Development of novel diagnostic methods for Parkinson's disease.

Research Project

Project/Area Number	24591297
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Neurology
Research Institution	Kagawa University
Principal Investigator	DEGUCHI Kazushi 香川大学, 医学部, 准教授 (80263896)
Co-Investigator(Kenkyū-buntansha)	IKEDA Kazuyo 香川大学, 医学部, 助教 (30592315) KARAKI Masayuki 香川大学, 医学部附属病院, 講師 (50294757) TOUGE Tetsuo 香川大学, 医学部, 教授 (80197839)
Project Period (FY)	2012-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords	パーキンソン病 / 多系統萎縮症 / 電流知覚閾値 / 感覚障害 / 近赤外線分光法 / 嗅覚
Outline of Final Research Achievements	We assessed current perception threshold (CPT) and near infrared spectroscopy (NIRS)as novel diagnostic methods for Parkinson's disease (PD).PD patients had significantly higher CPT than healthy controls and multiple system atrophy (MSA) patients.At the optimum cut-off level, the CPT at 5Hz (corresponding to C fibers) distinguished PD patients from healthy controls and MSA patients with a high sensitivity and specificity. NIRS showed only slightly-increased oxyhemoglobin and total hemoglobin after odor stimulation even in PD patients with normal sense of smell.These findings suggest that CPT at 5Hz and NIRS after odor stimulation have potential for useful diagnostic tools for PD.