| Project/Area Number |
24591451
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Nagasaki University |
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Principal Investigator |
TAMAI Mami 長崎大学, 医歯薬学総合研究科(医学系), 講師 (60380862)
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| Co-Investigator(Kenkyū-buntansha) |
ARIMA Kazuhiko 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30423635)
UETANI Masataka 長崎大学, 医歯薬学総合研究科(医学系) (40176582)
OHYAMA Kaname 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (50437860)
AOYAGI Kiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80295071)
KAWAKAMI Atsushi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90325639)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 関節リウマチ / MRI骨髄浮腫 / 診断 / X線進行予測 / MRI / 骨炎 / MRI骨炎 / 治療 / 重症化予測 |
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| Outline of Final Research Achievements |
The aim of this study is to examine the utility of MRI findings, especially bone edema, in patients with early-stage RA from Nagasaki University Early Arthritis Cohort. First, we found that MRI bone edema could improve the diagnostic performance of 2010 RA classification criteria (sensitivity 62 to 76% and accuracy 70 to 76%) in 166 early RA whose duration within 6 months (median 2 months). Second, we found that MRI bone edema at baseline could predict the development of rapid radiographic progression (RRP) (Odds ratio 2.18) in 76 early RA patients (median duration 3 months, RRP 15%, RF 79%, ACPA 82%). In addition, MRI bone erosion involved in poor radiographic outcome in early-stage RA patients even successfully treated by T2T strategy (Odds ratio 3.00) in the same 76 patients.
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