A novel regulatory machinery for the digestion, absorption and accumulation of dietary lipids
| Project/Area Number |
24591355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Kyoto University |
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Principal Investigator |
TANAKA Tomohiro 京都大学, 医学(系)研究科(研究院), 准教授 (20402894)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 脂質 / シグナル伝達 / プロテオーム |
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| Outline of Final Research Achievements |
(1)Studies using beta Klotho knockout mice (KO) and hepatocyte-specific transgenic mice have shown that liver beta Klotho is both necessary and sufficient for lipid and lipoprotein homeostasis as well as for bile acid regulation. (2)Decreased body weight and resistance to diet-induced obesity in KO were not rescued by liver or adipocyte rescue of beta Klotho expression, suggesting that body weight regulation by beta Klotho is attributable to its expression in tissues other than these cells. (3)Amino acid dysregulation was found in KO mice, which was rescued by an adipocyte-specific rescue of beta Klotho expression.
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Report
(4 results)
Research Products
(46 results)
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[Journal Article] Reduced renal α-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism.2014
Author(s)
Sakan H, Nakatani K, Asai O, Imura A, Tanaka T, Yoshimoto S, Iwamoto N, Kurumatani N, Iwano M, Nabeshima Y, Konishi N, Saito Y.
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Journal Title
PLoS One.
Volume: 9(1):e86301
Issue: 1
Pages: 1-1
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Decreased renalα-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion2012
Author(s)
Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, Samejima K, Yamaguchi Y, Matsui M, Akai Y, Konishi N, Iwano M, Nabeshima Y, Saito Y
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Journal Title
Kidney Int
Volume: 81(6)
Issue: 6
Pages: 539-47
DOI
Related Report
Peer Reviewed
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