Molecular analysis of liver diseases according to aging

• Project/Area Number: 24590968
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Mie University
• Principal Investigator: SHIRAKI Katsuya 三重大学, 医学(系)研究科(研究院), 准教授 (90263003)
• Co-Investigator(Kenkyū-buntansha): SUGIMOTO Kazushi 三重大学, 医学部附属病院, 講師 (60378370) ; UCHIDA Kazuhiko 筑波大学, 医学医療系, 准教授 (90211078)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 加齢 / 発癌 / 遺伝子 / SIRT / 老化 / SIRT1 / ヒストン

Outline of Final Research Achievements

Aging is mostly related with gene expression profile in liver. These gene expression patterns are closely associated with liver pathogenesis. We found lots of genes that are critical in aging and carcinogenesis, which might be gene targets in future for the regulation of diseases.