| Project/Area Number |
24591027
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATO Junji 札幌医科大学, 医学部, 教授 (20244345)
ISHIWATARI Hirotoshi 札幌医科大学, 医学部, 助教 (90468083)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | IPMN / 膵癌 / バイオマーカー / EUS-FNA / プロテオーム |
|---|
| Outline of Final Research Achievements |
Intraductal papillary mucinous neoplasm (IPMN) has been shown to develop pancreatic cancer. However, there is no available biomarker to predict incidence of malignant transformation in IPMN. We carried out proteome analysis using cystic fluid obtained by EUS-FNA to identify predictive biomarker. We found two candidates which significantly highly expressed in IPMN as well as advanced pancreatic cancer. We are planning to conduct clinical study to verify usefulness of predicating malignant transformation in IPMN as a biomarker.
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