The impact of macrophage transcription factor MafB on rupture of abdominal aortic aneurysm
Project/Area Number |
24591033
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
|
Research Institution | Yamagata University |
Principal Investigator |
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
|
Keywords | 腹部大動脈瘤 / マクロファージ / MafB / 転写因子MafB / ニコチン / 喫煙 / PET/CT |
Outline of Final Research Achievements |
Transcription factor MafB is expressed only in monocytes and macrophages among hematopoietic cells, which plays a role in the terminal differentiation of macrophages. MafB knockout mice die immediately after birth due to developmental anomalies of neurons in the respiratory centre. We generated transgenic mice that express dominant negative (DN) MafB capable of suppressing endogenous MafB transcription activity only in macrophages. The abdominal aortic aneurysm (AAA) model was developed by 1000 ng/kg/min of angiotensin II infusion in apolipoprotein E-deficient (ApoE KO) mice and ApoE KO/DN MafB mice. There was no difference in development of AAA between ApoE KO mice and ApoE KO/DN MafB mice. We investigate impact of MafB on rupture of AAA.
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Report
(4 results)
Research Products
(11 results)
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[Journal Article] A novel mouse model of aortic valve stenosis induced by direct wire injury.2014
Author(s)
Honda S, Miyamoto T, Watanabe T, Narumi T, Kadowaki S, Honda Y, Otaki Y, Hasegawa H, Netsu S, Funayama A, Ishino M, Nishiyama S, Takahashi H, Arimoto T, Shishido T, Miyashita T, Kubota I.
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Journal Title
Arterioscler Thromb Vasc Biol.
Volume: 34
Issue: 2
Pages: 270-278
DOI
Related Report
Peer Reviewed
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[Journal Article] Midkine exacerbates pressure overload-induced cardiac remodeling.2014
Author(s)
Netsu S, Shishido T, Kitahara T, Honda Y, Funayama A, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Arimoto T, Nishiyama S, Watanabe T, Woo CH, Takeishi Y, Kubota I.
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Journal Title
Biochem Biophys Res Commun.
Volume: 443
Issue: 1
Pages: 205-210
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Atrial endothelial impairment through Toll-like receptor 4 signaling causes atrial thrombogenesis.2014
Author(s)
Katoh S, Honda S, Watanabe T, Suzuki S, Ishino M, Kitahara T, Funayama A, Netsu S, Sasaki T, Shishido T, Miyamoto T, Sadahiro M, Kubota I.
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Journal Title
Heart Vessels.
Volume: 29
Issue: 2
Pages: 263-272
DOI
Related Report
Peer Reviewed
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[Journal Article] Diacylglycerol kinase α exacerbates cardiac injury after ischemia/reperfusion.2014
Author(s)
Sasaki T, Shishido T, Kadowaki S, Kitahara T, Suzuki S, Katoh S, Funayama A, Netsu S, Watanabe T, Goto K, Takeishi Y, Kubota I.
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Journal Title
Heart Vessels.
Volume: 29
Issue: 1
Pages: 110-118
DOI
Related Report
Peer Reviewed
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[Journal Article] Cardiac nuclear High Mobility Group Box 1 prevents the development of cardiac hypertrophy and heart failure.2013
Author(s)
Funayama A, Shishido T, Netsu S, Narumi T, Kadowaki S, Takahashi H, Miyamoto T, Watanabe T, Woo CH, Abe JI, Kuwahara K, Nakao K, Takeishi Y, Kubota I.
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Journal Title
Cardiovasc Res.
Volume: 99
Issue: 4
Pages: 657-64
DOI
Related Report
Peer Reviewed
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[Presentation] Plasma thioredoxin-1 level is associated with renal tubular damage and predicts poor prognosis in patients with chronic heart failure.2013
Author(s)
8) Otaki Y, Watanabe T, Takahashi H, Tamura H, Nishiyama S, Arimoto T, Miyashita T, Shishido T, Miyamoto T, Kubota I
Organizer
ESC CONGRESS
Place of Presentation
Amsterdam RAI convention center (Amsterdam, Netherlands)
Related Report
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[Presentation] The role of macrophage transcriptional factor MafB in atherosclerotic plaque stability.2013
Author(s)
11) Hasegawa H, Kato S, Watanabe T, Takahashi H, Arimoto T, Shishido T, Miyashita T, Miyamoto T, Shibata Y, Kubota I
Organizer
ESC CONGRESS
Place of Presentation
Amsterdam RAI convention center (Amsterdam, Netherlands)
Related Report
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[Presentation] Cardiac-specific overexpression of high-mobility group box 1 attenuates cardiomyocyte apoptosis and mitochondrial dysfunction during the pathogenesis of doxorubicin cardiomyopathy.2013
Author(s)
16) Narumi T, Shishido T, Funayama A, Yokoyama M, Kinoshita D, Kadowaki S, Honda Y, Otaki Y, Nishiyama S, Takahashi H, Arimoto T, Miyashita T, Miyamoto T, Watanabe T, Kubota I
Organizer
American Heart Association Scientific Sessions
Place of Presentation
Dallas convention center (Dallas, TX, USA)
Related Report
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[Presentation] Ubiquitin E3 ligase ITCH ameliorates reactive oxygen species-induced cardiotoxicity through interaction with thioredoxin-interacting protein.2013
Author(s)
19) Otaki Y, Takahashi H, Watanabe T, Narumi T, Kadowaki S, Honda Y, Arimoto T, Shishido T, Miyashita T, Miyamoto T, Kubota I
Organizer
American Heart Association Scientific Sessions
Place of Presentation
Dallas convention center (Dallas, TX, USA)
Related Report
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