| Project/Area Number |
24591025
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NISHIKURA Ken 新潟大学, 医歯学系, 准教授 (30272818)
WATANABE Gen 新潟大学, 医歯学系, 助教 (20345523)
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| Research Collaborator |
TAKEUCHI Manabu
HASHIMOTO Satoru
MIZUNO Ken-ichi
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥130,000 (Direct Cost: ¥100,000、Indirect Cost: ¥30,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 早期胃がん / 画像強調内視鏡 / ピロリ除菌 / 胃腺腫 / 粘液形質 |
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| Outline of Final Research Achievements |
We confirmed that 44 % of the early gastric cancers that were detected after successful H. pylori eradication showed a gastritis-like appearance under narrow-band imaging with magnified endosocpy (NBI-ME), resembling adjacent noncancerous mucosa. In endoscopic surveillance of early gastric cancer, NBI-ME diagnosis of a gastritis-like appearance should be considered more carefully for patients that have undergone successful eradication, compared to patients without eradication therapy.
We also confirmed the efficacy of NBI-ME for detection of gastric phenotypes according to the proposed A-B classification system. NBI-ME has the advantage of visualizing the papillary (A type) or groove (AB type) microstructure, which are features of carcinomas with gastric or gastrointestinal phenotypes. Even if a gastric lesion is small and diagnosed as adenoma or borderline by forceps biopsy, we recommend clinical treatment to A type and AB type lesions.
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