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The evaluation of CD44 in pathogenesis of abdominal aortic aneurysm and the development of new therapy

Research Project

Project/Area Number 24591053
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Circulatory organs internal medicine
Research InstitutionOkayama University

Principal Investigator

MIYOSHI Toru  岡山大学, 大学病院, 講師 (70444651)

Co-Investigator(Kenkyū-buntansha) NAKAMURA Kazufumi  岡山大学, 医歯薬学総合研究科, 准教授 (10335630)
YONEZAWA Tomoko  岡山大学, 医歯薬学総合研究科, 助教 (30304299)
YOSHIDA Masashi  岡山大学, 医歯薬学総合研究科, 助教 (70532761)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords腹部大動脈瘤 / CD44 / 炎症性遺伝子 / 動脈硬化 / サイトカイン / ヒアルロン酸
Outline of Final Research Achievements

Immunohistochemical analysis of human abdominal aortic aneurysm revealed that the increased expression of CD44 and the degradation of hyaluronic acid were possibly involved in pathogenesis of abdominal aortic aneurysm. Experimental abdominal aortic aneurysm using CaCl2-induced model, the incidence of abdominal aortic aneurysm was significantly less in CD44 knockout mice compared to wild type mice. Liposome targeting CD44 was developed and the utility of its liposome is being studied.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (13 results)

All 2014 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (7 results)

  • [Journal Article] Pioglitazone prevents the endothelial dysfunction induced by ischemia and reperfusion in healthy subjects2014

    • Author(s)
      Sakatani Y, Miyoshi T, Oe H, Noda Y, Ohno Y, Nakamura K, Saito Y, Osawa K, Morita H, Kohno K, Ito H
    • Journal Title

      Journal of cardiovascular pharmacology

      Volume: 64 Issue: 4 Pages: 326-331

    • DOI

      10.1097/fjc.0000000000000124

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Left ventricular epicardial electrogram recordings in idiopathic ventricular fibrillation with inferior and lateral early repolarization.2014

    • Author(s)
      Nakagawa K, Nagase S, Morita H, Ito H.
    • Journal Title

      Heart Rhythm.

      Volume: 11 Issue: 1 Pages: 314-317

    • DOI

      10.1186/1475-2840-13-61

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low serum level of secreted frizzled-related protein 5, an anti-inflammatory adipokine, is associated with coronary artery disease2014

    • Author(s)
      Miyoshi T, Doi M, Usui S, Iwamoto M, Kajiya M, Takeda K, Nosaka K, Nakayama R, Okawa K, Takagi W, Nakamura K, Hirohata S, Ito H
    • Journal Title

      Atherosclerosis

      Volume: 233(2) Issue: 2 Pages: 454-459

    • DOI

      10.1016/j.atherosclerosis.2014.01.019

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of vildagliptin, a dipeptidyl peptidase 4 inhibitor, on cardiac hypertrophy induced by chronic beta-adrenergic stimulation in rats2014

    • Author(s)
      Miyoshi T, Nakamura K, Yoshida M, Miura D, Oe H, Akagi S, Sugiyama H, Akazawa K, Yonezawa T, Wada J, Ito H
    • Journal Title

      Cardiovasc Diabetol

      Volume: 13 Issue: 1 Pages: 43-43

    • DOI

      10.1186/1475-2840-13-43

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impact of chronic kidney disease on left main coronary artery disease and prognosis in Japanese patients.2012

    • Author(s)
      Dan K, Miyoshi T, Ueeda M, Ohtsuka H, Ugawa S, Ohnishi N, Takaishi A, Nakamura K, Kusano K, Ito H.
    • Journal Title

      Circ J.

      Volume: 76(9) Issue: 1 Pages: 2266-2272

    • DOI

      10.1161/circep.108.771139

    • NAID

      10030697155

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Journal Article] Elevated serum adipocyte fatty acid-binding protein concentrations are independently associated with renal dysfunction in patients with stable angina pectoris.2012

    • Author(s)
      Iwamoto M, Miyoshi T, Doi M, Takeda K, Kajiya M, Nosaka K, Nakamaya R, Hirohata S, Usui S, Kusachi S, Sakane K, Nakamura K, Ito H
    • Journal Title

      Cardiovasc Diabetol.

      Volume: 11(1) Issue: 1 Pages: 26-26

    • DOI

      10.1186/1475-2840-8-51

    • Related Report
      2012 Research-status Report
    • Peer Reviewed
  • [Presentation] Genetic Deletion of Integrin Alpha1beta1 Alleviates Aortic Rupture in Angiotensin II-induced Abdominal Aortic Aneurysm2014

    • Author(s)
      T. Miyoshi, T. Yonezawa, M. Yoshida, S. Akagi, Y. Saito, K. Nakamura, H. Ito
    • Organizer
      AHA scientific session 2014
    • Place of Presentation
      Chicago
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] 血管機能検査としてのCAVI2014

    • Author(s)
      三好 亨、伊藤 浩
    • Organizer
      第37回日本高血圧学会パネルディスカッション
    • Place of Presentation
      横浜
    • Year and Date
      2014-10-17 – 2014-10-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Non-invasive Fractional Flow Reserve Computed from CT (FFRCT) Using Coronary CT Angiography2014

    • Author(s)
      三好 亨、大澤和宏、中村一文、伊藤 浩
    • Organizer
      第62回心臓学会学術集会ビジュアルワークショップ
    • Place of Presentation
      仙台
    • Year and Date
      2014-09-26 – 2014-09-28
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inhibition of DPP-4 attenuates monocyte inflammatory response through suppression of MAPK phosphorylation and ameliorates the development of CaCl2-induced abdominal aortic aneurysm in mice2014

    • Author(s)
      Y. Noda, T. Miyoshi, T. Yonezawa, M. Yoshida, K. Kohno, K. Nakamura, H. Morita, H. Ito
    • Organizer
      ESC CONGRESS 2014
    • Place of Presentation
      BARCELONA
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Arterial stiffness is associated with left ventricular geometry and diastolic dysfunction in the elderly2014

    • Author(s)
      Y. Ohno, T. Miyoshi, H. Oe, K. Nakamura, K. Kohno, K. Nakamura, H. Morita, H. Ito
    • Organizer
      ESC CONGRESS 2014
    • Place of Presentation
      BARCELONA
    • Year and Date
      2014-08-30 – 2014-09-03
    • Related Report
      2014 Annual Research Report
  • [Presentation] Vildagliptin, a dipeptidyl peptidase-4 inhibitor, ameliorates the development of CaCl2-induced abdominal aortic aneurysm in mice via anti-inflammatory effects2013

    • Author(s)
      Y. Noda, T. Miyoshi, T. Yonezawa, H. Oe, N. Toh, Y. Oono, K. Nakamura, H. Morita, K. Kusano, H. Ito
    • Organizer
      ESC2013
    • Place of Presentation
      オランダ、北ホラント州、アムステルダム
    • Related Report
      2013 Research-status Report
  • [Presentation] Hyaluronic acid metabolism is increased in human abdominal aortic aneurysm

    • Author(s)
      Miyoshi T
    • Organizer
      ESC2012
    • Place of Presentation
      ドイツ、バイエルン州、ミュンヘン
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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