Studies on molecular basis of inhibitory effect of surfactant protein A against cytotoxicity of human b-defensin3.
| Project/Area Number |
24591173
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
ARIKI Shigeru 札幌医科大学, 医学部, 講師 (80464478)
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| Co-Investigator(Renkei-kenkyūsha) |
KUROKI Yoshio 札幌医科大学, 医学部, 教授 (70161784)
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| Research Collaborator |
UEHARA Yasuaki
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 自然免疫 / 抗菌ペプチド / 肺コレクチン / サーファクタントタンパク質 / 感染症 / 肺サーファクタントタンパク質 |
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| Outline of Final Research Achievements |
Antimicrobial peptides are host defense peptides with a broad spectrum of microbicidal activity. In this study, we suggested that combined use of hBD3 and SP-A-derived peptide (SAP01) is a candidate as a therapeutic reagent against infectious diseases. Binding of SAP01 to hBD3 attenuated cytotoxicity and excess inflammation induced by hBD3. Interestingly, SAP01 did not affect microbicidal activity at concentration sufficient for anti-cytotoxic activity. Because hBD3 also effectively kill drug-resistant microbes, there is appreciable interest in hBD3 for pharmaceutical applications.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Suppression of heregulin beta signaling by the single N-glycan deletion mutant of soluble ErbB3 protein.2013
Author(s)
Takahashi M, Hasegawa Y, Ikeda Y, Wada Y, Tajiri M, Ariki S, Takamiya R, Nishitani C, Araki M, Yamaguchi Y, Taniguchi N, Kuroki Y.
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Journal Title
J Biol Chem.
Volume: 288
Pages: 3291032921-3291032921
DOI
Related Report
Peer Reviewed
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