| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
(1)Studies using beta Klotho knockout mice (KO) and hepatocyte-specific transgenic mice have shown that liver beta Klotho is both necessary and sufficient for lipid and lipoprotein homeostasis as well as for bile acid regulation. (2)Decreased body weight and resistance to diet-induced obesity in KO were not rescued by liver or adipocyte rescue of beta Klotho expression, suggesting that body weight regulation by beta Klotho is attributable to its expression in tissues other than these cells. (3)Amino acid dysregulation was found in KO mice, which was rescued by an adipocyte-specific rescue of beta Klotho expression.
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