| Project/Area Number |
24591462
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
膠原病・アレルギー・感染症内科学
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| Research Institution | Niigata University |
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Principal Investigator |
KOYA TOSHIYUKI 新潟大学, 医歯学総合病院, 講師 (90444158)
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Takashi 新潟大学, 医歯学総合病院, 准教授 (90361906)
SAKAGAMI Takuro 新潟大学, 医歯学系, 助教 (00444159)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 気管支喘息 / 舌下免疫療法 / Dermatophagoides farina / IgA / 免疫寛容 / アナフィラキシー / 動物モデル |
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| Outline of Final Research Achievements |
Allergen specific sublingual immunotherapy is less of anaphylaxic reactions and is possible to maintain the therapy at home. However, the mechanisms of immunotherapy, including sublingual immunotherapy, are not elucidated entirely. In this study, we used Dermatophagoides farina-specific asthma model and executed sublingual immunotherapy to them. In sublingual immunothepy groups, airway hyperresponsiveness to methacholine, airway eosinophilic inflammation and airway remodeling were suppressed compared to control group. Serum IgE levels were decreased and IgG levels were increased after immunotherapy. Moreover, IgA levels of BAL fluid were also increased compared to control group. These data suggested that increasing IgG or IgA presumably play as a blocking antibody to mast cell and the alteration of dendritic cell function through Fc receptor might be the mechanism of immunotherapy.
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