Role of B cell activating factor in the pathogenesis of NAFLD
Project/Area Number |
24590979
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Gastroenterology
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Research Institution | Ehime University |
Principal Investigator |
ABE MASANORI 愛媛大学, 医学(系)研究科(研究院), 准教授 (40432786)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | アディポカイン / 脂肪肝 / インスリン抵抗性 / 肥満 / メタボリック症候群 |
Outline of Final Research Achievements |
In this study, we analyzed the role of B cell activating factor (BAFF), which is one of the adipokines, in the pathogenesis of fatty liver diseases, especially in visceral adipose tissue and liver. We found that oxidative stress induced BAFF expression in adipocytes, and BAFF led to impaired insulin sensitivity in visceral adipose tissue. On the other hand, BAFF had a protective role in hepatic steatosis by regulating lipid metabolism in the liver. These data indicate that the role of BAFF in the liver may differ from that in visceral adipose tissue in the pathogenesis of fatty liver diseases.
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Report
(4 results)
Research Products
(12 results)
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[Journal Article] Hyperuricemia is a risk factor for the onset of impaired fasting glucose in men with a high plasma glucose level: a community-based study.2014
Author(s)
Miyake T, Kumagi T, Furukawa S, Hirooka M, Kawasaki K, Koizumi M, Todo Y, Yamamoto S, Abe M, Kitai K, Matsuura B, Hiasa Y.
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Journal Title
PLoS ONE
Volume: 9
Issue: 9
Pages: e107882-e107882
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] B cell-activating factor is associated with the histological severity of nonalcoholic fatty liver disease.2013
Author(s)
Miyake T, Abe M, Tokumoto Y, Hirooka M, Furukawa S, Kumagi T, Hamada M, Kawasaki K, Tada F, Ueda T, Hiasa Y, Matsuura B, Onji M.
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Journal Title
Hepatol Int
Volume: 7
Issue: 2
Pages: 539-547
DOI
Related Report
Peer Reviewed
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