| Project/Area Number |
24591209
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Yokohama City University |
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Principal Investigator |
HASHIMOTO Tatsuo 横浜市立大学, 医学(系)研究科(研究院), 客員研究員 (20363806)
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| Research Collaborator |
UMEMURA Satoshi 横浜市立大学, 医学研究科, 教授
SUZUKI Syota 横浜市立大学, 大学院医学研究科
NAKAUCHI Hiromitsu 東京大学, 医科学研究所, 教授
YAMAGUCHI Tomoyuki 東京大学, 医科学研究所, 特任准教授
PENNINGER Josef オーストリア科学アカデミー, 分子生物工学研究所, 教授
NAKAZAWA Masatoshi 横浜市立大学, 医学部, 准教授
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 腎臓再生 / 国際情報交換 |
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| Outline of Final Research Achievements |
The aim of this study is to generate rat kidney in mouse by inter specific injection of stem cells, toward human kidney generation. At first, I injected mouse ES cells to generate mouse kidney.
First, I generated kidney deficient mouse. Second, I injected mouse ES cells into embryo. Kidney deficient embryo would be expected to exist 25 % under the Mendelian ratio. Rare mouse which has fully functioned kidney from injected cells can alive. An advice from coworker helped me to mix background. Then I can get more mice than before.
This study has possibility to generate brand new medical treatment towards human organ generation.
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