Class-switching of immunoglobulins induced by pneumococcal vaccine
| Project/Area Number |
24591161
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TAKAFUMI Suda 浜松医科大学, 医学部, 教授 (30291397)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Yutaro 浜松医科大学, 医学部, 助教 (60436962)
NAGATA Toshi 浜松医科大学, 医学部, 教授 (90275024)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 肺炎球菌 / ワクチン / 樹状細胞 / クラススイッチ / クラス・スイッチ |
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| Outline of Final Research Achievements |
Theoretically, pneumococcal polysaccharide vaccine with 23 serotypes of capsular polysaccharide (PPV23) can induce only serotype-specific IgM antibody. In the present study, we showed that PPV23 readily induced both IgG- and IgA- serotype-specific antibodies through immunoglobulin class-switch recombination (CSR) in mouse and human. Next, we demonstrated that CD11b+ lung dendritic cells (DC), but not CD103+ lung DC, elicited T-cell independent CSR in the presence of toll-like receptor (TLR) ligands plus certain cytokines, such as IL-6 and IL-10. These results suggest that PPV23 induces protective serotype-specific IgG and IgA antibodies through an interaction of particular phenotypes of DC with IL-6 and IL-10.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Plasma connective tissue growth factor levels as potential biomarkers of airway obstruction in patients with asthma. Ann Allergy Asthma Immunol.2014
Author(s)
Kato M, Fujisawa T, Hashimoto D, Kono M, Enomoto N, Nakamura Y, Inui N, Hamada E, Miyazaki O, Kurashita S, Maekawa M, Suda T
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Journal Title
Ann Allergy Asthma Immunol.
Volume: 113 (3)
Issue: 3
Pages: 295-300
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] TLR-Mediated Airway IL-17C Enhances Epithelial Host Defense in an Autocrine/Paracrine Manner.2014
Author(s)
Kusagaya H, Fujisawa T*, Yamanaka K, Mori K, Hashimoto D, Enomoto N, Inui N, Nakamura Y, Wu R, Maekawa M, Suda T, Chida K.
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Journal Title
Am J Respir Cell Mol Biol.
Volume: 50
Issue: 1
Pages: 30-39
DOI
Related Report
Peer Reviewed
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[Presentation] Idiopathic Pleuroparenchymal Fibroelastosis (IPPFE): Comparison Of Clinico-Pathological Findings With Idiopathic Pulmonary Fibrosis (IPF)2013
Author(s)
Enomoto N, Kusagaya H, Oyama Y, Kono M, Hashimoto D, Fujisawa T, Nakamura Y, Inui N, Kaida Y, Kuroishi S, Yokomura K, Suda T, Chida K
Organizer
米国胸部疾患学会
Place of Presentation
Philadelphia
Related Report
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[Presentation] Pleuroparenchymal Fibroelastosis (IPPFE): Comparison Of Clinico-Pathological Findings With Idiopathic Pulmonary Fibrosis (IPF)2013
Author(s)
Enomoto N, Kusagaya H, Oyama Y, Kono M, Hashimoto D, Fujisawa T, Nakamura Y, Inui N, Kaida Y, Kuroishi S, Yokomura K, Suda T, Chida K
Organizer
米国胸部疾患学会
Place of Presentation
Philadelphia
Related Report
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