yasuda I, Moriwaki H
  • Journal Title: Nihon Shokakibyo Gakkai Zasshi. Volume: 110 Pages: 869-874
  • NAID: 10031169253
  • Peer Reviewed
• [Journal Article] UVC irradiation suppresses platelet-derived growth factor-BB-induced migration in human pancreatic cancer cells. (2012)
  • Author(s): Kawaguchi J, Adachi S, Yasuda I, Yamauchi T, Yoshioka T, Itani M, Kozawa O and Moriwaki H.
  • Journal Title: Oncol. Rep. Volume: 27巻 Issue: 4 Pages: 935-939
  • DOI: 10.3892/or.2011.1612
  • Peer Reviewed
• [Journal Article] Cisplatin and ultra-violet-C synergistically down-regulate receptor tyrosine kinases in human colorectal cancer cells. (2012)
  • Author(s): Kawaguchi J, Adachi S, Yasuda I, Yamauchi T, Nakashima M, Ohno T, Shimizu M, Yoshioka T, Itani M, Kozawa O and Moriwaki H.
  • Journal Title: Mol. Cancer. Volume: 11巻 Issue: 1 Pages: 45-45
  • DOI: 10.1186/1476-4598-11-45
  • Peer Reviewed
• [Journal Article] Endoscopic ultrasound-guided fine needle aspiration biopsy for diagnosis of lymphoproliferative disorders: Feasibility of immunohistological, flow cytometric, and cytogenetic assessments. (2012)
  • Author(s): Yasuda I, Goto N, Tsurumi H, Nakashima M, Doi S, Iwashita T, Kanemura N, Kasahara S, Adachi S, Hara T, Shimizu M, Takami T, Moriwaki H.
  • Journal Title: Am J Gastroenterol Volume: 107 Issue: 3 Pages: 397-404
  • DOI: 10.1038/ajg.2011.350
  • Peer Reviewed
• [Journal Article] Use of samples from endoscopic ultrasound-guided 19-gauge fine-needle aspiration in diagnosis of autoimmune pancreatitis. (2012)
  • Author(s): Iwashita T, Yasuda I, Doi S, Ando N, Nakashima M, Adachi S, Hirose Y, Mukai T, Iwata K, Tomita E, Itoi T, Moriwaki H.
  • Journal Title: Clin Gastroenterol Hepatol Volume: 10 Issue: 3 Pages: 316-322
  • DOI: 10.1016/j.cgh.2011.09.032
  • Peer Reviewed
• [Journal Article] Infected mediastinal cyst following endoscopic ultrasonography-guided fine-needle aspiration with rupture into the esophagus. (2012)
  • Author(s): Iwashita T, Yasuda I, Uemura S, Moriwaki H.
  • Journal Title: Dig Endosc Volume: 24 Issue: 5 Pages: 386-386
  • DOI: 10.1111/j.1443-1661.2012.01287.x
  • Peer Reviewed
• [Presentation] 当院でのEUSの現状＆膵癌治療における紫外線療法の可能性 (2014)
  • Author(s): 足立政治
  • Organizer: 第2回美濃消化器懇話会
  • Place of Presentation: 岐阜
  • Year and Date: 2014-08-08
• [Presentation] 膵がん治療における紫外線療法の有用性について (2014)
  • Author(s): 足立政治、安田一朗、河口順二、山内貴裕、中島賢憲、齋藤公志郎、森脇久隆
  • Organizer: 第45回 日本膵臓学会総会
  • Place of Presentation: 北九州
  • Year and Date: 2014-07-11
• [Presentation] 大腸がん細胞に対する短波長紫外線(UV-C)と低用量cisplatinの併用効果 (2012)
  • Author(s): 河口順二、足立政治、安田一朗、山内貴裕、中島憲賢、小澤 修、森脇久隆
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] 膵がん細胞に対する短波長紫外線(UV-C)とジェムシタビン併用による腫瘍増殖抑制およびアポトーシス誘導効果 (2012)
  • Author(s): 山内貴裕、足立政治、安田一朗、河口順二、中島賢憲、小澤 修、森脇久隆
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] 短波長紫外線(UV-C)照射による大腸がん制御機構について (2012)
  • Author(s): 足立政治、安田一朗、中島賢憲、山内貴裕、河口順二、小澤 修、森脇久隆
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] Cisplatin and ultra-violet-C synergistically down-regulate receptor tyrosine kinases in human colon cancer cells (2012)
  • Author(s): Kawaguchi J, Adachi S, Yasuda I, Yamauchi T, Nakashima M, Ohno T, Shimizu M, Moriwaki H
  • Organizer: DDW2012
  • Place of Presentation: サンディエゴ(USA)
• [Presentation] 膵がん治療におけるgemcitabineと紫外線(UV-C)の併用効果について (2012)
  • Author(s): 足立政治, 安田一朗, 河口順二, 山内貴裕, 中島賢憲, 齋藤公志郎, 森脇久隆
  • Organizer: 第54回日本消化器病学会大会
  • Place of Presentation: 神戸