The examination of utility of MRI bone edema in early rheumatoid arthritis

• Project/Area Number: 24591451
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Nagasaki University
• Principal Investigator: TAMAI Mami 長崎大学, 医歯薬学総合研究科(医学系), 講師 (60380862)
• Co-Investigator(Kenkyū-buntansha): ARIMA Kazuhiko 長崎大学, 医歯薬学総合研究科(医学系), 講師 (30423635) ; UETANI Masataka 長崎大学, 医歯薬学総合研究科(医学系) (40176582) ; OHYAMA Kaname 長崎大学, 医歯薬学総合研究科(医学系), 准教授 (50437860) ; AOYAGI Kiyoshi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (80295071) ; KAWAKAMI Atsushi 長崎大学, 医歯薬学総合研究科(医学系), 教授 (90325639)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 関節リウマチ / MRI骨髄浮腫 / 診断 / X線進行予測 / MRI / 骨炎 / MRI骨炎 / 治療 / 重症化予測

Outline of Final Research Achievements

The aim of this study is to examine the utility of MRI findings, especially bone edema, in patients with early-stage RA from Nagasaki University Early Arthritis Cohort. First, we found that MRI bone edema could improve the diagnostic performance of 2010 RA classification criteria (sensitivity 62 to 76% and accuracy 70 to 76%) in 166 early RA whose duration within 6 months (median 2 months). Second, we found that MRI bone edema at baseline could predict the development of rapid radiographic progression (RRP) (Odds ratio 2.18) in 76 early RA patients (median duration 3 months, RRP 15%, RF 79%, ACPA 82%). In addition, MRI bone erosion involved in poor radiographic outcome in early-stage RA patients even successfully treated by T2T strategy (Odds ratio 3.00) in the same 76 patients.

Research Products

• [Journal Article] Response to: 'Does adding the presence of MRI detected bone marrow oedema improve the accuracy of the 2010 EULAR/ACR criteria for rheumatoid arthritis?' by Nieuwenhuis et al. (2015)
  • Author(s): Tamai M, Kawakami A
  • Journal Title: Annals of Rheumatic Diseases Volume: 74 Issue: 3 Pages: e30-e30
  • DOI: 10.1136/annrheumdis-2014-206936
  • Peer Reviewed / Open Access
• [Journal Article] Combination of MRI-detcted bone marrow oedema with 2010 rheumatoid arthritis classification criteria improves the diagnostic probability early rheumatoid arthritis. (2014)
  • Author(s): Tamai M, Kita J, Nakashima Y, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Arima K, Yama-saki S, Nakamura H, Origuchi T, Uetani M,Fukushima A, Aoyagi K, Kawakami A.
  • Journal Title: Annals of Rheumatic Diseases Volume: 73 Issue: 12 Pages: 2219-20
  • DOI: 10.1136/annrheumdis-2013-205074
  • Peer Reviewed / Open Access
• [Journal Article] Significant improvement in MRI-proven bone edema is associated with protection from structural damage in very early RA patients managed using the tight control approach. (2012)
  • Author(s): Kita J, Tamai M, Arima K, Kawashiri SY, Horai Y, Iwamoto N, Okada A, Koga T, Nakashima Y, Suzuki T, Yamasaki S, Nakamura H, Origuchi T, Ida H, Aoyagi K, Uetani M, Eguchi K, Kawakami A
  • Journal Title: Mod Rheumatol Volume: 23 Issue: 2 Pages: 254-259
  • DOI: 10.1007/s10165-012-0646-5
  • NAID: 10031167696
  • Peer Reviewed
• [Journal Article] RA新分類基準の検証：Leiden早期関節炎コホートによる2010年RA新分類基準の検証 (2012)
  • Author(s): 玉井慎美
  • Journal Title: Frontiers in Rheumatology & Clinical Immunology Volume: 21 Pages: 32-35
• [Journal Article] 分類不能関節炎におけるMRI骨髄浮腫の意義 (2012)
  • Author(s): 玉井慎美
  • Journal Title: リウマチ科 Volume: 1 Pages: 119-124
• [Presentation] 長崎大学早期関節炎コホートからのメッセージ (2014)
  • Author(s): 玉井慎美、中島好一、喜多潤子、有馬和彦、川尻真也、岩本直樹、中村英樹、折口智樹、上谷雅孝、青柳潔、江口勝美、川上純
  • Organizer: 第29回日本臨床リウマチ学会
  • Place of Presentation: 福岡国際会議場（福岡市）
  • Year and Date: 2014-11-29
• [Presentation] MRI osteitis at baseline predicts the development of rapid radio- graphic progression at 1 year toward patients with early-stage rheumatoid arthritis: Results from Nagasaki University Early Arthritis Cohort (2014)
  • Author(s): Nakashima Y, Tamai M, Kita J, Tsuji S, Fukui S, Umeda M, Nishino A, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S, Iwamoto N, Ichinose K, Hirai Y, Arima K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Eguchi K, Kawakami A.
  • Organizer: American College of Rheumatology
  • Place of Presentation: Boston Convention & Exhibition Center（Boston, USA）
  • Year and Date: 2014-11-17
• [Presentation] Investigation of MRI bone changes in early-stage RA patients achieved in sustained clinical good response: Sub-analysis from Nagasaki University Early Arthritis Cohort (2014)
  • Author(s): Tamai M, Arima K, Nakashima Y, Umeda M, Fukui S, Nishino A, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri S-Y, Iwamoto N, Ichi-nose K, Nakamura H, Origuchi T, Uetani M, Aoyagi K, Kawakami A.
  • Organizer: American College of Rheumatology
  • Place of Presentation: Boston Convention & Exhibition Center（Boston, USA）
  • Year and Date: 2014-11-16
• [Presentation] 関節リウマチ治療経過におけるMRI骨炎減少率とX線進行 (2014)
  • Author(s): 玉井慎美、上谷雅孝、中島好一、梅田雅孝、福井翔一、西野文子、川尻真也、古賀智裕、岩本直樹、一瀬邦弘、有馬和彦、中村英樹、折口智樹、青柳潔、川上純
  • Organizer: 第42回日本臨床免疫学会総会
  • Place of Presentation: 京王プラザホテル（新宿区）
  • Year and Date: 2014-09-25
• [Presentation] 関節MRI骨炎は2010年分類基準を用いた早期RA診断能を向上させる：長崎早期関節炎コホートを用いた解析 (2014)
  • Author(s): 玉井慎美、喜多潤子、中島好一、鈴木貴久、寶来吉朗、岡田覚丈、古賀智裕、川尻真也、岩本直樹、一瀬邦弘、有馬和彦、中村英樹、折口智樹、上谷雅孝、青柳潔、江口勝美、川上純
  • Organizer: 第58回日本リウマチ学会総会
  • Place of Presentation: プリンスホテル新高輪（品川区）
  • Year and Date: 2014-04-26
• [Presentation] 強化治療による早期関節リウマチの臨床的疾患活動性とX線予後の改善 (2014)
  • Author(s): 玉井慎美、中島好一、喜多潤子、有馬和彦、川尻真也、中村英樹、上谷雅孝、青柳潔、江口勝美、川上純
  • Organizer: 第111回日本内科学会総会
  • Place of Presentation: 東京国際フォーラム（千代田区）
  • Year and Date: 2014-04-11
• [Presentation] Magnetic resonance imaging-proven osteitis at baseline predicts the early RA patients who will develop rapid radiographic progression: MRI is beneficial to find the window of opportunity in early RA
  • Author(s): Mami Tamai, Yoshikazu Nakashima, Takahisa Suzuki, Yoshiroh Horai, Akitomo Okada, Junko Kita, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Kazuhiko Arima, Hideki Nakamura, Masataka Uetani, Tomoki Origuchi, Kiyoshi Aoyagi, Katsumi Eguchi , Atsushi Kawakami
  • Organizer: 第57回日本リウマチ学会
  • Place of Presentation: 京都国際会館（京都市左京区）
• [Presentation] Stringent therapies improve both radiographic and clinical outcome in early-stage RA patients from Japanese population: Longitudinal study from Nagasaki Early Arthritis Cohort
  • Author(s): Mami Tamai, Yoshikazu Nakashima, Takahisa Suzuki, Junko Kita, Yoshiro Horai, Akitomo Okada, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Kazuhiko Arima, Hideki Nakamura, Tomoki Origuchi, Masataka Uetani, Kiyoshi Aoyagi, Katsumi Eguchi, Atsushi Kawakami
  • Organizer: European League Against Rheumatism 2013
  • Place of Presentation: Feria de Madrid（スペイン、マドリッド）
• [Presentation] Stringent therapies improve clinical, radiographic and magnetic resonance imaging outcome in early-stage rheumatoid arthritis patients from Japanese population: Longitudinal study from Nagasaki Early Arthritis Cohort
  • Author(s): Mami Tamai, Yoshikazu Nakashima, Junko Kita, Ayuko Takatani, Ayako Nishino, Takahisa Suzuki, Yoshiro Horai, Akitomo Okada, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Kazuhiko Arima, Hideki Nakamura, Tomoki Origuchi, Masataka Uetani, Kiyoshi Aoyagi, Katsumi Eguchi, Atsushi Kawakami
  • Organizer: American College of Rheumatology 2013
  • Place of Presentation: San Diego Convention Center（USA、カリフォルニア州、サンディエゴ）
• [Presentation] Combination of MRI-proven osteitis with 2010 RA classification criteria improves the diagnostic probability of early RA whose disease duration less than 6 months
  • Author(s): Mami Tamai, Junko Kita, Yoshikazu Nakashima, Takahisa Suzuki, Yoshiro Horai, Akitomo Okada, Tomohiro Koga, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Kazuhiko Arima, Satoshi Yamasaki, Hideki Nakamura, Tomoki Origuchi, Masataka Uetani, Aya Fukushima, Kiyoshi Aoyagi, Katsumi Eguchi, Atsushi Kawakami
  • Organizer: American College of Rheumatology 2013
  • Place of Presentation: San Diego Convention Center（USA、カリフォルニア州、サンディエゴ）
• [Presentation] 抗CCP抗体価とMRI骨炎：RAにおける関節破壊
  • Author(s): 玉井慎美
  • Organizer: 第109回日本内科学会総会
  • Place of Presentation: みやこめっせ
• [Presentation] 長崎大学早期関節炎コホートによる2010年ACR/EULAR RA分類基準の検証
  • Author(s): 玉井慎美
  • Organizer: 第109回日本内科学会総会
  • Place of Presentation: みやこめっせ
• [Presentation] MRI骨炎は早期RAのrapid radiographic progressionへの進展を予測する
  • Author(s): 玉井慎美
  • Organizer: 第27回日本臨床リウマチ学会
  • Place of Presentation: 神戸ポートピアホテル
• [Presentation] Presence of osteitis on magnetic resonance imaging during 2 years follow-up is an independent predictor for radiographic progression in early rheumatoid arthritis
  • Author(s): Tamai M
  • Organizer: EULAR 2012
  • Place of Presentation: Messe Berlin (Berlin, Germany)
• [Presentation] Magnetic resonance imaging-proven osteitis at baseline predicts the development of rapid radiographic progression in patients with early rheumatoid arthritis
  • Author(s): Tamai M
  • Organizer: ACR 2012
  • Place of Presentation: Washington Convention Center (Washington D.C., USA)