| Project/Area Number |
24591086
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
AIBA Takeshi 独立行政法人国立循環器病研究センター, 病院, 医長 (40574348)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Wataru 日本医科大学, 循環器内科, 教授 (50399606)
TAKAKI Hiroshi 国立循環器病研究センター, 研究所循環動態制御部, 室長 (80197053)
MATSUURA Hiroshi 滋賀医科大学, 医学部・細胞機能生理学, 教授 (60238962)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | Brugada syndrome / genetics / sudden death / electrophysiology / Na channels / ventricular fibrillation / 心室細動 / 突然死 / ﾌﾞﾙｶﾞﾀﾞ症候群 / 遺伝子 / イオンチャネル / ブルガダ症候群 / ナトリウム / 不整脈 / J波 |
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| Outline of Final Research Achievements |
We reported that common variants at SCN5A-SCN10A and HEY2 are associated with a high risk of sudden cardiac death (SCD) in Brugada syndrome, and a nonsynonymous polymorphism in semaphorin 3A as a risk factor for SCD due to VF. The genetic defects in a His-Purkinje system transcription factor, IRX3, are associated with lethal cardiac arrhythmias in conjunction with Na channel defect. These findings suggest that Brugada or related sudden arrhythmic death syndrome are not a monogenic disease but associated with multiple mechanisms.
We also non-invasively evaluated risk of sudden arrhythmic death in the Brugada or J-wave syndrome using standard 12-lead ECG and multi-channel magnetocardiography (MCG).
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