| Project/Area Number |
24591161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TAKAFUMI Suda 浜松医科大学, 医学部, 教授 (30291397)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Yutaro 浜松医科大学, 医学部, 助教 (60436962)
NAGATA Toshi 浜松医科大学, 医学部, 教授 (90275024)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 肺炎球菌 / ワクチン / 樹状細胞 / クラススイッチ / クラス・スイッチ |
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| Outline of Final Research Achievements |
Theoretically, pneumococcal polysaccharide vaccine with 23 serotypes of capsular polysaccharide (PPV23) can induce only serotype-specific IgM antibody. In the present study, we showed that PPV23 readily induced both IgG- and IgA- serotype-specific antibodies through immunoglobulin class-switch recombination (CSR) in mouse and human. Next, we demonstrated that CD11b+ lung dendritic cells (DC), but not CD103+ lung DC, elicited T-cell independent CSR in the presence of toll-like receptor (TLR) ligands plus certain cytokines, such as IL-6 and IL-10. These results suggest that PPV23 induces protective serotype-specific IgG and IgA antibodies through an interaction of particular phenotypes of DC with IL-6 and IL-10.
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