| Project/Area Number |
24591088
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
NOGUCHI Teruo 独立行政法人国立循環器病研究センター, 病院, 部長 (70505099)
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA Satoshi 国立循環器病研究センター, 病院, 部門長 (00431578)
IIDA Hidehiro 国立循環器病研究センター, 研究所, 部長 (30322720)
YAMADA Naoaki 国立循環器病研究センター, 病院, 医師 (40393219)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | plaque / magnetic resonance / imaging / acute coronary syndrome / 不安定プラーク / 画像診断 / ＭＲＩ / 急性冠症候群 / coronary plaque / イメージング / 動脈硬化 |
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| Outline of Final Research Achievements |
We have previously shown that the presence of coronary high-intensity plaques (HIPs) detected by non-contrast T1WI is associated with positive coronary artery remodeling, low density on computed tomography angiography (CTA), and ultrasound attenuation. In addition, HIPs can be uniquely assessed using a plaque to myocardium signal intensity ratio (PMR). We demonstrates that HIPs identified by non-contrast T1WI are significantly associated with coronary events and may thus a promising predictive factor in patients at high risk. Moreover,we shows that intensive statin therapy reduces HIP-PMR identified by non-contrast T1WI, which may represent a useful method for quantitatively monitoring changes in plaque vulnerability.
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