Application of genome informatics for the molecular targeting therapy against cholangiocarcinoma

• Project/Area Number: 24591006
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Gastroenterology
• Research Institution: The University of Tokyo
• Principal Investigator: KOGURE Hirofumi 東京大学, 医学部附属病院, 助教 (60568921)
• Co-Investigator(Kenkyū-buntansha): TATEISHI Keisuke 東京大学, 医学部附属病院, 講師 (20396948)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 胆道癌 / ヒストン修飾 / 胆道がん / エピジェネテイクス / 胆管がん

Outline of Final Research Achievements

Recent reports have documented gene mutations found in cholangiocellular carcinoma by comprehensive genomic analysis, however it remains unknown whether or how the mutations contribute to malignant features of cholangiocarcinoma. The status of epigenome as well as genome is suspected as the significant factor for tumor characteristics. In this research, we address the role of alteration of genome and epigenome in cholangiocarcinoma.

Research Products

• [Journal Article] Short- and long-term outcomes ofendoscopic papillary large balloon dilation with or without sphincterotomy for removal of large bile duct stones. (2014)
  • Author(s): Kogure H, Tsujino T, Isayama H, Takahara N, Uchino R, Hamada T, MiyabayashiK, Mizuno S, Mohri D, Yashima Y, Kawakubo K, Sasaki T, Yamamoto N, Nakai Y,Hirano K, Sasahira N, Tada M, Koike K.
  • Journal Title: Scand J Gastroenterol. Volume: ４９ Issue: 1 Pages: 121-128
  • DOI: 10.3109/00365521.2013.848470
  • Peer Reviewed
• [Journal Article] Histone demethylase KDM4C regulates sphere formation by mediating the cross talk between Wnt and Notch pathways in colonic cancer cells. (2013)
  • Author(s): Yamamoto S, Tateishi K, Kudo Y, Yamamoto K, Isagawa T, Nagae G, Nakatsuka T, Asaoka Y, Ijichi H, Hirata Y, Otsuka M, Ikenoue T, Aburatani H, Omata M, Koike K.
  • Journal Title: Carcinogenesis Volume: 10 Issue: 10 Pages: 2380-8
  • DOI: 10.1093/carcin/bgt174
  • Peer Reviewed
• [Journal Article] Erlotinib prolongs survival in pancreatic cancer by blocking gemcitabine-induced MAPK signals. (2013)
  • Author(s): Miyabayashi K, Ijichi H, Mohri D, Tada M, Yamamoto K, Asaoka Y, Ikenoue T, Tateishi K, Nakai Y, Isayama H, Morishita Y, Omata M, Moses HL, Koike K.
  • Journal Title: Cancer Res Volume: 73 Issue: 7 Pages: 2221-34
  • DOI: 10.1158/0008-5472.can-12-1453
  • Peer Reviewed
• [Journal Article] Lower incidence of biliary carcinoma in patients with primary sclerosing cholangitis and high serum levels of immunoglobulin E. (2012)
  • Author(s): Hirano K, Tada M, Kogure H,, Koike K.,et.al.
  • Journal Title: Clin Gastroenterol Hepatol Volume: 10 Pages: 79-83
  • Peer Reviewed
• [Presentation] JHDM3C regulates sphere formation by mediating the crosstalk between Wnt and Notch pathways
  • Author(s): Shinzo Yamamoto, Keisuke Tateishi, Yotaro Kudo, Keisuke Yamamoto, Takayuki Isagawa, Genta Nagae, Takuma Nakatsuka, Yoshinari Asaoka, Hideaki Ijichi, Masao Omata, Hiroyuki Aburatani, and Kazuhiko Koike
  • Organizer: 第72回日本癌学会学術総会
  • Place of Presentation: 横浜
• [Book] 内科学「良性胆道腫瘍」 (2012)
  • Author(s): 立石敬介
  • Publisher: 西村書店