The evaluation of CD44 in pathogenesis of abdominal aortic aneurysm and the development of new therapy

• Project/Area Number: 24591053
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Okayama University
• Principal Investigator: MIYOSHI Toru 岡山大学, 大学病院, 講師 (70444651)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Kazufumi 岡山大学, 医歯薬学総合研究科, 准教授 (10335630) ; YONEZAWA Tomoko 岡山大学, 医歯薬学総合研究科, 助教 (30304299) ; YOSHIDA Masashi 岡山大学, 医歯薬学総合研究科, 助教 (70532761)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 腹部大動脈瘤 / CD44 / 炎症性遺伝子 / 動脈硬化 / サイトカイン / ヒアルロン酸

Outline of Final Research Achievements

Immunohistochemical analysis of human abdominal aortic aneurysm revealed that the increased expression of CD44 and the degradation of hyaluronic acid were possibly involved in pathogenesis of abdominal aortic aneurysm. Experimental abdominal aortic aneurysm using CaCl2-induced model, the incidence of abdominal aortic aneurysm was significantly less in CD44 knockout mice compared to wild type mice. Liposome targeting CD44 was developed and the utility of its liposome is being studied.

Research Products

• [Journal Article] Pioglitazone prevents the endothelial dysfunction induced by ischemia and reperfusion in healthy subjects (2014)
  • Author(s): Sakatani Y, Miyoshi T, Oe H, Noda Y, Ohno Y, Nakamura K, Saito Y, Osawa K, Morita H, Kohno K, Ito H
  • Journal Title: Journal of cardiovascular pharmacology Volume: 64 Issue: 4 Pages: 326-331
  • DOI: 10.1097/fjc.0000000000000124
  • Peer Reviewed
• [Journal Article] Left ventricular epicardial electrogram recordings in idiopathic ventricular fibrillation with inferior and lateral early repolarization. (2014)
  • Author(s): Nakagawa K, Nagase S, Morita H, Ito H.
  • Journal Title: Heart Rhythm. Volume: 11 Issue: 1 Pages: 314-317
  • DOI: 10.1186/1475-2840-13-61
  • Peer Reviewed
• [Journal Article] Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease (2014)
  • Author(s): Miyoshi T, Doi M, Usui S, Iwamoto M, Kajiya M, Takeda K, Nosaka K, Nakayama R, Okawa K, Takagi W, Nakamura K, Hirohata S, Ito H
  • Journal Title: Atherosclerosis Volume: 233(2) Issue: 2 Pages: 454-459
  • DOI: 10.1016/j.atherosclerosis.2014.01.019
  • Peer Reviewed
• [Journal Article] Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats (2014)
  • Author(s): Miyoshi T, Nakamura K, Yoshida M, Miura D, Oe H, Akagi S, Sugiyama H, Akazawa K, Yonezawa T, Wada J, Ito H
  • Journal Title: Cardiovasc Diabetol Volume: 13 Issue: 1 Pages: 43-43
  • DOI: 10.1186/1475-2840-13-43
  • Peer Reviewed
• [Journal Article] Impact of chronic kidney disease on left main coronary artery disease and prognosis in Japanese patients. (2012)
  • Author(s): Dan K, Miyoshi T, Ueeda M, Ohtsuka H, Ugawa S, Ohnishi N, Takaishi A, Nakamura K, Kusano K, Ito H.
  • Journal Title: Circ J. Volume: 76(9) Issue: 1 Pages: 2266-2272
  • DOI: 10.1161/circep.108.771139
  • NAID: 10030697155
  • Peer Reviewed
• [Journal Article] Elevated serum adipocyte fatty acid-binding protein concentrations are independently associated with renal dysfunction in patients with stable angina pectoris. (2012)
  • Author(s): Iwamoto M, Miyoshi T, Doi M, Takeda K, Kajiya M, Nosaka K, Nakamaya R, Hirohata S, Usui S, Kusachi S, Sakane K, Nakamura K, Ito H
  • Journal Title: Cardiovasc Diabetol. Volume: 11(1) Issue: 1 Pages: 26-26
  • DOI: 10.1186/1475-2840-8-51
  • Peer Reviewed
• [Presentation] Genetic Deletion of Integrin Alpha1beta1 Alleviates Aortic Rupture in Angiotensin II-induced Abdominal Aortic Aneurysm (2014)
  • Author(s): T. Miyoshi, T. Yonezawa, M. Yoshida, S. Akagi, Y. Saito, K. Nakamura, H. Ito
  • Organizer: AHA scientific session 2014
  • Place of Presentation: Chicago
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] 血管機能検査としてのCAVI (2014)
  • Author(s): 三好 亨、伊藤 浩
  • Organizer: 第37回日本高血圧学会パネルディスカッション
  • Place of Presentation: 横浜
  • Year and Date: 2014-10-17 – 2014-10-19
• [Presentation] Non-invasive Fractional Flow Reserve Computed from CT (FFRCT) Using Coronary CT Angiography (2014)
  • Author(s): 三好 亨、大澤和宏、中村一文、伊藤 浩
  • Organizer: 第62回心臓学会学術集会ビジュアルワークショップ
  • Place of Presentation: 仙台
  • Year and Date: 2014-09-26 – 2014-09-28
• [Presentation] Inhibition of DPP-4 attenuates monocyte inflammatory response through suppression of MAPK phosphorylation and ameliorates the development of CaCl2-induced abdominal aortic aneurysm in mice (2014)
  • Author(s): Y. Noda, T. Miyoshi, T. Yonezawa, M. Yoshida, K. Kohno, K. Nakamura, H. Morita, H. Ito
  • Organizer: ESC CONGRESS 2014
  • Place of Presentation: BARCELONA
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Arterial stiffness is associated with left ventricular geometry and diastolic dysfunction in the elderly (2014)
  • Author(s): Y. Ohno, T. Miyoshi, H. Oe, K. Nakamura, K. Kohno, K. Nakamura, H. Morita, H. Ito
  • Organizer: ESC CONGRESS 2014
  • Place of Presentation: BARCELONA
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Vildagliptin, a dipeptidyl peptidase-4 inhibitor, ameliorates the development of CaCl2-induced abdominal aortic aneurysm in mice via anti-inflammatory effects (2013)
  • Author(s): Y. Noda, T. Miyoshi, T. Yonezawa, H. Oe, N. Toh, Y. Oono, K. Nakamura, H. Morita, K. Kusano, H. Ito
  • Organizer: ＥＳＣ2013
  • Place of Presentation: オランダ、北ホラント州、アムステルダム
• [Presentation] Hyaluronic acid metabolism is increased in human abdominal aortic aneurysm
  • Author(s): Miyoshi T
  • Organizer: ＥＳＣ2012
  • Place of Presentation: ドイツ、バイエルン州、ミュンヘン