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The usefulness of the lung sound analysis in evaluating the effect of endoscopic lung volume reduction.

Research Project

Project/Area Number 24591143
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

MINESHITA Masamichi  聖マリアンナ医科大学, 医学部, 准教授 (70440336)

Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Keywords呼吸音解析 / 慢性閉塞性肺疾患 / 内視鏡的肺容量減量術 / 呼吸音 / 気管支鏡的肺容量減量術 / 肺容量減量術
Outline of Final Research Achievements

We planned to study the usefulness of the lung sound analysis in evaluating the effect of endoscopic lung volume reduction for COPD patients. We reported lung sound analysis in healthy Japanese subjects, the effects of bronchodilators on regional lung sound distribution in COPD patients, and the correlation between lung sound distribution and pulmonary function in COPD patients. We also reported the regional lung sound asynchrony in COPD patients.
We found that the ratio of lower- to upper-lung sound intensities decreased according to the severity of obstructive changes in COPD patients. The additional use of an SABA by COPD patients improved their pulmonary function, which was accompanied by changes in regional lung air flow. We also found the regional lung sound distributed more asynchronously in COPD than in healthy smokers, and the heterogeneous distribution of emphysematous lesions seemed to be one of the causes of regional lung sound asynchrony.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (18 results)

All 2015 2014 2013 2012

All Journal Article (9 results) (of which Peer Reviewed: 6 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (8 results) Book (1 results)

  • [Journal Article] The correlation between lung sound distribution and pulmonary function in COPD patients.2014

    • Author(s)
      Mineshita M, Kida H, Handa H, Nishine H, Furuya N, Nobuyama S, Inoue T, Matsuoka S, Miyazawa T.
    • Journal Title

      PLoS One.

      Volume: 22 Issue: 9 Pages: e107506-e107506

    • DOI

      10.1371/journal.pone.0107506

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Bronchoscopic Interventions for Chronic Obstructive Pulmonary Disease.2014

    • Author(s)
      Mineshita M, Slebos DJ.
    • Journal Title

      Respirology

      Volume: 9 Issue: 8 Pages: 1126-37

    • DOI

      10.1111/resp.12362

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Left and right lung asynchrony as a physiological indicator for unilateral bronchial obstruction in2014

    • Author(s)
      Mineshita M, Kida H, Nishine H, Handa H, Inoue T, Miyazawa T.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 8 Pages: e105327-e105327

    • DOI

      10.1371/journal.pone.0105327

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Vibration response imaging in healthy Japanese subjects.2014

    • Author(s)
      Mineshita M, Shirakawa T, Saji J, Handa H, Furuya N, Kida H, Nishine H, Nobuyama S, Inoue T, Miyazawa T
    • Journal Title

      Respir Investig.

      Volume: 52(1) Issue: 1 Pages: 28-35

    • DOI

      10.1016/j.resinv.2013.05.008

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effects of bronchodilators on regional lung sound distribution in patients with chronic obstructive pulmonary disease.2014

    • Author(s)
      Mineshita M, Matsuoka S, Miyazawa T.
    • Journal Title

      Respiration

      Volume: 87(1) Issue: 1 Pages: 45-53

    • DOI

      10.1159/000350228

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 慢性閉塞性肺疾患に対する気管支鏡的肺容量減量術2014

    • Author(s)
      峯下昌道、村岡弘海、岡本真理子、薄場彩乃、井上哲兵、森川慶、古屋直樹、半田寛、木田博隆、西根広樹、石田敦子、延山誠一、井上健男、宮澤輝臣
    • Journal Title

      聖マリアンナ医学雑誌

      Volume: 41 Pages: 173-185

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] 最新の気管支インターベンション2013

    • Author(s)
      峯下昌道
    • Journal Title

      Respiratory Medical Research

      Volume: 1 Pages: 64-67

    • Related Report
      2013 Research-status Report
  • [Journal Article] 喘息とCOPDに対する気管支インターベンション2013

    • Author(s)
      峯下昌道
    • Journal Title

      分子呼吸器病

      Volume: 17 Pages: 39-41

    • Related Report
      2012 Research-status Report
  • [Journal Article] 内視鏡的COPD治療-現状と展望2012

    • Author(s)
      峯下昌道、宮澤輝臣
    • Journal Title

      臨床呼吸生理

      Volume: 44 Pages: 39-44

    • Related Report
      2012 Research-status Report
  • [Presentation] COPDにおける局所呼吸音の非同期性について2015

    • Author(s)
      峯下昌道,阿座上真哉,柿沼一隆,村岡弘海,岡本真理子,薄場彩乃,井上哲兵,
    • Organizer
      第55回日本呼吸器学会学術講演会
    • Place of Presentation
      東京国際フォーラム(東京都千代田区)
    • Year and Date
      2015-04-17 – 2015-04-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] The correlation between lung sound distribution and pulmonary function in COPD patients is influenced by emphysematous lesions2014

    • Author(s)
      Mineshita M, Kida H, Handa H, Nishine H , Furuya N, Nobuyama S, Inoue T, Matsuoka S, Miyazawa T
    • Organizer
      ERS 2014
    • Place of Presentation
      ミュンヘン(ドイツ)
    • Year and Date
      2014-09-08
    • Related Report
      2014 Annual Research Report
  • [Presentation] COPDにおける呼吸音分布と肺機能の検討2014

    • Author(s)
      峯下昌道,木田博隆,古屋直樹,半田寛,西根広樹,石田敦子,延山誠一,井上健男,宮澤輝臣
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪国際会議場(大阪府大阪市)
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Assessment of regional breath sound distribution and asynchrony using vibration response imaging in central airway obstruction before and after interventional bronchoscopy2013

    • Author(s)
      Masamichi Mineshita, Hirotaka Kida, Hiroshi Handa, Naoki Furuya, Hiroki Nishine, Seiichi Nobuyama, Takeo Inoue, Teruomi Miyazawa
    • Organizer
      American Thoracic Society 2013
    • Place of Presentation
      Philadelphia
    • Related Report
      2013 Research-status Report
  • [Presentation] The effects of bronchodilators on regional lung sound distribution in patients with COPD2013

    • Author(s)
      Masamichi Mineshita, Mariko Okamoto, Ayane Tsukune, Teppei Inoue, Kei Morikawa, Naoki Furuya, Hiroshi Handa, Hirotaka Kida, Hiroki Nishine, Seiichi Nobuyama, Takeo Inoue, Shin Matsuoka,Teruomi Miyazawa
    • Organizer
      European Respiratory Society 2013
    • Place of Presentation
      Barcelona
    • Related Report
      2013 Research-status Report
  • [Presentation] 中枢気道狭窄に対する気管支インターベンション前後における呼吸音分布のVibration Response Imaging (VRI) による評価2013

    • Author(s)
      峯下昌道、木田博隆、西根広樹、半田寛、井上健男、宮澤輝臣
    • Organizer
      第五回呼吸機能イメージング研究会
    • Place of Presentation
      徳島
    • Related Report
      2012 Research-status Report
  • [Presentation] 気腫型COPDに対する気管支内一方向弁留置術と気管支喘息に対する気管支熱形成術2012

    • Author(s)
      峯下昌道
    • Organizer
      第52回日本呼吸器学会学術講演会
    • Place of Presentation
      神戸
    • Related Report
      2012 Research-status Report
  • [Presentation] Vibration response imaging (VRI) in the diagnose and outcome assessments of interventional bronchoscopy in cases with central airway obstruction2012

    • Author(s)
      Masamichi Mineshita, Hiroki Nishine, Hiroshi Handa, Hirotaka Kida, Seiichi Nobuyama, Takeo Inoue, Teruomi Miyazaw
    • Organizer
      17th World Congress for Bronchology and Interventional Pulmonology
    • Place of Presentation
      クリーブランド
    • Related Report
      2012 Research-status Report
  • [Book] 気管支鏡ベストテクニック2012

    • Author(s)
      浅野文祐、宮澤輝臣編
    • Total Pages
      247
    • Publisher
      中外医学社
    • Related Report
      2012 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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