Research for investigation of pathogenesis of nephropathy in low-birth-weight individuals
| Project/Area Number |
24591222
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Kidney internal medicine
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| Research Institution | Clinical research Center, Chiba-East National Hospital, National Hospital Organization |
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Principal Investigator |
Imasawa Toshiyuki 独立行政法人国立病院機構(千葉東病院臨床研究部), その他部局等, その他 (80348276)
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| Research Collaborator |
TANAKA Masashi 東京都健康長寿医療センター, 健康長寿ゲノム探索研究チーム, リーダー
YAMAGUCHI Yutaka 前東京慈恵会医科大学, 柏病院病理学, 教授
Rossignol Rodrigue INSERM(U688 Physiopathologie Mitochondriale), Bordeaux Univ
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| Project Period (FY) |
2012-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | ミトコンドリア / 巣状分節状糸球体硬化症 / 低出生体重 / 糖尿病性腎症 / エネルギー代謝 / 糸球体上皮細胞 / Mitochondria |
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| Outline of Final Research Achievements |
The main results are;
1.Establishment of rat model of low-birth-weight related nephropathy, which resembles human low-birth-weight related nephropathy; 2.Elucidation of decreased mitochondrial function, for examples decreased OXPHOS complex subunits and decreased enzymes of TCA cycle, in kidneys in low-birth-weight rats mainly by proteome analysis; 3.Elucidation of well-developed mitochondrial networks in human podocytes (HPs) in vivo and in vitro; 4.Elucidation of processes and mechanism how HP develop their energy metabolic systems; 5.Elucidation of HPs change their energy metabolic system to glycolysis-dependent way in high glucose by using human podocyte cell line
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Report
(5 results)
Research Products
(8 results)
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[Journal Article] Hemodialysis patients born with a low birth weight should have a different time course of kidney diseases than those born with a normal birth weight.2013
Author(s)
Imasawa T(corresponding author), Fukuda N, Hirose S, Kato N, Shinya Suganuma5, Yamamoto R, Kimura H, Kadomura M, Nishimura M, Yoshimura M, Ikei S
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Journal Title
Ther Apher Dial
Volume: in press
Related Report
Peer Reviewed
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