| Project/Area Number |
24591157
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Niigata University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAGAMU Hiroshi 新潟大学, 医歯学系, 准教授 (30418686)
YOSHIZAWA Hirohisa 新潟大学, 医歯学総合病院, 特任教授 (50282984)
NAKATA Ko 新潟大学, 医歯学総合病院, 教授 (80207802)
MIURA Satoru 新潟大学, 医歯学総合病院, 特任助教 (70420320)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Tumor immunotherapy / Regulatory T cells / lung cancer / 腫瘍免疫 / 肺癌 / 抑制性T細胞 / 腫瘍免疫療法 / 細胞療法 / regulatory T cell / tumor immunotherapy / lymphodepletion / regulatory T cells |
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| Outline of Final Research Achievements |
It has been well established that priming of antitumor effector T cells is augmented during recovery from lymphopenia induced by cytotoxic regimens. We found immune-suppressive cells resistant to cytotoxic therapy were increased following cytotoxic regimens. Depletion of these immune-suppressive cells using monoclonal antibodies enhanced antitumor immune responses and delayed tumor progression.
Consistant with mice model, FACS analysis of peripheral blood monocytes from advanced small cell lung cancer patients revealed increased percentage of immune-suppressive cells after chemotehrarpy. Our results show that the combination of lymphodepletion with the further inhibition of immune-suppressive cells resistant to cytotoxic therapies represent a promising approach to enhance the efficacy of tumor immunotherapies.
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