| Project/Area Number |
24590977
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Okayama University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TSUTSUMI Koichiro 岡山大学, 岡山大学病院, 助教 (40610910)
SHIRAHA Hidenori 岡山大学, 岡山大学病院, 講師 (40379748)
YAMAMOTO Kazuhide 岡山大学, 大学院医歯薬学総合研究科, 教授 (90140491)
NASU Yasutomo 岡山大学, 岡山大学病院, 教授 (20237572)
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| Research Collaborator |
UCHIDA Daisuke 岡山大学, 岡山大学病院, 医員 (50749215)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | REIC/Dkk-3 / 膵臓癌 / 遺伝子治療 / 癌抑制遺伝子 / REIC遺伝子 / 消化器癌 / 膵癌 / 癌遺伝子治療 |
|---|
| Outline of Final Research Achievements |
REIC/Dkk-3, tumor suppressor gene, is down-regulated in various malignant tumors. In the current study, we assessed the effects of REIC/Dkk-3 gene therapy in pancreatic cancer. The REIC/Dkk-3 expression was lost in the pancreatic cancer cells, and tissues. Overexpression of REIC/Dkk-3 induced the apoptosis of the pancreatic cancer cells and inhibited tumor growth in xenograft mice model. REIC/Dkk-3 gene therapy is an attractive therapeutic tool for the pancreatic cancer.
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