Development of new intervention by nutritional rehabilitation in COPD

• Project/Area Number: 24591124
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: Akita University
• Principal Investigator: SHIOYA Takanobu 秋田大学, 医学(系)研究科(研究院), 教授 (90170852)
• Co-Investigator(Kenkyū-buntansha): SATAKE Masahiro 秋田大学, 大学院医学系研究科, 准教授 (10250903) ; WATANABE Hiroyuki 秋田大学, 大学院医学系研究科, 准教授 (80323145) ; SANO Masaaki 秋田大学, 大学院医学系研究科, 講師 (30323140)
• Research Collaborator: TAKAHASHI Hitomi 市立秋田総合病院, リハビリ科, 技師長 ; SUGAWARA Keiyu 市立秋田総合病院, リハビリ科, 副技師長 ; KAWAGOSHI Atsuyoshi 市立秋田総合病院, リハビリ科, 技師
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 栄養リハビリテーション / 呼吸リハビリテーション / 運動療法 / 栄養療法 / 慢性閉塞性肺疾患(COPD) / サルコペニア / 身体組成 / 身体活動 / 栄養リハビリ / 栄養補充療法 / 健康関連QOL / 日常生活活動

Outline of Final Research Achievements

The aim of this study was to investigate the effectiveness of nutritional supplementation therapy with low-intensity exercise therapy in patients with COPD. In stable elderly COPD patients, anti-inflammatory nutritional supplementation therapy was added to low-intensity exercise therapy. COPD patients were divided into those with and those without the ingestion of nutritional supplement containing whey peptide, which exhibited an anti-inflammatory effect. The body composition, skeletal muscle strength, exercise tolerance, health-related QOL (HRQOL), and inflammatory cytokines were evaluated before and three months after intervention. In the nutritional support group, the body weight, lower muscle force, respiratory muscle force and CRQ score were significantly increased, and the levels of inflammatory cytokines were reduced significantly. These data suggested usefulness of nutritional rehabilitation which was consisted of nutritional therapy and exercise therapy.

Research Products

• [Journal Article] Dynamic hyperinflation and dyspnea during the 6-minute walk test in stable chronic obstructive pulmonary disease patients. (2015)
  • Author(s): Satake, M, Shioya, T, Uemura, S, Takahashi, H, Sugawara, K, Kasai, C, Kiyokawa, N, Watanabe, T, Sato, S, Kawagoshi, A.
  • Journal Title: Int J COPD Volume: 10 Pages: 153-158
  • Peer Reviewed
• [Journal Article] Kawagoshi, A, Kiyokawa, N, Sugawara, K, Takahashi, H, Sakata, S, SEffects of low-intensity exercise and home-based pulmonary rehabilitation with pedometer feedback on physical activity in elderly patients with chronic obstructive pulmonary disease. (2015)
  • Author(s): Kawagoshi, A, Kiyokawa, N, Sugawara, K, Takahashi, H, Sakata, S, Satake, M, Shioya, T.
  • Journal Title: Respir Med. Volume: 109 Issue: 3 Pages: 364-371
  • DOI: 10.1016/j.rmed.2015.01.008
  • Peer Reviewed / Open Access
• [Journal Article] 3軸加速度計システムを用いた自転車駆動時間の測定の信頼性に関する検討． (2015)
  • Author(s): 伊藤あずさ，岩倉正浩，佐藤瑞騎，坂田俊一，佐竹將宏，塩谷隆信．
  • Journal Title: 秋田大学大学院医学系研究科保健学専攻紀要 Volume: 23 Pages: 31-37
• [Journal Article] Measurement of the wheelchair-operating time spent by stroke patients using a new triaxial accelerometer system. (2014)
  • Author(s): Terui, Y, Shioya, T, Hasegawa, K, Suto, E, Kawagoshi, A, Satake, M, Sawamura, S, Sakata, S.
  • Journal Title: Open J Ther Rehab Volume: 2 Pages: 147-155
  • Peer Reviewed / Open Access
• [Journal Article] 高負荷圧吸気筋トレーニングが若年競泳選手のパフォーマンス向上へ及ぼす効果． (2014)
  • Author(s): 大倉和貴，甲斐 学，川越厚良，菅原慶勇，高橋仁美，塩谷隆信．
  • Journal Title: 日呼ケア・リハ学誌 Volume: 24 Pages: 268-274
  • NAID: 130005109132
  • Peer Reviewed
• [Journal Article] 慢性閉塞性肺疾患でみられる経過中の体重減少に関する因子の検討とその対策についての研究 (2013)
  • Author(s): 菅原慶勇，高橋仁美，柏倉剛，本間光信，塩谷隆信
  • Journal Title: 日呼ケア・リハ学誌 Volume: 22 Pages: 264-270
  • NAID: 130005147850
  • Peer Reviewed
• [Journal Article] 6分間ペグボード•リング試験によるCOPD患者の呼吸循環反応と上肢運動機能の評価 (2013)
  • Author(s): 照井佳乃，川越厚良，葛巻 歩，菅原慶勇，高橋仁美，柏倉 剛，本間光信，河崎雄司，佐竹將宏，塩谷隆信
  • Journal Title: 理学療法学 Volume: 40 Pages: 24-32
  • NAID: 110009594480
  • Peer Reviewed
• [Journal Article] International COPD Coalition Column: pulmonary rehabilitation-reaching out to our international community (2013)
  • Author(s): Garvey, C, Spruit, MA, Hill, K, Pitta, F, Shioya, T
  • Journal Title: J Thorac Dis Volume: 10 Pages: 2072-2075
  • Peer Reviewed
• [Journal Article] COPD患者では気腫性病変が多いとやせが強いーNetter pink pufferの重要性ー (2013)
  • Author(s): 塩谷隆信，佐竹將宏，進藤勉，佐藤一洋，佐野正明，齊藤元，川越厚良，菅原慶勇，高橋仁美，平野義則，伊藤武史，伊藤伸明，本間光信
  • Journal Title: 日呼ケア・リハ学誌 Volume: 23 Pages: 241-248
  • NAID: 130005123201
  • Peer Reviewed
• [Journal Article] 肺葉切除における術前呼吸リハビリテーションと術後呼吸機能に関する検討 (2013)
  • Author(s): 齊藤元，塩谷隆信，佐藤峰善，畠山和利，渡邉基起，松永俊樹，島田洋一，今井一博，折野公人，戸沢香澄，橋本正治，南谷佳弘
  • Journal Title: 秋田医学 Volume: 40 Pages: 105-112
  • NAID: 110009658222
  • Peer Reviewed
• [Journal Article] Dysphagia causes exercerbations in patients with chronic obstructive pulmonary disease. (2012)
  • Author(s): Tsuzuki, A, Kagaya, A, Takahashi, H, Watanabe, T, Shioya, T, Sakakibara, H, Kanada, Y, Saitoh, E
  • Journal Title: J Am Geriatr Soc Volume: 60 Pages: 1580-1582
  • Peer Reviewed
• [Journal Article] Effect of anti-inflammatory supplementation with whey peptide and exercise therapy in patients with COPD (2012)
  • Author(s): ugawara, K, Takahashi, H, Kasai, C, Kiyokawa, N, Watanabe, T, Fujii, S, Kashiwagura, T, Homma, M, Satake, M, Shioya, T
  • Journal Title: Respiratoy Medicine Volume: 106 Pages: 1526-1534
  • Peer Reviewed
• [Presentation] Measurement of the wheelchair-operating time in daily living using a triaxial accerlerometer system. (2014)
  • Author(s): Terui, Y, Shioya, T, Hasegawa, K, Sato, E, Kawagoshi, A, Satake, M, Sawamura, S, Sakata, S.
  • Organizer: 19th Congress of APSR
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2014-11-14 – 2014-11-26
• [Presentation] Relationship between nocturnal oxygen saturation and function of diaphragm assessed by ultrasonography in COPD. (2014)
  • Author(s): .Ohkura, K, Kawagoshi, A, Sugawara, K, Takahashi, H, Satake, M, Sioya, T.
  • Organizer: 19th Congress of APSR
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] Recovery process after 6-minute walk test in stable COPD patients. (2014)
  • Author(s): Satake, M, Shioya, T, Takahashi, H, Sugawara, K, Kasai, C, Kiyokawa, N, Watanabe, T, Sato, S, Kawagoshi, A.
  • Organizer: 19th Congress of APSR
  • Place of Presentation: Bali, Indonesia
  • Year and Date: 2014-11-14 – 2014-11-16
• [Presentation] 呼吸リハと歩数計による患者教育が高齢COPD患者の身体活動量に与える上乗せ効果． (2014)
  • Author(s): 川越厚良，清川憲孝，菅原慶勇，高橋仁美，柏倉剛，佐竹將宏，塩谷隆信．
  • Organizer: 第24回日本呼吸ケア・リハビリ学会
  • Place of Presentation: なら百年会館，奈良
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] 缶詰―棚上げ試験（GST）によるCOPD患者の呼吸循環反応と上肢運動機能評価としての有用性の検討 (2014)
  • Author(s): 佐藤瑞騎，倉田昌一，米沢将和，進藤 侑，岩倉正浩，伊藤あずさ，川越厚良，照井佳乃，佐竹將宏，塩谷隆信
  • Organizer: 第24回日本呼吸ケア・リハビリ学会
  • Place of Presentation: なら百年会館，奈良
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] COPDにおけるLABA/LAMAの気管支拡張効果―単剤併用と配合薬の比較― (2014)
  • Author(s): 塩谷隆信，佐竹將宏，菅原慶勇，高橋仁美，三浦絵美理，伊藤武史，伊藤伸明，本間光信
  • Organizer: 第24回日本呼吸ケア・リハビリ学会
  • Place of Presentation: なら百年会館，奈良
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] COPD患者の6分間歩行試験直後の回復過程についてー呼気ガスと経皮的動脈血酸素飽和度と呼吸困難の経過ー (2014)
  • Author(s): 佐竹將宏，塩谷隆信，高橋仁美，菅原慶勇，笠井千景，清川憲孝，渡邊暢，佐藤清佳，川越厚良
  • Organizer: 第24回日本呼吸ケア・リハビリ学会
  • Place of Presentation: なら百年会館，奈良
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] %IBW90%未満の安定期COPD患者の栄養補給療法後の体重増減からみた検討 (2014)
  • Author(s): 山田公子，大山久仁子，菅原慶勇，高橋仁美，本間光信，津田徹，武田博明，河﨑雄司，塩谷隆信
  • Organizer: 第24回日本呼吸ケア・リハビリ学会
  • Place of Presentation: なら百年会館，奈良
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] 3軸加速度系による四つ這い時間測定方法の検討：COPD患者への応用を目指して． (2014)
  • Author(s): 岩倉正浩，佐藤瑞騎，伊藤あずさ，坂田俊一，川越厚良，佐竹將宏，菅原慶勇，高橋仁美，塩谷隆信．
  • Organizer: 第24回日本呼吸ケア・リハビリ学会
  • Place of Presentation: なら百年会館，奈良
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] 6分間歩行距離の健常者予測値の検討 (2014)
  • Author(s): 柴田和幸，大倉和貴，岩倉正浩，菅原慶勇，高橋仁美，塩谷隆信
  • Organizer: 第24回日本呼吸ケア・リハビリ学会
  • Place of Presentation: なら百年会館，奈良
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] Effect of home-based pulmonary rehabilitation on the time spent in active- and passive-walking time in elderly patients with COPD. (2013)
  • Author(s): Kawagoshi, A, Miura, S, Kiyokawa, N, Sugawara, K, Takahashi, H, Sawamura, S, Sakata, S, Kashiwagura, T, Homma, M, Satake, M, Shioya, T.
  • Organizer: 2013 Annual Meeting American Thoracic Society
  • Place of Presentation: Philadelphia, PN, USA
• [Presentation] Physcal activities in stable COPD patients with and without home oxygen therapy (2013)
  • Author(s): Kaneko, N, Kawagoshi, A, Kiyokawa, N, Sugawara, K, Takahashi, H, Abe, R, Sakata, S, Shioya, T.
  • Organizer: 2013 Annual Meeting American Thoracic Society
  • Place of Presentation: Philadelphia, PN, USA
• [Presentation] Effectiveness of new respiratory muscle training in patients with COPD (2013)
  • Author(s): Ohkura, K, Kai, M, Kamwagoshi, A, Sugawara, K, Takahashi, H, Satake, M, Shioya, T.
  • Organizer: 18th Congress of APSR
  • Place of Presentation: Yokohama, Japan
• [Presentation] 呼吸リハビリテーションの新展開―身体活動の向上を目指して― (2013)
  • Author(s): 塩谷隆信，佐竹將宏，高橋仁美
  • Organizer: 第23回日本呼吸ケア・リハビリテーション学会
  • Place of Presentation: 東京ドームホテル，東京
  • Invited
• [Presentation] 安定期COPD患者に対する栄養補給療法の効果：多施設共同前向き研究 (2013)
  • Author(s): 山田公子，大山久仁子，佐藤綾己，菅原慶勇，高橋仁美，本間光信，津田徹，武田博明，河﨑雄司，塩谷隆信
  • Organizer: 第23回日本呼吸ケア・リハビリ学会
  • Place of Presentation: 東京ドームホテル，東京
• [Presentation] 栄養療法を上乗せした安定期慢性閉塞性肺疾患患者における病期別効果の比較 (2013)
  • Author(s): 菅原慶勇，高橋仁美，大山久仁子，山田公子，佐藤綾己，本間光信，津田徹，武田博明，河﨑雄司，塩谷隆信
  • Organizer: 第23回日本呼吸ケア・リハビリ学会
  • Place of Presentation: 東京ドームホテル，東京
• [Presentation] 安定期COPD患者における抗炎症作用を有する栄養補助食品の併用効果
  • Author(s): 塩谷隆信，佐竹將宏，菅原慶勇，高橋仁美，本間光信
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸コンベンションセンター
• [Presentation] 外来呼吸リハビリ施行中の安定期COPD患者における身体活動量の継時的変化
  • Author(s): 川越厚良，清川憲孝，菅原慶勇，高橋仁美．本間光信，佐竹將宏，塩谷隆信
  • Organizer: 第22回日本呼吸ケア・リハビリ学会
  • Place of Presentation: 福井フェニックス・プラザ
• [Presentation] COPD患者では気腫性病変が広いとやせが強いーNetter A タイプの重要性ー
  • Author(s): 塩谷隆信，佐竹將宏，川越厚良，佐藤清佳，清川憲孝，笠井千景，菅原慶勇，高橋仁美，平野義則，本間光信
  • Organizer: 第22回日本呼吸ケア・リハビリ学会
  • Place of Presentation: 福井フェニックス・プラザ
• [Presentation] COPD患者の6分間歩行試験における換気効率の検討
  • Author(s): 佐竹將宏，塩谷隆信，高橋仁美，菅原慶勇，笠井千景．清川憲孝，渡邊暢，川越厚良
  • Organizer: 第22回日本呼吸ケア・リハビリ学会
  • Place of Presentation: 福井フェニックス・プラザ
• [Presentation] 慢性閉塞性肺疾患の現状ならびに低強度運動療法と栄養療法の併用効果
  • Author(s): 菅原慶勇，塩谷隆信
  • Organizer: 第22回日本呼吸ケア・リハビリ学会
  • Place of Presentation: 福井フェニックス・プラザ
• [Presentation] Ventilatory responses during 6-min walk test in stable COPD patients
  • Author(s): Satake, M, Shioya, T, Takahashi, H, Sugawara, K, Kasai, C, Kiyokawa, N, Watanabe, T, Sato, S, Kawagoshi, A, Homma, M
  • Organizer: 22th ERS Annual Congress
  • Place of Presentation: Vienna, Austria
• [Presentation] Effects of home-based pulmonary rehabilitation on the time spent inn active- and passive walking in elderly patients with COPD
  • Author(s): Kawagoshi, A, Kiyokawa, N, Sugawara, K, Takahashi, H, Kashiwagura, T, Homma, M, Sakata, S, Satake, M, Shioya, T
  • Organizer: 22th ERS Annual Congress
  • Place of Presentation: Vienna, Austria,
• [Book] 呼吸のトリビア３ーレスピサイエンスー (2014)
  • Author(s): 塩谷隆信，千原幸司，桑平一郎，小林弘祐
  • Total Pages: 163
  • Publisher: 中外医学社
• [Book] 呼吸リハビリテーション最前線ー身体活動の向上とその実践ー (2014)
  • Author(s): 塩谷隆信，高橋仁美
  • Total Pages: 223
  • Publisher: 医歯薬出版社
• [Book] 動画でわかる呼吸リハビリテーション第３版 (2013)
  • Author(s): 柳田仁子，山田公子，菅原慶勇，塩谷隆信
  • Total Pages: 301
  • Publisher: 中山書店
• [Book] 包括的呼吸リハビリテーション ー現状と将来展望ー (2013)
  • Author(s): 塩谷隆信，佐竹將宏，川越厚良，菅原慶勇，高橋仁美
  • Publisher: 総合リハビリテーション（医学書院）
• [Book] 正常な呼吸器系の解剖とメカニズム (2013)
  • Author(s): 塩谷隆信
  • Publisher: リハビリナース（メディカ出版）
• [Book] COPDの呼吸ケア・リハビリテーション (2012)
  • Author(s): 塩谷隆信，佐竹將宏，玉木彰，川越厚良，菅原慶勇，高橋仁美
  • Publisher: 呼吸器科（科学評論社）