| Project/Area Number |
24591407
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
TAKI Tomohiko 京都府立医科大学, 医学(系)研究科(研究院), 講師 (50322053)
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| Co-Investigator(Kenkyū-buntansha) |
KAWAMURA Machiko 公益財団法人東京都医学研究所, 研究員 (80450592)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | がん / ゲノム / キメラ遺伝子 / 非コード遺伝子 / リボゾーム遺伝子 / PVT1 / NSMCE2 / RNAシーケンス / RN28S1 / BCL11B / IGK / COG1 / キメラ転写産物 |
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| Outline of Final Research Achievements |
Noncoding gene, PVT1 was frequently rearranged in multiple myeloma, and the PVT1-WWOX was identified in RPMI8226 cell line. We further identified another fusion transcript of PVT1, PVT1-NSMCE2, in acute myeloid leukemia (AML) having highly genomic amplification with 8q24. Novel fusion partner of PVT1, NSMCE2, also created BF104016-NSMCE2 fusion transcript in an AML cell line. On the other hand, we identified another type of fusion transcript involving ribosomal DNA. Three fusion transcripts involving RN28S1 were identified in T-cell acute lymphoblastic leukemia, Burkitt lymphoma, and multiple myeloma, respectively. Further analysis is needed to clarify the role of these novel types of fusion transcript in tumorigenesis.
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