| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
The mechanism of the onset of acute pancreatitis is still unknown. There has been no progress in the treatment of acute pancreatitis. The pancreas of interferon regulatory factor-2 (IRF-2) knock-out mice shows the early phase of acute pancreatitis (Mashima H et al. Gastroenterology 2011). We have selected candidate genes of acute pancreatitis among the highly up-regulated or down-regulated genes in IRF2 KO pancreas compared to the control. Finally, we have chosen the two genes, which are both calcium-binding proteins. Then, we analyzed the function of S100g and Anxa10 by using a cell line, which is manipulated genetically, and wild-type and knock-out mice. We have shown S100g may have an important role in the onset of acute pancreatitis.
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