Cell targeting therapy for acute myeloid leukemia
Project/Area Number |
24591403
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Hematology
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Research Institution | Sapporo Medical University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
KATO Junji 札幌医科大学, 医学部, 教授 (20244345)
KOBUNE Masayoshi 札幌医科大学, 医学部, 准教授 (90336389)
|
Project Period (FY) |
2012-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2014: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
|
Keywords | AML / fucose / DDS / 白血病 / 細胞標的療法 / 急性骨髄性白血病 / ナノキャリア / フコース |
Outline of Final Research Achievements |
Acute myelogenous leukemia (AML) will achieve complete remission by induction therapy due to improvements in supportive and optimization therapy. In order to improve treatment efficacy by anti cancer drugs, specificity of drugs to leukemic cells should be important to ameliorate prognosis, since maximum dose of chemotherapeutic agents might be administered to AML patients, expecting less toxicity and more efficacy. We targeted AML cells utilizing fucose-bound liposome, since we found AML cells actively uptake L-fucose. Herein we report that intravenously injected L-fucose-bound liposomes containing daunorubicin can be successfully delivered to AML cells. This resulted in efficient tumor growth inhibition as well as prolonged survival in tumor-bearing mice. Thus, biological targeting utilizing characteristics of AML cells by fucose-bound liposome could be a promising new strategy for AML treatment.
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Report
(4 results)
Research Products
(10 results)
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[Journal Article] RNAi-mediated gene silencing of ST6GalNAc I suppresses the metastatic potential in gastric cancer cells2014
Author(s)
Tamura F, Sato Y, Hirakawa M, Yoshida M, Ono M, Osuga T, Okagawa Y, Uemura N, Arihara Y, Murase K, Kawano Y, Iyama S, Takada K, Hayashi T, Sato T, Miyanishi K, Kobune M, Takimoto R, Kato J.
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Journal Title
Gastric Cancer
Volume: 23
Issue: 1
Pages: 85-97
DOI
NAID
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] A novel strategy inducing autophagic cell death in Burkitt’s lymphoma cells with anti-CD19-targeted liposomal rapamycin.2014
Author(s)
Ono K, Sato T, Iyama S, Tatekoshi A, Hashimoto A, Kamihara Y, Horiguchi H, Kikuchi S, Kawano Y,Takada K, Hayashi T, Miyanishi K, Sato Y, Takimoto R, Kobune M, Kato J.
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Journal Title
Blood Cancer J
Volume: 7
Issue: 2
Pages: e180-e180
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Fucosylated TGF-ß receptors transduces a signal for epithelial-mesenchymal transition in colorectal cancer cells.2014
Author(s)
Hirakawa M, Takimoto R, Tamura F, Yoshida M, Ono M, Murase K, Sato Y, Osuga T, Sato T, Iyama S, Miyanishi K, Takada K, Hayashi T, Kobune M, Kato J.
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Journal Title
Br J Cancer
Volume: 110
Issue: 1
Pages: 156-163
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes.2013
Author(s)
Ishiwatari H, Sato Y, Murase K, Yoneda A, Fujita R, Nishita H, Birukawa NK, Hayashi T, Sato T, Miyanishi K, Takimoto R, Kobune M, Ota S, Kimura Y, Hirata K, Kato J, Niitsu Y.
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Journal Title
Gut
Volume: 62(9)
Issue: 9
Pages: 1328-39
DOI
Related Report
Peer Reviewed
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[Journal Article] Treatment of pancreatic fibrosis with siRNA against a collagen-specific chaperone in vitamin A-coupled liposomes.2012
Author(s)
Ishiwatari H, Sato Y, Murase K, Yoneda A, Fujita R, Nishita H, Birukawa NK, Hayashi T, Sato T, Miyanishi K, Takimoto R, Kato J, Niitsu Y.
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach.2012
Author(s)
Yoshida M, Takimoto R, Murase K, Sato Y, Hirakawa M, Tamura F, Sato T, Iyama S, Osuga T, Miyanishi K, Takada K, Hayashi T, Kobune M, Kato J.
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Journal Title
PLoS One
Volume: 7(7)
Issue: 7
Pages: e39545-e39545
DOI
Related Report
Peer Reviewed
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