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Role of mitochondrial damage-associated molecule patterns on septic acute kidney injury

Research Project

Project/Area Number 24591194
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Kidney internal medicine
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

YASUDA Hideo  浜松医科大学, 医学部附属病院, 講師 (60432209)

Co-Investigator(Kenkyū-buntansha) TSUJI Takayuki  浜松医科大学, 医学部, 助教 (30464126)
KATO Akihiko  浜松医科大学, 医学部附属病院, 准教授 (60324357)
Project Period (FY) 2012-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords急性腎障害 / 敗血症 / 自然免疫 / ミトコンドリアDNA / TLR9
Outline of Final Research Achievements

The purpose of this study is to clarify whether 1) mitochondrial (mt) DNA is released during sepsis, 2)circulating mtDNA can induce acute kidney injury (AKI), and 3) the effects of mtDNA on kidney injury can be exerted via Toll-like Receptor (TLR) 9. Polymicrobial sepsis by peritonitis in mice early caused lots of circulating mtDNA followed by renal failure. Septic AKI was improved by TLR9 knockout (KO). Admiministration of mt debris including much mtDNA caused renal oxidative stress and mt injury, which was reduced by TLR9KO. Circulating mtDNA released during sepsis contributes to AKI via TLR9.

Report

(4 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • 2012 Research-status Report
  • Research Products

    (3 results)

All 2015 2014 Other

All Journal Article (1 results) Presentation (2 results)

  • [Journal Article] 敗血症性AKIの病態生理と臨床における課題2015

    • Author(s)
      安田日出夫、辻孝之、辻尚子、山本龍夫
    • Journal Title

      日本腎臓学会誌

      Volume: 57 Pages: 284-290

    • Related Report
      2014 Annual Research Report
  • [Presentation] ミトコンドリアDNAはTLR9を介して敗血症性急性腎障害に関与する2014

    • Author(s)
      辻 尚子、安田 日出夫、辻 孝之、大橋 温、加藤 明彦、藤垣 嘉秀
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      横浜
    • Year and Date
      2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] ミトコンドリアDNAはTLR9を介して敗血症性急性腎障害に関与する

    • Author(s)
      辻 尚子、安田日出夫、辻 孝之 、大橋 温、加藤明彦、藤垣嘉秀
    • Organizer
      第57回日本腎臓学会学術総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2013-05-31   Modified: 2019-07-29  

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