Therapeutic approach for diastolic heart failure through regenerative medicine
Project/Area Number |
24591047
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Circulatory organs internal medicine
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Research Institution | Nagoya University |
Principal Investigator |
Shintani Satoshi 名古屋大学, 医学(系)研究科(研究院), 寄附講座・准教授 (20309777)
|
Co-Investigator(Kenkyū-buntansha) |
Murohara TOYOAKI 名古屋大学, 大学院医学系研究科, 教授 (90299503)
|
Project Period (FY) |
2012-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 脂肪由来間葉系幹細胞 / 血管新生 / 抗炎症作用 / M2マクロファージ / 貴下脂肪細胞由来間葉系前駆細胞 / 内皮前駆細胞 / 再生医療 / 細胞移植 / 拡張不全心 / 国際情報交換 / 脂肪組織由来間葉系前駆細胞 / プロスタグランジンE2 / 拡張不全型心不全 / 国際情報交換(米国) |
Outline of Final Research Achievements |
Transplantation of adipose-derived regenerative cell (ADRC) enhances ischemia-induced angiogenesis, but the underlying mechanism remains unknown. Here, we compared the efficacy between ADRC and bone marrow mononuclear cell (BM-MNC) on cell migration, apoptosis and anti-inflammation. ADRC had as great angiogenic and anti-apoptotic effect as BM-MNC. However, anti-inflammation effect was stronger in ADRC than that in BM-MNC. In mice studies, we presented that ADRCs polarized into the IL-10-releasing M2 macrophages through PGE2-EP2/4 axis and suppressed the expressions of TNF-α and IL-6 in the ischemic muscle. Gene expressions of several angiogenic cytokines were amplified in the macrophages cultured in ADRC-CM rather than BM-MNC-CM.
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Report
(5 results)
Research Products
(23 results)
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[Journal Article] Cardiovascular events increased at normal and high-normal blood pressure in young and middle-aged Japanese male smokers but not in nonsmokers.2013
Author(s)
Kondo T, Osugi S, Shimokata K, Honjo H, Okumura N, Matsudaira K, Yamashita K, Maeda K, Muramatsu T, Shintani S, Matsushita K, Murohara T.
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Journal Title
J Hypertens.
Volume: 31
Issue: 9
Pages: 263-270
DOI
Related Report
Peer Reviewed
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[Journal Article] Effect of current smoking and blood pressure on cardiovascular events and mortality for workers: number of events for multivariante analysis to keep validity. Reply.2013
Author(s)
Kondo T, Osugi S, Shimokata K, Honjo H, Okumura N, Matsudaira K, Yamashita K, Maeda K, Muramatsu T, Shintani S, Matsushita K, Murohara T.
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Journal Title
J Hypertens.
Volume: 31
Issue: 2
Pages: 1920-1921
DOI
Related Report
Peer Reviewed
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[Journal Article] The significance of measuring body fat percentage determined by bioelectrical impedance analysis for detecting subjects with cardiovascular disease risk factors2012
Author(s)
Yamashita K, Kondo T, Osugi S, Shimokata K, Maeda K, Okumura N, Matsudaira K, Shintani S, Muramatsu T, Matsushita K, Murohara T.
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Journal Title
Cir J.
Volume: 76
Pages: 2435-2442
NAID
Related Report
Peer Reviewed
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