Development of trifunctional antibodies in multiple myeloma
| Project/Area Number |
24591402
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
YASUI Hiroshi 東京大学, 医科学研究所, 特任講師 (40448593)
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| Co-Investigator(Kenkyū-buntansha) |
ISHIDA Tadao 札幌医科大学, 医学部, 准教授 (20305220)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 多発性骨髄腫 / 抗体医薬 / 橋渡し研究 / 三重特異性抗体 / がん免疫療法 / 改変抗体 / 免疫細胞 |
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| Outline of Final Research Achievements |
The trifunctional antibody can bind specifically to tumor antigens and the T-cell antigen CD3 via each of the Fab-fragments as well as to macrophages via its Fc-fragment. We have developed a trifunctional antibody, which binds to CD3 and antigen A expressed on the surface of multiple myeloma cells. Such binding results in antibody-dependent cell-mediated cytotoxicity against myeloma cells as well as antitumor activity in human myeloma mouse model. We plan on acquiring the intellectual property rights as well as the university-industry research collaboration in order to put this finding to the practical use as an anti-myeloma drug.
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Report
(4 results)
Research Products
(29 results)
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[Journal Article] High Level of Serum Soluble Interleukin-2 Receptor at Transplantation Predicts Poor Outcome of Allogeneic Stem Cell Transplantation for Adult T Cell Leukemia.2014
Author(s)
Shigematsu A, Kobayashi N, Yasui H, Shindo M, Kakinoki Y, Koda K, Iyama S, Kuroda H, Tsutsumi Y, Imamura M, Teshima T.
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Journal Title
Biol Blood Marrow Transplant
Volume: －
Issue: 6
Pages: 801-805
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Epstein-Barr virus-infected cells in IgG4-related lymphadenopathy with comparison to extranodal IgG4-related disease2014
Author(s)
Takeuchi M, Sato Y, Yasui H, Ozawa H, Ohno K, Takata K, Iwaki N, Orita Y, Asano N, Nakamura S, Swerdlow SH, Yoshino T
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Journal Title
Am J Surg Pathol
Volume: 38
Pages: 946-955
Related Report
Peer Reviewed
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[Journal Article] Long-term survey of survival time, histological transformation, and secondary malignancies in Japanese patients with advanced-stage follicular lymphoma in the rituximab era: Hokkaido Hematology Study Group2014
Author(s)
Hirayama Y, Ishitani K, Ota S, Kurosawa M, Kondo T, Takimoto R, Mori A, Sakai H, Torimoto Y, Yamamoto S, Sato K, Iwasaki H, Kohda K, Ishida T, Kakinoki Y, Fukuhara T, Kato J
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Journal Title
Int J Hematol
Volume: 100
Issue: 3
Pages: 281-289
DOI
Related Report
Peer Reviewed
-
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[Journal Article] Epstein-Barr Virus-infected Cells in IgG4-related Lymphadenopathy With Comparison With Extranodal IgG4-related Disease.2014
Author(s)
Takeuchi M, Sato Y, Yasui H, Ozawa H, Ohno K, Takata K, Gion Y, Orita Y, Tachibana T, Itoh T, Asano N, Nakamura S, Swerdlow SH, Yoshino T.
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Journal Title
Am J Surg Pathol.
Volume: －
Issue: 7
Pages: 946-955
DOI
Related Report
Peer Reviewed
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[Journal Article] Coadministration of tenofovir decreased atazanavir plasma concentration after unilateral nephrectomy.2013
Author(s)
Kunimoto Y, Yasui H, Touda N, Okazaki M, Nakata H, Noda N, Ikeda H, Hayashi T, Takahashi S, Shinomura Y, Ishida T, Miyamoto A.
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Journal Title
J Infect Chemother.
Volume: 19
Issue: 4
Pages: 750-3
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Genomic vulnerability to LINE-1 hypermethylation is a potential determinant of the clinicogenetic features of multiple myeloma.2012
Author(s)
Aoki Y, Nojima M, Suzuki H, Yasui H, Maruyama R, Yamamoto E, Ashida M, Itagaki M, Asaoku H, Ikeda H, Hayashi T, Imai K, Mori M, Tokino T, Ishida T, Toyota M, Shinomura Y
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Journal Title
Genome Medicine
Volume: (印刷中)
Issue: 12
Pages: 101-101
DOI
Related Report
Peer Reviewed
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