Elucidation of the mechanism of pancreatic beta-cell differentiation and regeneration using inducible cell labeling system
Project/Area Number |
24591330
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Metabolomics
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Research Institution | Kobe University |
Principal Investigator |
MIANMI KOHTARO 神戸大学, 医学(系)研究科(研究院), 准教授 (80334176)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 糖尿病 / 糖代謝異常 / 膵β細胞 / 再生医療 |
Outline of Final Research Achievements |
In the present study, we chased the fate of pancreatic beta cells by utilizing inducible cell labeling system. In alloxan-induced diabetic mice, the human GLP-1 receptor agonist liraglutide restored function and mass of beta cells. Liraglutide increased beta cell proliferation and decreased beta cell death, but did not induce neogenesis of beta cells.
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Report
(4 results)
Research Products
(34 results)
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[Journal Article] Glutamate acts as a key signal linking glucose metabolism to incretin/cAMP action to amplify insulin secretion2014
Author(s)
Gheni G, Ogura M, Iwasaki M, Yokoi N, Minami K, Nakayama Y, Harada K, Hastoy B, Wu X, Takahashi H, Kimura K, Matsubara T, Hoshikawa R, Hatano N, Sugawara K, Shibasaki T, Inagaki N, Bamba T, Mizoguchi A, Fukusaki E, Rorsman P, Seino S
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Journal Title
Cell Rep
Volume: 9
Issue: 2
Pages: 661-673
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Conditional hypovascularization and hypoxia in islets does not overtly influence adult beta cell mass and function.2013
Author(s)
D’Hoker J, De Leu N, Heremans Y, Baeyens L, Minami K, Ying C, Lavens A, Chintinne M, Stange G, Magenheim J, Swisa A, Martens G, Pipeleers D, van de Casteele M, Seino S, Keshet E, Dor Y, Himberg H
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Journal Title
Diabetes
Volume: 62
Issue: 12
Pages: 4165-4173
DOI
Related Report
Peer Reviewed
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