The elucidation of the signalings of cytoskeletal reorganization involved in the development of HTLV-I-associated myelopathy
Project/Area Number |
24591267
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Neurology
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Research Institution | Nagasaki University |
Principal Investigator |
NAKAMURA Tatsufumi 長崎大学, 医歯薬学総合研究科(医学系), 客員研究員 (00198219)
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Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hideki 長崎大学, 病院(医学系), 講師 (10437832)
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Project Period (FY) |
2012-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2012: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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Keywords | HTLV-I関連脊髄症 / HTLV-I / 細胞内骨格再構成 / 細胞内シグナル伝達 / 細胞内シグナル伝達 |
Outline of Final Research Achievements |
We investigated the factors involved in the development of HTLV-I-associated Myelopathy(HAM)from the point of view of cytoskeletal reorganization using the efficiency of intercellular transmission of HTLV-I by co-cultivation with HTLV-I-infected T cell lines and H9/K30 luc reporter cells as an indicator. From our data, it was suggested as bellows: 1) activation of cytoskeletal reorganization by down-regulated intracellular cAMP level in HTLV-I-infected cells in HAM patients. 2) activation of CXCR4 signaling leading to Rap1 activation with activation of cytoskeleton reorganization involved in the heightened transmigrating activity to the tissues in HTLV-I-infected cells in HAM patients.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Pentosan polysulfate treatment ameliorates motor function with increased serum soluble vascular cell adhesion molecule-1 in HTLV-1 associated neurologic disease.2014
Author(s)
Nakamura T, Satoh K, Fukuda T, Kinoshita I, Nishiura Y, Nagasato K, Yamauchi A, Kataoka Y, Nakamura T, Sasaki H, Kumagai K, Niwa M, Noguchi M, Nakamura H, Nishida N, Kawakami A.
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Journal Title
J Neurovirol.
Volume: 20
Issue: 3
Pages: 269-277
DOI
Related Report
Peer Reviewed
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[Journal Article] Efficacy of prosultiamine treatment in patients with HTLV-I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial.2013
Author(s)
Nakamura T, Matsuo T, Fukuda T, Yamato S, Yamaguchi K, Kinoshita I, Matsuzaki T, Nishiura Y, Nagasato K, Narita-Masuda T, Nakamura H, Satoh K, Sasaki H, Sakai H, Kawakami A.
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Journal Title
BMC Med
Volume: 11
Issue: 1
Pages: 182-182
DOI
Related Report
Peer Reviewed
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