| Project/Area Number |
24590939
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Gifu University |
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Principal Investigator |
ADACHI Seiji 岐阜大学, 医学(系)研究科(研究院), 非常勤講師 (50467205)
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA Ichiro 帝京大学, 医学部, 教授 (00377673)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 紫外線 / 大腸がん / 膵がん / ヒ素 / 細胞周期 / 細胞遊走能 / がん予防 / EGFR / 脂質ラフト / arsenite |
|---|
| Outline of Final Research Achievements |
Because most colorectal cancers (CRC) evolve from colorectal adenomas, early detection and resection of colorectal adenoma enable us to evade the death from CRC. We have previously reported that ultraviolet-C (UV-C) induces CRC cell proliferation by desensitization of EGFR, which leads oncogenic signaling in these cells. In this study, we newly found that the combination of low dose cisplatin and low dose UV-C synergistically exerted anti-cancer effect by down-regulating RTK, such as EGFR and HER2. Moreover, we found that UVC inhibits PDGF-BB-induced migration by suppressing the Akt-GSK3β pathway in pancreatic cancer cells. In addition, we reported that arsenite inhibits PDGF-BB-induced migration by suppressing Akt pathway in pancreatic cancer cells. Hence, UV-C as well as arsenite could be a useful tool for the treatment of the patients with some types of pancreatic cancer without adverse effect on normal pancreatic cells.
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