The role of innate immunity in the pathogenesis of fulminant type 1 diabetes.
| Project/Area Number |
24591321
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | University of Yamanashi |
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Principal Investigator |
AIDA Kaoru 山梨大学, 総合研究部, 准教授 (50184015)
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| Co-Investigator(Kenkyū-buntansha) |
KOBAYASHI Tetsuro 公益財団法人冲中記念成人病研究所, 研究室, 研究員 (30113442)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 劇症１型糖尿病 / 自然免疫 / ウイルス感染 / エンテロウイルス / 劇症1型糖尿病 / エンテロウィルス / ヘルペスウィルス / インターフェロンα / インターフェロンγ / プロテオミクス / ヘルペスウイルス |
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| Outline of Final Research Achievements |
We showed the presence of enterovirus proteins in the patients pancreas from the fulminant type 1 diabetes (FT1D). In this project, Proteins expressed in the islets of enterovirus-associated fulminant type 1 diabetes (FT1DM) with extensive insulitis were identified by laser-capture microdissection mass spectrometry using formalin-fixed paraffin-embedded pancreatic tissues. The cellular localization of selected proteins was validated immunohistochemically. Thirty-eight proteins were identified solely in FT1DM islets, most of which have not been previously linked to type 1 diabetes. Those are proteins involved in successive signaling in innate/adaptive immunity, migratory activity-related proteins and proteins related to virus replication and cell proliferation. The identified FT1DM-characterizing proteins include those involved in aggressive beta cell destruction
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Diagnostic criteria for acute-onset type 1 diabetes mellitus (2012): Report of the Committee of Japan Diabetes Society on the Research of Fulminant and Acute-onset Type 1 Diabetes Mellitus.2014
Author(s)
Kawasaki E, Maruyama T, Imagawa A, Awata T, Ikegami H, Uchigata Y, Osawa H, Kawabata Y, Kobayashi T, Shimada A, Shimizu I, Takahashi K, Nagata M, Makino H, Hanafusa T.
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Journal Title
J Diabetes Investig
Volume: 12;5(1)
Pages: 115-8
NAID
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[Journal Article] Distinct cell clusters touching islet cells induce islet cell replication in association with over-expression of Regenerating Gene (REG) protein in fulminant type 1 diabetes.2014
Author(s)
Aida K, Saitoh S, Nishida Y, Yokota S, Ohno S, Mao X, Akiyama D, Tanaka S, Awata T, Shimada A, Oikawa Y, Shimura H, Furuya F, Takizawa S, Ichijo M, Ichijo S, Itakura J, Fujii H, Hashiguchi A, Takasawa S, Endo T, Kobayashi T.
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[Journal Article] 日本先進糖尿病治療研究会によるCSIIおよびCGMに関するステートメント2014
Author(s)
小林 哲郎, 難波 光義, 黒田 暁生, 松久 宗英, 山田 研太郎, 今村 洋一, 金重 勝博, 浜口 朋也, 川村 智行, 佐藤 譲, 高橋 和眞, 丸山 太郎, 西村 理明, 勝野 朋幸, 楠 宜樹, 清水 一紀, 柳澤 克之, 粟田 卓也, 雨宮 伸, 日本先進糖尿病治療研究会
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Journal Title
糖尿病
Volume: 57巻6号
Pages: 403-415
NAID
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[Presentation] 日本人1型糖尿病の包括的データベースの構築と臨床研究への展開(TIDE-J)(第2報)2014
Author(s)
梶尾 裕, 中條 大輔, 安田 和基, 春日 雅人, 花房 俊昭, 今川 彰久, 池上 博司, 大澤 春彦, 川崎 英二, 粟田 卓也, 高橋 和眞, 小林 哲郎, 島田 朗, 安田 尚史
Organizer
第57回日本糖尿病学会年次学術集会
Place of Presentation
大阪
Year and Date
2014-05-22 – 2014-05-24
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