Role of B cell activating factor in the pathogenesis of NAFLD

• Project/Area Number: 24590979
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: Ehime University
• Principal Investigator: ABE MASANORI 愛媛大学, 医学(系)研究科(研究院), 准教授 (40432786)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: アディポカイン / 脂肪肝 / インスリン抵抗性 / 肥満 / メタボリック症候群

Outline of Final Research Achievements

In this study, we analyzed the role of B cell activating factor (BAFF), which is one of the adipokines, in the pathogenesis of fatty liver diseases, especially in visceral adipose tissue and liver. We found that oxidative stress induced BAFF expression in adipocytes, and BAFF led to impaired insulin sensitivity in visceral adipose tissue. On the other hand, BAFF had a protective role in hepatic steatosis by regulating lipid metabolism in the liver. These data indicate that the role of BAFF in the liver may differ from that in visceral adipose tissue in the pathogenesis of fatty liver diseases.

Research Products

• [Journal Article] Diminished immune response to vaccinations in a murine model of obesity: Role of myeloid-derived suppressor cells. (2015)
  • Author(s): Chen S, Akbar SMF, Miyake T, Abe M, Al-Mahtab M, Furukawa S, Matsuura B, Hiasa Y, Onji M.
  • Journal Title: Obes Res Clin Pract Volume: 9 Issue: 1 Pages: 35-44
  • DOI: 10.1016/j.orcp.2013.12.006
  • Peer Reviewed / Open Access
• [Journal Article] Nonalcoholic fatty liver disease: portal hypertension due to outflow block in patients without cirrhosis. (2015)
  • Author(s): Hirooka M, Koizumi Y, Miyake T, Ochi H, Tokumoto Y, Tada F, Matsuura B, Abe M, Hiasa Y.
  • Journal Title: Radiology Volume: 274 Issue: 2 Pages: 597-604
  • DOI: 10.1148/radiol.14132952
  • Peer Reviewed
• [Journal Article] Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study. (2014)
  • Author(s): Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Abe M, Kitai K, Matsuura B, Hiasa Y.
  • Journal Title: PLoS ONE Volume: 9 Issue: 9 Pages: e107882-e107882
  • DOI: 10.1371/journal.pone.0107882
  • Peer Reviewed / Open Access
• [Journal Article] B cell activating factor in obesity is regulated by oxidative stress in adipocytes (2013)
  • Author(s): Tada F, Abe M, Kawasaki K, Miyake T, Chen S, Hiasa Y, Matsuura B, Onji M
  • Journal Title: Journal of Clinical Biochemistry and Nutrition Volume: 52 Pages: 120-127
  • NAID: 130004466705
  • Peer Reviewed
• [Journal Article] B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease. (2013)
  • Author(s): Miyake T, Abe M, Tokumoto Y, Hirooka M, Furukawa S, Kumagi T, Hamada M, Kawasaki K, Tada F, Ueda T, Hiasa Y, Matsuura B, Onji M.
  • Journal Title: Hepatol Int Volume: 7 Issue: 2 Pages: 539-547
  • DOI: 10.1007/s12072-012-9345-8
  • Peer Reviewed
• [Journal Article] Blockade of B-cell-activating factor signaling enhances hepatic steatosis induced by a high-fat diet and improves insulin sensitivity. (2013)
  • Author(s): Kasawaki K, Abe M, Tada F, Tokumoto Y, Chen S, Miyake T, Furukawa S, Matsuura B, Hiasa Y, Onji M.
  • Journal Title: Laboratory Investigation Volume: 93 Issue: 3 Pages: 311-321
  • DOI: 10.1038/labinvest.2012.176
  • Peer Reviewed
• [Journal Article] 内臓脂肪組織におけるＢ細胞活性化因子（BAFF）の役割 (2012)
  • Author(s): 阿部雅則、濱田麻穂、恩地森一
  • Journal Title: 消化器内科 Volume: 54 Pages: 645-649
• [Presentation] 非アルコール性脂肪性肝疾患におけるWFA+-M2BPの線維化マーカーとしての有用性 (2014)
  • Author(s): 阿部雅則、三宅映己、今井康陽、日野啓輔、髭修平、坂元亨宇、山田剛太郎、鹿毛政義、是永匡紹、溝上雅史、久野敦、成松久
  • Organizer: 第62回日本臨床検査医学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2014-11-23 – 2014-11-25
• [Presentation] NAFLDの病態におけるB細胞活性化因子（BAFF）の糖代謝への影響 (2014)
  • Author(s): 川崎敬太郎、阿部雅則、多田藤政、三宅映己、徳本良雄、松浦文三、日浅陽一
  • Organizer: 第１回肝臓と糖尿病・代謝研究会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-04
• [Presentation] 非アルコール性脂肪性肝疾患（NAFLD）の病態における骨髄由来抑制細胞の関与 (2014)
  • Author(s): 阿部雅則、三宅映己、多田藤政、徳本良雄、川崎敬太郎、越智裕紀、小泉洋平、廣岡昌史、松浦文三、日浅陽一
  • Organizer: 第50回日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2014-05-29 – 2014-05-30
• [Presentation] インスリン抵抗性および肝脂肪化におけるB細胞活性化因子(BAFF)の肝脂肪化に対する役割 (2013)
  • Author(s): 川崎敬太郎、阿部雅則、三宅映己、多田藤政、徳本良雄、松浦文三、恩地森一
  • Organizer: 第56回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本
• [Presentation] B cell activating factor (BAFF) is associates with the histologically severity of non-alcoholic fatty liver diseases. (2012)
  • Author(s): Abe M, Miyake T, Tokumto Y, Kawasaki K, Tada F, Hamada M, Furukawa S, Hiasa Y, Matsuura B, Onji M.
  • Organizer: The 3rd Asian-Pacific Topic Conference
  • Place of Presentation: 東京