High circulating S100A12 is a predictor for cardiovascular mortality in ESRD patients.

• Project/Area Number: 24591078
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Circulatory organs internal medicine
• Research Institution: Setsunan University
• Principal Investigator: KOSAKI Atsushi 摂南大学, 看護学部, 教授 (40330188)
• Co-Investigator(Kenkyū-buntansha): MORI Yasukiyo 京都府立医科大学, 医学研究科 (40268371)
• Project Period (FY): 2012-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: S100A12 / 心血管障害 / 末期腎臓病 / 動脈硬化 / Ｓ１００Ａ１２ / 心血管イベント / 末期腎不全 / 血管平滑筋細胞 / 石灰化 / 慢性炎症

Outline of Final Research Achievements

Background and Design: S100A12 is an endogenous receptor ligand for advanced glycation end products. Cardiovascular disease remains a major cause of morbidity and mortality in patients with chronic kidney disease. In this study, we report two-year prospective study on 847 hemodialysis patients and assess the relationship between plasma S100A12 level and cardiovascular disease. We investigated the onset or death of cardiovascular disease as an endpoint.
Results: During the follow-up, 35 cardiovascular deaths were occurred. S100A12 level, measured at baseline, was significantly elevated in dead patients compared with survived patients. Cumulative incidence of cardiovascular death by Kaplan-Meier estimation was significantly higher in the higher half of plasma S100A12 than in the lower half.
Conclusions: Plasma S100A12 is elevated in the cardiovascular dead, and high circulating S100A12 is a predictor for cardiovascular mortality in ESRD patients.

Research Products

• [Journal Article] Prognostic utility of plasma S100A12 levels to establish a novel scoring system for predicting mortality in maintenance hemodialysis patients: a two-year prospective observational study in Japan. (2013)
  • Author(s): Shiotsu Y, Mori Y, Nishimura M, Hatta T, Imada N, Maki N, Iida K, Iwamoto N, Matsuoka E, Tamagaki K, Kosaki A.
  • Journal Title: BMC Nephrol. Volume: 16 Issue: 1 Pages: 1-9
  • DOI: 10.1186/1471-2369-14-16
  • Peer Reviewed
• [Presentation] S100A12 protein induces the proliferation and calcification of smooth muscle cells (2013)
  • Author(s): Eiko Matsuoka, Yasukiyo Mori, Atsushi Kosaki
  • Organizer: 81st European Atherosclerosis Society Congress (EAS2013)
  • Place of Presentation: Lyon, France
• [Presentation] Prognostic Utility of Plasma S100A12 Levels in Maintenance Hemodialysis Patients.: A Novel Score System for Predicting Mortality. (2012)
  • Author(s): Shiotsu Y, Mori Y, Matsuoka E, Tamagaki K, Kosaki A.
  • Organizer: 米国腎臓学会（ASN Kidney Week 2012）
  • Place of Presentation: San Diego, CA, USA