The usefulness of the lung sound analysis in evaluating the effect of endoscopic lung volume reduction.

• Project/Area Number: 24591143
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Respiratory organ internal medicine
• Research Institution: St. Marianna University School of Medicine
• Principal Investigator: MINESHITA Masamichi 聖マリアンナ医科大学, 医学部, 准教授 (70440336)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2013: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000); Fiscal Year 2012: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
• Keywords: 呼吸音解析 / 慢性閉塞性肺疾患 / 内視鏡的肺容量減量術 / 呼吸音 / 気管支鏡的肺容量減量術 / 肺容量減量術

Outline of Final Research Achievements

We planned to study the usefulness of the lung sound analysis in evaluating the effect of endoscopic lung volume reduction for COPD patients. We reported lung sound analysis in healthy Japanese subjects, the effects of bronchodilators on regional lung sound distribution in COPD patients, and the correlation between lung sound distribution and pulmonary function in COPD patients. We also reported the regional lung sound asynchrony in COPD patients.
We found that the ratio of lower- to upper-lung sound intensities decreased according to the severity of obstructive changes in COPD patients. The additional use of an SABA by COPD patients improved their pulmonary function, which was accompanied by changes in regional lung air flow. We also found the regional lung sound distributed more asynchronously in COPD than in healthy smokers, and the heterogeneous distribution of emphysematous lesions seemed to be one of the causes of regional lung sound asynchrony.

Research Products

• [Journal Article] The correlation between lung sound distribution and pulmonary function in COPD patients. (2014)
  • Author(s): Mineshita M, Kida H, Handa H, Nishine H, Furuya N, Nobuyama S, Inoue T, Matsuoka S, Miyazawa T．
  • Journal Title: PLoS One. Volume: 22 Issue: 9 Pages: e107506-e107506
  • DOI: 10.1371/journal.pone.0107506
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Bronchoscopic Interventions for Chronic Obstructive Pulmonary Disease. (2014)
  • Author(s): Mineshita M, Slebos DJ.
  • Journal Title: Respirology Volume: 9 Issue: 8 Pages: 1126-37
  • DOI: 10.1111/resp.12362
  • Peer Reviewed / Open Access
• [Journal Article] Left and right lung asynchrony as a physiological indicator for unilateral bronchial obstruction in (2014)
  • Author(s): Mineshita M, Kida H, Nishine H, Handa H, Inoue T, Miyazawa T．
  • Journal Title: PLoS One Volume: 9 Issue: 8 Pages: e105327-e105327
  • DOI: 10.1371/journal.pone.0105327
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Vibration response imaging in healthy Japanese subjects. (2014)
  • Author(s): Mineshita M, Shirakawa T, Saji J, Handa H, Furuya N, Kida H, Nishine H, Nobuyama S, Inoue T, Miyazawa T
  • Journal Title: Respir Investig. Volume: 52(1) Issue: 1 Pages: 28-35
  • DOI: 10.1016/j.resinv.2013.05.008
  • Peer Reviewed
• [Journal Article] Effects of bronchodilators on regional lung sound distribution in patients with chronic obstructive pulmonary disease. (2014)
  • Author(s): Mineshita M, Matsuoka S, Miyazawa T.
  • Journal Title: Respiration Volume: 87(1) Issue: 1 Pages: 45-53
  • DOI: 10.1159/000350228
  • Peer Reviewed
• [Journal Article] 慢性閉塞性肺疾患に対する気管支鏡的肺容量減量術 (2014)
  • Author(s): 峯下昌道、村岡弘海、岡本真理子、薄場彩乃、井上哲兵、森川慶、古屋直樹、半田寛、木田博隆、西根広樹、石田敦子、延山誠一、井上健男、宮澤輝臣
  • Journal Title: 聖マリアンナ医学雑誌 Volume: 41 Pages: 173-185
  • Peer Reviewed
• [Journal Article] 最新の気管支インターベンション (2013)
  • Author(s): 峯下昌道
  • Journal Title: Respiratory Medical Research Volume: 1 Pages: 64-67
• [Journal Article] 喘息とCOPDに対する気管支インターベンション (2013)
  • Author(s): 峯下昌道
  • Journal Title: 分子呼吸器病 Volume: 17 Pages: 39-41
• [Journal Article] 内視鏡的COPD治療－現状と展望 (2012)
  • Author(s): 峯下昌道、宮澤輝臣
  • Journal Title: 臨床呼吸生理 Volume: 44 Pages: 39-44
• [Presentation] COPDにおける局所呼吸音の非同期性について (2015)
  • Author(s): 峯下昌道，阿座上真哉，柿沼一隆，村岡弘海，岡本真理子，薄場彩乃，井上哲兵，
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京国際フォーラム（東京都千代田区）
  • Year and Date: 2015-04-17 – 2015-04-19
• [Presentation] The correlation between lung sound distribution and pulmonary function in COPD patients is influenced by emphysematous lesions (2014)
  • Author(s): Mineshita M, Kida H, Handa H, Nishine H , Furuya N, Nobuyama S, Inoue T, Matsuoka S, Miyazawa T
  • Organizer: ERS 2014
  • Place of Presentation: ミュンヘン（ドイツ）
  • Year and Date: 2014-09-08
• [Presentation] COPDにおける呼吸音分布と肺機能の検討 (2014)
  • Author(s): 峯下昌道，木田博隆，古屋直樹，半田寛，西根広樹，石田敦子，延山誠一，井上健男，宮澤輝臣
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] Assessment of regional breath sound distribution and asynchrony using vibration response imaging in central airway obstruction before and after interventional bronchoscopy (2013)
  • Author(s): Masamichi Mineshita, Hirotaka Kida, Hiroshi Handa, Naoki Furuya, Hiroki Nishine, Seiichi Nobuyama, Takeo Inoue, Teruomi Miyazawa
  • Organizer: American Thoracic Society 2013
  • Place of Presentation: Philadelphia
• [Presentation] The effects of bronchodilators on regional lung sound distribution in patients with COPD (2013)
  • Author(s): Masamichi Mineshita, Mariko Okamoto, Ayane Tsukune, Teppei Inoue, Kei Morikawa, Naoki Furuya, Hiroshi Handa, Hirotaka Kida, Hiroki Nishine, Seiichi Nobuyama, Takeo Inoue, Shin Matsuoka,Teruomi Miyazawa
  • Organizer: European Respiratory Society 2013
  • Place of Presentation: Barcelona
• [Presentation] 中枢気道狭窄に対する気管支インターベンション前後における呼吸音分布のVibration Response Imaging (VRI) による評価 (2013)
  • Author(s): 峯下昌道、木田博隆、西根広樹、半田寛、井上健男、宮澤輝臣
  • Organizer: 第五回呼吸機能イメージング研究会
  • Place of Presentation: 徳島
• [Presentation] 気腫型COPDに対する気管支内一方向弁留置術と気管支喘息に対する気管支熱形成術 (2012)
  • Author(s): 峯下昌道
  • Organizer: 第52回日本呼吸器学会学術講演会
  • Place of Presentation: 神戸
• [Presentation] Vibration response imaging (VRI) in the diagnose and outcome assessments of interventional bronchoscopy in cases with central airway obstruction (2012)
  • Author(s): Masamichi Mineshita, Hiroki Nishine, Hiroshi Handa, Hirotaka Kida, Seiichi Nobuyama, Takeo Inoue, Teruomi Miyazaw
  • Organizer: 17th World Congress for Bronchology and Interventional Pulmonology
  • Place of Presentation: クリーブランド
• [Book] 気管支鏡ベストテクニック (2012)
  • Author(s): 浅野文祐、宮澤輝臣編
  • Total Pages: 247
  • Publisher: 中外医学社