Analysis of pathophysiologic and genetic mechanisms and establishment of treatment therapy in J wave syndrome

• Project/Area Number: 24591052
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Okayama University
• Principal Investigator: NAGASE Satoshi 岡山大学, 医歯(薬)学総合研究科, 助教 (50397907)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Kazufumi 岡山大学, 医歯薬学総合研究科, 准教授 (10335630) ; MORITA Hiroshi 岡山大学, 医歯薬学総合研究科, 教授 (50322227) ; NISHII Nobuhiro 岡山大学, 医歯薬学総合研究科, 講師 (50537214) ; KUSANO Kengo 独立行政法人国立循環器病研究センター, 心臓血管内科, 部長 (60314689)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: J波症候群 / Brugada症候群 / 遺伝子解析 / 心臓電気生理検査 / 心臓突然死

Outline of Final Research Achievements

We performed epicardial electrogram recording in left ventricle (LV) in 60 patients with J wave syndrome and 10 control subjects. Epicardial recording in LV revealed that prominent J wave or ST-segment elevation was more prevalent in symptomatic patients than that in asymptomatic patients. Prominent J wave in LV epicardium was coincided with the J wave in surface electrocardiogram. Prominent epicardial J wave was attenuated with constant atrial pacing and exaggerated with administration of pilsicainide. Epicardial electrogram recording in LV might be useful for prediction of fatal arrhythmic event in patients with J wave syndrome.

Research Products

• [Journal Article] Left ventricular epicardial electrogram recordings in idiopathic ventricular fibrillation with inferior and lateral early repolarization (2014)
  • Author(s): Nakagawa K, Nagase S, Morita H, Ito H
  • Journal Title: Heart Rhythm Volume: 11 Issue: 2 Pages: 314-317
  • DOI: 10.1016/j.hrthm.2013.10.057
  • Peer Reviewed
• [Journal Article] Association of early repolarization with long-term mortality and major adverse cardiac events in patients with ST-segment elevation myocardial infarction. (2014)
  • Author(s): Nagase S.
  • Journal Title: J Cardiol. Volume: in press. Issue: 3 Pages: 162-163
  • DOI: 10.1016/j.jjcc.2014.02.007
  • Peer Reviewed
• [Journal Article] Depolarization and Repolarization Abnormalities are Synergistically Associated with Fatal Arrhythmic Events in Patients with Brugada Syndrome. (2014)
  • Author(s): Tokioka K, Kusano KF, Morita H, Miura D, Nishii N, Nagase S, Nakamura K, Kohno K, Ito H, Ohe T.
  • Journal Title: J Am CollCardiol Volume: in press Issue: 20 Pages: 2131-2138
  • DOI: 10.1016/j.jacc.2014.01.072
  • Peer Reviewed
• [Presentation] Brugada症候群と早期再分極症候群に関する検討 (2014)
  • Author(s): 永瀬 聡
  • Organizer: Nagoya Arrhythmia Expert Conference
  • Place of Presentation: 名古屋
  • Year and Date: 2014-11-19
  • Invited
• [Presentation] 特発性心室細動の最近の話題 (2014)
  • Author(s): 永瀬 聡
  • Organizer: 第五回姫路心血管ネットワークセミナー
  • Place of Presentation: 姫路
  • Year and Date: 2014-11-07
  • Invited
• [Presentation] 非虚血性心疾患におけるＪ波の機序 (2014)
  • Author(s): 永瀬 聡
  • Organizer: 第29回 犬山不整脈カンファランス
  • Place of Presentation: 名古屋
  • Year and Date: 2014-08-23
  • Invited
• [Presentation] J wave syndromeの成因に関する検討 (2013)
  • Author(s): 永瀬 聡
  • Organizer: 阪神アブレーション研究会
  • Place of Presentation: 大阪、日本
  • Invited
• [Presentation] Prominent J wave or ST-segment Elevation in Left Ventricular Epicardium in Patients with Brugada Syndrome
  • Author(s): Satoshi Nagase
  • Organizer: Heartrhythm 2012
  • Place of Presentation: ボストン、マサチューセッツ州、アメリカ合衆国
• [Presentation] Left ventricular epicardial recordings in patients with J wave syndrome- Substrate of arrhythmogenic early repolarization
  • Author(s): Satoshi Nagase
  • Organizer: Asia Pacific Heart Rhythm Society
  • Place of Presentation: 台北、台湾
• [Presentation] J波症候群における左室心外膜側電位の検討
  • Author(s): 永瀬 聡
  • Organizer: 第29回 日本心電学会学術集会
  • Place of Presentation: 千葉
• [Presentation] Difference of Left Ventricular Epicardial Electrogram With and Without a History of Ventricular Fibrillation in Patients With Infero-lateral Early Repolarization
  • Author(s): 永瀬 聡
  • Organizer: 第77回 日本循環器学会学術集会
  • Place of Presentation: 横浜