Pathogenesis of immune cells in progressive kidney disease
| Project/Area Number |
24591192
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Kidney internal medicine
|
|---|
| Research Institution | Kanazawa University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
WADA Takashi 金沢大学, 医学系, 教授 (40334784)
|
|---|
| Project Period (FY) |
2012-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 糖尿病性腎症 / 免疫担当細胞 / 慢性炎症 / 炎症性疾患 / 炎症・免疫 / 腎固有細胞 / 糖尿病 |
|---|
| Outline of Final Research Achievements |
High glucose (HG) stimulates various kinds of leukocytes, resulting in an abberant the inflammatory/anti-inflammatory immune balance. However, it is unclear if renal resident cells showed an abberant immune balance in diabetic nephropathy (DN). Therefore, we hypothesized that the aberrant immune balance of renal resident cells contributes to the pathogenesis of DN. To explore this possibility, we performed genome-wide transcriptome profiling in mesangial cells and tubular epithelial cells (TECs), which were stimulated by HG and detected the expression of inflammation associated genes. Pro-inflammatory/Th1 gene expression was upregulated, but Th2 related gene expression was downregulated in mesangial cells. In TECs, HG stimulation increased pro-inflammatory/Th1/Th2 gene expression. The data taken together indicate that HG shifts the immune balance toward pro-inflammatory/Th1 phenotype in renal resident cells, which might initiate and/or prolong inflammation.
|
Report
(4 results)
Research Products
(23 results)
-
[Journal Article] Pro-inflammatory/Th1 gene expression shift in high glucose stimulated mesangial cells and tubular epithelial cells.2014
Author(s)
Iwata Y, Furuichi K, Hashimoto S, Yokota K, Yasuda H, Sakai N, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Matsushima K, Kaneko S, Wada T.
-
Journal Title
Biochem Biophys Res Commun
Volume: 443
Issue: 3
Pages: 969-974
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
[Journal Article] Long-term outcomes of Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy.2013
Author(s)
Shimizu M, Furuichi K, Toyama T, Kitajima S, Hara A, Kitagawa K, Iwata Y, Sakai N, Takamura T, Yoshimura M, Yokoyama H, Kaneko S, Wada T and Kanazawa Study Group for Renal Diseases and Hypertension.
-
Journal Title
Diabetes Care
Volume: 36
Issue: 11
Pages: 3655-3662
DOI
Related Report
Peer Reviewed
-
[Journal Article] Successful delivery in a patient with antineutrophil cytoplasmic antibody-associated glomerulonephritis.2013
Author(s)
Oshima M, Kitajima S, Toyama T, Hara A, Kitagawa K, Iwata Y, Shimizu M, Nishio S, Imura J, Yokoyama H, Furuichi K, Kaneko S, Wada T.
-
Journal Title
Intern Med
Volume: 52
Pages: 1605-9
NAID
Related Report
Peer Reviewed
-
-
-
-
-
[Presentation] 炎症が妨げる再生2014
Author(s)
岩田恭宜、和田隆志
Organizer
第57回日本腎臓学会総会
Place of Presentation
パシフィコ横浜
Year and Date
2014-07-04 – 2014-07-06
Related Report
Invited
-
-
-
-
[Presentation] Genome-wide profiling of inflammation related genes in high glucose stimulated mesangial cells and tubular epithelial cells2013
Author(s)
Yasunori Iwata, Kengo Furuichi, Shinichi Hashimoto, Kiyotsugu Yokota, Haruka Yasuda, Norihiko Sakai, Shinji Kitajima, Tadashi Toyama, Yasuyuki Shinozaki, Akihiro Sagara, Kouji Matsushima , Shuichi Kaneko and Takashi Wada
Organizer
American sosiety of nephrilogy kidney week
Place of Presentation
Atlanta, USA
Related Report
-
-
-
-
-
-
[Book] 腎と透析2013
Author(s)
岩田 恭宜, 古市 賢吾, 北川 清樹, 横山 仁, 和田 隆志
Total Pages
4
Publisher
東京医学社
Related Report
-
-
-
