Establishment of a diagnosis of hereditary prion disease and the development of new classification and analysis
| Project/Area Number |
24591268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Nagasaki University |
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Principal Investigator |
SATOH Katsuya 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (70398147)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | プリオン病 / 遺伝性 / 遺伝性プリオン病 / 臨床症状 / 髄液検査 / 髄液 |
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| Outline of Final Research Achievements |
We succeed to amplify a very small amount of abnormal prion protein in in vitro as an epoch-making method of CSF as a diagnostic stool in human prion disease and reported the Real-time QUIC method and got a high evaluation. I collected CSF samples in cooperation with prion disease surveillance Committee.
I analyzed the specimen of all country prion disease cases using the RT-QUIC method which we developed and elevated on biochemical markers which I reported conventionally and aimed at the establishment of the diagnostic method of genetic prion disease and was able to succeed. Furthermore, I aimed at the development of a new therrpy for genetic prion disease disease and discovered the drug that it was with a therapeutic drug candidate now. I am screening it.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Clinical features of genetic Creutzfeldt-Jakob disease with V180I mutation in the prion protein gene.2014
Author(s)
Qina, T., N. Sanjo, M. Hizume, M. Higuma, M. Tomita, R. Atarashi, K. Satoh, I. Nozaki, T. Hamaguchi, Y. Nakamura, A. Kobayashi, T. Kitamoto, S. Murayama, H. Murai, M. Yamada and H. Mizusawa
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Journal Title
BMJ Open
Volume: 4
Issue: 5
Pages: e004968-e004968
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Relationships between clinicopathological features and cerebrospinal fluid biomarkers in Japanese patients with genetic prion diseases.2013
Author(s)
Higuma M, Sanjo N, Satoh K, Shiga Y, Sakai K, Nozaki I, Hamaguchi T, Nakamura Y, Kitamoto T, Shirabe S, Murayama S, Yamada M, Tateishi J, Mizusawa H.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice.2013
Author(s)
Nakagaki T, Satoh K, Ishibashi D, Fuse T, Sano K, Kamatari YO, Kuwata K, Shigematsu K, Iwamaru Y, Takenouchi T, Kitani H, Nishida N, Atarashi R.
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Journal Title
Autophagy
Volume: 9(9)
Pages: 1386-1394
Related Report
Peer Reviewed
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[Journal Article] Efficacy of prosultiamine treatment in patients with human T lymphotropic virus type I-associated myelopathy/tropical spastic paraparesis: results from an open-label clinical trial.2013
Author(s)
Nakamura T, Matsuo T, Fukuda T, Yamato S, Yamaguchi K, Kinoshita I, Matsuzaki T, Nishiura Y, Nagasato K, Narita-Masuda T, Nakamura H, Satoh K, Sasaki H, Sakai H, Kawakami A
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Journal Title
BMC Med
Volume: １１
Pages: 182-182
Related Report
Peer Reviewed
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[Journal Article] Early Detection of Abnormal Prion Protein in Genetic Human Prion Diseases Now Possible Using Real-Time QUIC Assay.2013
Author(s)
Sano K, Satoh K, Atarashi R, Takashima H, Iwasaki Y, Yoshida M, Sanjo N, Murai H, Mizuswawa H, Schmitz M, Zerr I, Kim Y, Nishida N
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Rapidly progressive Alzheimer's disease: a multicenter update.2012
Author(s)
Schmidt C, Haïk S, Satoh K, Rábano A, Martinez-Martin P, Roeber S, Brandel JP, Calero-Lara M, de Pedro-Cuesta J, Laplanche JL, Hauw JJ, Kretzschmar H, Zerr I.
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Journal Title
J Alzheimers Dis
Volume: 30(4)
Pages: 751-756
Related Report
Peer Reviewed
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