Elucidation and therapeutic application of the role of matricellular proteins in allergic inflammation

• Project/Area Number: 24591466
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Saga University
• Principal Investigator: OHTA SHOICHIRO 佐賀大学, 医学部, 助教 (20346886)
• Co-Investigator(Kenkyū-buntansha): IZUHARA Kenji 佐賀大学, 医学部, 教授 (00270463)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: ペリオスチン / マトリセルラータンパク質 / アレルギー

Outline of Final Research Achievements

Periostin, a matricellular protein, plays a critical role in atopic dermatitis. In this study, we aimed to elucidate the function of periostin in the inflammatory signaling by identifyig periostin receptors, and to establish antagonistic anti-periostin monoclonal antibodies as molecularly-targeted drugs. As a result, we identified an integrin-binding domain on the periostin molecule, and found integrin independent cellular binding to periostin. More over, we established several antagonistic anti-periostin antibodies. They promise the therapeutic application of periostin for allergic diseases.

Research Products

• [Journal Article] Periostin in Allergic Inflammation (2014)
  • Author(s): Kenji Izuhara, Kazuhiko Arima, Shoichiro Ohta, Shoichi Suzuki, Masako Inamitsu, and Ken-ichi Yamamoto
  • Journal Title: Allergology International Volume: 63 Issue: 2 Pages: 143-151
  • DOI: 10.2332/allergolint.13-RAI-0663
  • NAID: 130004477217
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Periostin Controls Keratinocyte Proliferation and Differentiation by Interacting with the Paracrine IL-1α/IL-6 Loop. (2014)
  • Author(s): Kazuto Taniguchj, Kazuhiko Arima, Miho Masuoka, Shoichiro Ohta, Hiroshi Shiraishi, Kanako Ontsuka, Shoichi Suzuki, Masako Inamitsu, and Ken-ichi Yamamoto, Olga Simmons, Shuji Toda, Simon J Conway, Yuhei Hamasaki, and Kenji Izuhara
  • Journal Title: Journal of Investigative Dermatology Volume: 134 Issue: 5 Pages: 1246-1254
  • DOI: 10.1038/jid.2013.523
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Integrating longitudinal information on pulmonary function and inflammation using asthma phenotypes. (2014)
  • Author(s): Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M
  • Journal Title: J Allergy Clin Immunol Volume: 133 Issue: 5 Pages: 1474-1477
  • DOI: 10.1016/j.jaci.2013.12.1084
  • Peer Reviewed / Open Access
• [Journal Article] GLCCI1 variant accelerates pulmonary function decline in patients with asthma receiving inhaled corticosteroids. (2014)
  • Author(s): Izuhara Y, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Ohnishi H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Oguma T, Inoue H, Tajiri T, Iwata T, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M.
  • Journal Title: Allergy Volume: 69 Issue: 5 Pages: 668-73
  • DOI: 10.1111/all.12400
  • Peer Reviewed / Open Access
• [Journal Article] Osteopontin and periostin are associated with a 20-year decline of pulmonary function in patients with asthma. (2014)
  • Author(s): Kanemitsu Y, Ito I, Niimi A, Izuhara K, Ohta S, Ono J, Iwata T, Matsumoto H, Mishima M
  • Journal Title: Am J Respir Crit Care Med Volume: 190 Issue: 4 Pages: 472-474
  • DOI: 10.1164/rccm.201403-0562le
  • Peer Reviewed / Open Access
• [Journal Article] 佐賀大学医学部附属病院における新生児聴覚スクリーニングの現状 (2014)
  • Author(s): 宇木望、田辺一郎、東谷孝徳、太田昭一郎、末岡榮三朗
  • Journal Title: 医学検査 Volume: 63 Pages: 283-287
  • NAID: 130004601853
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Periostin levels correlate disease severity and chronicity in patients with atopic dermatitis. (2014)
  • Author(s): Kenzen Kou, Tomoko Okawa, Yukie Yamaguchi, Junya Ono, Yusuke Inoue, Masumi Kohno, Setsuko Matsukura, Tsuyoshi Kambara, Shoichiro Ohta, Kenji Izuhara, and Michiko Aihara
  • Journal Title: British Journal of Dermatology Volume: 171 Issue: 2 Pages: 283-291
  • DOI: 10.1111/bjd.12943
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 気管支喘息における新規生物学的製剤開発の可能性を探る IL-4/IL-13 (2014)
  • Author(s): 太田昭一郎、出原賢治
  • Journal Title: Respiratory Medical Research Volume: 2 Pages: 152-157
• [Journal Article] Association of serum periostin with aspirin-exacerbated respiratory disease. (2014)
  • Author(s): Mi-Ae Kim, Kenji Izuhara, Shoichiro Ohta, Junya Ono, Moon Kyung Yoon, MS, Ga Young Ban, Hye-Soo Yoo, Yoo Seob Shin, Young-Min Ye, Dong-Ho Nahm, and Hae-Sim Park
  • Journal Title: Annals of Allergy, Asthma & Immunology Volume: 113 Issue: 3 Pages: 314-320
  • DOI: 10.1016/j.anai.2014.06.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Using exhaled nitric oxide and serum periostin as a composite marker to identify severe/steroid-insensitive asthma. (2014)
  • Author(s): Nagasaki T, Matsumoto H, Kanemitsu Y, Izuhara K, Tohda Y, Horiguchi T, Kita H, Tomii K, Fujimura M, Yokoyama A, Nakano Y, Hozawa S, Ito I, Oguma T, Izuhara Y, Tajiri T, Iwata T, Ono J, Ohta S, Yokoyama T, Niimi A, Mishima M.
  • Journal Title: Am J Respir Crit Care Med Volume: 190 Issue: 12 Pages: 1449-1452
  • DOI: 10.1164/rccm.201407-1290le
  • NAID: 40020962796
  • Peer Reviewed / Open Access
• [Journal Article] バイオマーカーとは—ペリオスチンを中心に— (2014)
  • Author(s): 太田昭一郎、出原賢治
  • Journal Title: 日本呼吸器学会誌 Volume: 3 Pages: 617-624
  • Acknowledgement Compliant
• [Journal Article] Inhibition of antibody production in vivo by pre-stimulation of Toll-like receptor 4 before antigen priming is caused by defective B cell priming and not impairment in antigen presentation. (2013)
  • Author(s): Nurlaely Mida Rachmawati, Kenji Fukudome, Naoko Tsuneyoshi, Uleng Bahrun, Hiroki Tsukamoto, Tsutomu Yanagibashi, Yoshinori Nagai, Kiyoshi Takatsu, Shoichiro Ohta, and Masao Kimoto
  • Journal Title: International Immunology Volume: 25 Issue: 2 Pages: 117-128
  • DOI: 10.1093/intimm/dxs096
  • Peer Reviewed
• [Journal Article] Serum periostin levels are correlated with progressive skin sclerosis in patients with systemic sclerosis. (2013)
  • Author(s): Yamaguchi Y
  • Journal Title: British Journal of Dermatology Volume: 168(4) Issue: 4 Pages: 717-725
  • DOI: 10.1111/bjd.12117
  • Peer Reviewed
• [Journal Article] Increased periostin associates with greater airflow limitation in patients receiving inhaled corticosteroids (2013)
  • Author(s): Kanemitsu Y, Mishima M,et al.
  • Journal Title: J Allergy Clin Immunol Volume: 132 Issue: 2 Pages: 305-312
  • DOI: 10.1016/j.jaci.2013.04.050
  • NAID: 120005342661
  • Peer Reviewed
• [Journal Article] Efficacy of omalizumab in eosinophilic chronic rhinosinusitis patients with asthma. (2013)
  • Author(s): Tajiri T, Matsumoto H, Hiraumi H, Ikeda H, Morita K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Ito J, Niimi A, Mishima M.
  • Journal Title: Ann Allergy Asthma Immunol. Volume: 110 Issue: 5 Pages: 387-8
  • DOI: 10.1016/j.anai.2013.01.024
  • Peer Reviewed
• [Journal Article] Yokukansan Treatment of Chronic Renal Failure Patients Receiving Hemodialysis, With Behavioral and Psychological Symptoms of Dementia: An Open-Label Study. (2013)
  • Author(s): Hidenori Sumiyoshi, Akio Mantani, Satoshi Nishiyama, Soh Fujiwaki, Shoichiro Ohta, Yoshikazu Masuda, Youhei Tomita, Naofumi Tarumoto, and Shigeto Yamawaki
  • Journal Title: American Journal of Geriatric Psychiatry Volume: 21 Issue: 11 Pages: 1082-1085
  • DOI: 10.1016/j.jagp.2011.06.001
  • Peer Reviewed
• [Journal Article] Reduced surface expression of TLR4 by a V254I point mutation accounts for the low lipopolysaccharide responder phenotype of BALB/c B cells. (2013)
  • Author(s): Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Ohta S, Nagai Y, Ihara H, Miyake K, Ikeda Y, Kimoto M
  • Journal Title: J. Immunol. Volume: 190 Issue: 1 Pages: 195-204
  • DOI: 10.4049/jimmunol.1201047
  • Peer Reviewed
• [Journal Article] ペリオスチン：臨床応用の可能性 (2013)
  • Author(s): 太田昭一郎、出原賢治
  • Journal Title: アレルギー Volume: 62 Pages: 652-664
• [Journal Article] 間質性肺炎の新規バイオマーカー：ペリオスチン (2013)
  • Author(s): 太田昭一郎、出原賢治
  • Journal Title: 臨床化学 Volume: 42 Pages: 346-353
• [Journal Article] オーダーメイド医療を目指したアレルギー疾患における病因診断システムの確立 ―アトピー性皮膚炎の新規バイオマーカーの同定と血中濃度解析― (2013)
  • Author(s): 太田昭一郎、谷口一登、有馬和彦、鈴木章一、白石裕士、増岡美穂、出原賢治
  • Journal Title: 臨床病理 Volume: 61 Pages: 247-255
  • NAID: 10031171352
• [Journal Article] 気管支喘息の研究 アップデート I．気管支喘息の分子病態 (2013)
  • Author(s): 出原賢治、鈴木章一、有馬和彦、稲光正子、山本健一、増岡美穂、太田昭一郎
  • Journal Title: アレルギー・免疫 Volume: 20 Pages: 958-964
• [Journal Article] 基礎研究の炎症疾患診断薬・治療薬開発への応用 (2013)
  • Author(s): 出原賢治、太田昭一郎、有馬和彦、鈴木章一、稲光正子、山本健一
  • Journal Title: 臨床病理 Volume: 61 Pages: 900-908
• [Journal Article] Markers that can Reflect Asthmatic Activity before and after Reduction of Inhaled Corticosteroids: A Pilot Study (2013)
  • Author(s): Go Kato, Koichiro Takahashi, Kenji Izuhara, Kazutoshi Komiya, Shinya Kimura and Shinichiro Hayashi
  • Journal Title: Biomarker Insights Volume: 8 Pages: 97-105
  • DOI: 10.4137/bmi.s12537
  • Peer Reviewed
• [Journal Article] Roles of TGF-beta and periostin in fibrosclerosis in patients with IgG4-related diseases. (2013)
  • Author(s): Ohta N, Kurakami K, Ishida A, Furukawa T, Suzuki Y, Aoyagi M, Matsubara A, Izuhara K, Kakehara S.
  • Journal Title: Acta Oto-laryngologica Volume: 133 Issue: 12 Pages: 1322-1327
  • DOI: 10.3109/00016489.2013.831187
  • Peer Reviewed
• [Journal Article] Clinical and pathological characteristics of organized hematoma. (2013)
  • Author(s): Ohta N, Watanabe T, Ito T, Kubota T, Suzuki Y, Ishida A, Kakehata S, Aoyagi M, Matsubara M, Izuhara K, Kakehata S.
  • Journal Title: International Journal of Otolaryngology Volume: 132 Pages: 305-312
  • DOI: 10.1155/2013/539642
  • Peer Reviewed
• [Journal Article] The usefulness of combined measurements of squamous cell carcinoma antigens 1 and 2 in diagnosing atopic dermatitis (2012)
  • Author(s): Shoichiro Ohta
  • Journal Title: Annals of Clinical Biochemistry Volume: (in press) Issue: 3 Pages: 277-284
  • DOI: 10.1258/acb.2011.011065
  • Peer Reviewed
• [Journal Article] Periostin, a matricellular protein, accelerates cutaneous wound repair by activating dermal fibroblasts (2012)
  • Author(s): Ontsuka K, Kotobuki Y, Shiraishi H, Serada S, Ohta S, Tanemura A, Yang L, Fujimoto M, Arima K, Suzuki S, Murota H, Toda S, Kudo A, Conway S, Izuhara K, Katayama I, Naka T
  • Journal Title: Experimental Dermatology Volume: 21(5) Issue: 5 Pages: 331-336
  • DOI: 10.1111/j.1600-0625.2012.01454.x
  • Peer Reviewed
• [Journal Article] Periostin, a matricellular protein, plays a role in the induction of chemokines in pulmonary fibrosis (2012)
  • Author(s): Uchida M, Shiraishi H, Ohta S, Arima K, Taniguchi K, Suzuki S, Okamoto M, Ahlfeld SK, Ohshima K, Kato S, Toda S, Sagara H, Aizawa H, Hoshino T, Conway SJ, Hayashi S, Izuhara K
  • Journal Title: Am J Respir Cell Mol Biol Volume: (In press) Issue: 5 Pages: 677-686
  • DOI: 10.1165/rcmb.2011-0115oc
  • Peer Reviewed
• [Journal Article] The RP105/MD-1 complex is indispensable for TLR4/MD-2-dependent proliferation and IgM-secreting plasma cell differentiation of marginal zone B cells (2012)
  • Author(s): Yoshinori Nagai
  • Journal Title: International Immunology Volume: (in press) Issue: 6 Pages: 389-400
  • DOI: 10.1093/intimm/dxs040
  • Peer Reviewed
• [Journal Article] Periostin promotes chronic allergic inflammation in response to Th2 cytokines. (2012)
  • Author(s): Masuoka M, Shiraishi H, Ohta S, Suzuki S, Arima K, Aoki S, Toda S, Inagaki N, Kurihara Y, Hayashida S, Takeuchi S, Koike K, Ono J, Noshiro H, Furue M, Conway SJ, Narisawa Y, Izuhara K.
  • Journal Title: J Clin Invest Volume: 122 Issue: 7 Pages: 2590-2600
  • DOI: 10.1172/jci58978
  • Peer Reviewed
• [Journal Article] Periostin Contributes to the Pathogenesis of Atopic Dermatitis by Inducing TSLP Production from Keratinocytes (2012)
  • Author(s): Shiraishi H, Masuoka M, Ohta S, Suzuki S, Arima K, Taniguchi K, Aoki S, Toda S, Yoshimoto T, Inagaki N, Conway SJ, Narisawa Y, Izuhara K
  • Journal Title: Allergology International Volume: 61 Issue: 4 Pages: 563-572
  • DOI: 10.2332/allergolint.10-OA-0297
  • NAID: 130004873049
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Presentation] Injury promotes melanoma metastasis via wound healing process with periostin. (2014)
  • Author(s): 福田桂太郎、杉原英志、太田昭一郎、出原賢治、佐谷秀行、天谷雅行
  • Organizer: 日本研究皮膚科学会 第39回年次学術大会・総会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-12-12 – 2014-12-14
• [Presentation] Periostin contributes to epidermal hyperplasia in psoriasis common to atopic dermatitis. (2014)
  • Author(s): Kazuhiko Arima, Shoichiro Ohta, Hiroshi Shiraishi, Miho Masuoka, Kanako Ontsuka, Shoichi Suzuki, Hajime Sutoh, Shigaku Ikeda, and Kenji Izuhara
  • Organizer: 第43回日本免疫学会総会学術総会
  • Place of Presentation: 京都市
  • Year and Date: 2014-12-10 – 2014-12-12
• [Presentation] 病理検体受付時における依頼内容の不備・不一致事案についての解析 (2014)
  • Author(s): 久米修二、中村光男、次富久之、甲斐啓太、東谷孝徳、太田昭一郎、末岡榮三朗
  • Organizer: 第61回日本臨床検査医学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-11-22 – 2014-11-25
• [Presentation] イオン化Ca推定式の検討 (2014)
  • Author(s): 池田弘典、川崎誠司、東谷孝徳、太田昭一郎、末岡榮三朗
  • Organizer: 第61回日本臨床検査医学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-11-22 – 2014-11-25
• [Presentation] 稀なグラム陰性らせん菌感染症を血液培養で証明できた2症例 (2014)
  • Author(s): 橋本優佑、小松千夏、於保恵、草場耕二、東谷孝徳、太田昭一郎、末岡榮三朗、林真一郎
  • Organizer: 第61回日本臨床検査医学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-11-22 – 2014-11-25
• [Presentation] 術前呼吸機能検査における換気障害保有率と検査結果の活用調査 (2014)
  • Author(s): 石隈まや、安藤彩、前田淳也、宇木望、西村忠隆、田辺一郎、川崎誠司、東谷孝徳、太田昭一郎、末岡榮三朗、林真一郎
  • Organizer: 第61回日本臨床検査医学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-11-22 – 2014-11-25
• [Presentation] 佐賀大学医学部附属病院検査部における実習教育の現状分析 (2014)
  • Author(s): 東谷孝徳、若山一夫、川崎誠司、杉町光彦、中村光男、山田尚友、田辺一郎、草場耕治、太田昭一郎、末岡榮三朗
  • Organizer: 第61回日本臨床検査医学会学術集会
  • Place of Presentation: 福岡市
  • Year and Date: 2014-11-22 – 2014-11-25
• [Presentation] オシレーション法における呼吸条件の検討 (2014)
  • Author(s): 宇木望，田辺一郎，東谷孝徳，太田昭一郎，末岡栄三朗
  • Organizer: 平成26年度日臨技九州支部医学検査学会（第49回）
  • Place of Presentation: 那覇市
  • Year and Date: 2014-11-01 – 2014-11-02
• [Presentation] 損傷は治癒過程に惹起されるペリオスチンを介してメラノーマの転移を促進する (2014)
  • Author(s): 福田桂太郎、杉原英志、太田昭一郎、出原賢治、天谷雅行、佐谷秀行
  • Organizer: 第73回日本癌学会学術総会
  • Place of Presentation: 横浜市
  • Year and Date: 2014-09-25 – 2014-09-27
• [Presentation] 難治性喘息患者における血清ペリオスチン濃度と呼吸機能・副鼻腔陰影重症度の関連 (2014)
  • Author(s): 木村孔一、今野哲、中丸裕、牧田比呂仁、谷口菜津子、清水薫子、前田由起子、鈴木雅、長井桂、小野純也、太田昭一郎、出原賢治、西村正治
  • Organizer: 第79回日本インターフェロン・サイトカイン学会学術集会
  • Place of Presentation: 札幌市
  • Year and Date: 2014-06-19 – 2014-06-20
• [Presentation] Periostin, a novel biomarker for IPF (2014)
  • Author(s): Shoichiro Ohta
  • Organizer: MRC SORT-IPF Workshop
  • Place of Presentation: Winchester, UK
  • Year and Date: 2014-06-13 – 2014-06-14
  • Invited
• [Presentation] 当院におけるCV R-R検査の現状と結果の判定 (2014)
  • Author(s): 安藤彩、前田淳也、宇木望、石隈麻耶、西村忠隆、田辺一郎、東谷孝徳、太田昭一郎、末岡榮三朗
  • Organizer: 第63回日本医学検査学会
  • Place of Presentation: 新潟市
  • Year and Date: 2014-05-17 – 2014-05-18
• [Presentation] 心臓超音波検査における推定右房圧と心臓カテーテル検査による右房圧の比較検討 (2014)
  • Author(s): 前田淳也、安藤彩、宇木望、石隈麻耶、梅木俊晴、西村忠隆、田辺一郎、東谷孝徳、太田昭一郎、末岡榮三朗
  • Organizer: 第63回日本医学検査学会
  • Place of Presentation: 新潟市
  • Year and Date: 2014-05-17 – 2014-05-18
• [Presentation] 極めてまれなBrachyspira pilosicoliにより発症した腸炎・菌血症の1症例 (2014)
  • Author(s): 於保恵、橋本優佑、草場耕二、東谷孝徳、太田昭一郎、宮本比呂志、末岡榮三朗
  • Organizer: 第63回日本医学検査学会
  • Place of Presentation: 新潟市
  • Year and Date: 2014-05-17 – 2014-05-18
• [Presentation] Effect of allergen challenge on two novel biomarkars of airway inflammation, periostin and YKL-40, in atopic asthmatic patients. (2014)
  • Author(s): 126.Anna James, Anne Gomes, Kameran Daham, Junya Ono, Shoichiro Ohta, Barbro Dahlén, Kenji Izuhara, and Sven-Erik Dahlén
  • Organizer: 2014 American Thoracic Society International Conference
  • Place of Presentation: San Diego, CA, USA
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] オステオポンチンとペリオスチンは喘息患者の長期的な呼吸機能低下に寄与する (2014)
  • Author(s): 金光禎寛，伊藤功朗，新実彰男，松本久子，岩田敏之，出原賢治，太田昭一郎，小野純也，小熊毅，田尻智子，長崎忠雄，出原裕美，三嶋理晃
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪市
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] The IL-1α/periostin/IL-6 axis contributes to the keratinocyte proliferation and differentiation on atopic dermatitis. (2013)
  • Author(s): Izuhara K, Taniguchi K, Arima K, Masuoka M, Shiraishi H, Ohta S, Ontsuka K, Suzuki S, Hamasaki Y, Conway SJ.
  • Organizer: Pathogenic Processes in Asthma and COPD, Keystone Symposia
  • Place of Presentation: Santa Fe, New Mexico
• [Presentation] Controlled oral steroid intervention decreases serum periostin levels in asthmatic patients. (2013)
  • Author(s): Anna James, Junya Ono, Shoichiro Ohta, Maciek Kupczyk, Kenji Izuhara, and Sven-Erik Dahlén on behalf of the BIOAIR group
  • Organizer: 2013 American Thoracic Society International Conference
  • Place of Presentation: Philadelphia, PA
• [Presentation] Relationship Between Serum Periostin Levels And Severity/Phenotype Of Asthma. (2013)
  • Author(s): Kabata H, Matsuoka M, Fukunaga K, Suzuki Y, Miyata J, Tanaka K, Masaki K, Mochimaru T, Ono J, Ohta S, Izuhara K, Asano K, Betsuyaku T
  • Organizer: 2013 American Thoracic Society International Conference
  • Place of Presentation: Philadelphia, PA
• [Presentation] Periostin associates with greater pulmonary function decline in asthmatic patients on treatment. (2013)
  • Author(s): Kanemitsu Y, Matsumoto H, Izuhara K, Tohda Y, Kita H, Horiguchi T, Kuwabara K, Tomii K, Otsuka K, Fujimura M, Ohkura N, Tomita K, Yokoyama A, Oh H, Nakano Y, Oguma T, Hozawa S, Nagasaki T, Ito I, Inoue H, Tajiri T, Iwata T, Izuhara Y, Ono J, Ohta S, Tamari M, Hirota T, Yokoyama T, Niimi A, Mishima M
  • Organizer: 2013 American Thoracic Society International Conference
  • Place of Presentation: Philadelphia, PA
• [Presentation] Efficacy Of Omalizumab In Asthmatic Patients With Eosinophilic Chronic Rhinosinusitis Or Eosinophilic Otitis Media. (2013)
  • Author(s): Tajiri T, Matsumoto H, Hiraumi H, Ikeda H, Morita K, Izuhara K, Ono J, Ohta S, Ito I, Oguma T, Nakaji H, Inoue H, Iwata T, Nagasaki T, Kanemitsu Y, Ito J, Niimi A, Mishima M
  • Organizer: 2013 American Thoracic Society International Conference
  • Place of Presentation: Philadelphia, PA
• [Presentation] TH2 specific biomarker profile determines steroid responsiveness in severe asthma. (2013)
  • Author(s): Anna James, Maciek Kupczyk, Junya Ono, Shoichiro Ohta, Kenji Izuhara, and Sven-Erik Dahlén
  • Organizer: European Respiratory Society Annual Congress 2013
  • Place of Presentation: Barcelona, Spain
• [Presentation] Asthma phenotypes with rapid decline in lung function. (2013)
  • Author(s): T. Nagasaki et al.
  • Organizer: European Respiratory Society Annual Congress 2013
  • Place of Presentation: Barcelona, Spain
• [Presentation] Association between ADAM33 polymorphisms and asthma control. (2013)
  • Author(s): G. Petrova, H et al.
  • Organizer: European Respiratory Society Annual Congress 2013
  • Place of Presentation: Barcelona, Spain
• [Presentation] Periostin. (2013)
  • Author(s): Izuhara K
  • Organizer: EAACI-WAO World Allergy & Asthma Congress
  • Place of Presentation: Milan, Italy
  • Invited
• [Presentation] Novel biomarkers for severe asthma. (2013)
  • Author(s): Izuhara K
  • Organizer: EAACI-WAO World Allergy & Asthma Congress
  • Place of Presentation: Milan, Italy
  • Invited
• [Presentation] The IL-1alpha/periostin/IL-6 axis contributes to the keratinocyte proliferation and differentiation in atopic dermatitis (2012)
  • Author(s): Kazuto Taniguchi et al.
  • Organizer: 29th Symposium of the Collegium Internationale Allergologicum
  • Place of Presentation: Jeju Island, Korea
• [Presentation] Increased Periostin Levels in Patients with Systemic Sclerosis (2012)
  • Author(s): Yukie Yamaguchi et al.
  • Organizer: 2012 American College of Rheumatology/Associations of Rheumatology Health Professionals (ACR/ARHP) Annual Meeting
  • Place of Presentation: Washington D.C., USA
• [Book] Metabolism of Human Diseases (2014)
  • Author(s): Kenji Izuhara, Shoichi Suzuki, Kazuhiko Arima, Shoichiro Ohta, Masako Inamitsu, and Ken-ichi Yamamoto
  • Total Pages: 416
  • Publisher: Springer-Verlag, Wien, Austria
• [Book] Allegic Diseases: from Mechanisms to Cures. (2014)
  • Author(s): Kenji Izuhara, Hisako Matsumoto, Yoshihiro Kanemitsu, Shoichiro Ohta, Junya Ono, M. Mishima, and on behalf of Kinki Hokuriku Airway Disease Conference
  • Total Pages: 255
  • Publisher: Pacini Editore S.p.A, Pisa, Italy
• [Book] 実験医学増刊 Vol.31 No.17 病態の理解に向かうアレルギー疾患研究-なぜ、アレルギーが起こるのか? 発症・進展の新概念と臨床への展開． (2013)
  • Author(s): 有馬 和彦，出原 賢治
  • Total Pages: 209
  • Publisher: 羊土社．東京
• [Book] Atopic dermatitis―Disease etiology and clinical management (2012)
  • Author(s): Kenji Izuhara et al.
  • Publisher: InTech, Rijeka, Croatia
• [Book] Translational Science: from Basic to Clinical Immunology and Allergy (2012)
  • Author(s): Kenji Izuhara et al.
  • Publisher: Pacini Editore S.p.A., Pisa, Italy
• [Remarks] 佐賀大学医学部分子生命科学講座分子医化学分野
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Remarks] 分子医化学ホームページ
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Remarks] 佐賀大学医学部分子生命科学講座
  • URL: http://www.biomol.med.saga-u.ac.jp/medbiochem/index.php
• [Patent(Industrial Property Rights)] 気管支喘息の予防又は治療薬及びそのスクリーニング方法 (2014)
  • Inventor(s): 太田昭一郎、他
  • Industrial Property Rights Holder: 太田昭一郎、他
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-555252
  • Filing Date: 2014-05-21
• [Patent(Industrial Property Rights)] 眼科疾患を除くペリオスチン発現に起因する疾患用医薬、およびその用途 (2014)
  • Inventor(s): 太田昭一郎、他
  • Industrial Property Rights Holder: 太田昭一郎、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-09-26
  • Overseas
• [Patent(Industrial Property Rights)] アトピー性角結膜炎の検出方法 (2014)
  • Inventor(s): 太田昭一郎、他
  • Industrial Property Rights Holder: 太田昭一郎、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-10-17
  • Overseas
• [Patent(Industrial Property Rights)] 慢性副鼻腔炎の検出方法（US） (2014)
  • Inventor(s): 太田昭一郎、他
  • Industrial Property Rights Holder: 太田昭一郎、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-04-25
  • Overseas
• [Patent(Industrial Property Rights)] 慢性副鼻腔炎の検出方法（EP） (2014)
  • Inventor(s): 太田昭一郎、他
  • Industrial Property Rights Holder: 太田昭一郎、他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-04-25
  • Overseas
• [Patent(Industrial Property Rights)] ペリオスチンの特定領域に結合する抗体、及びこれを用いたペリオスチンの測定方法 (2014)
  • Inventor(s): 出原賢治、太田昭一郎 他
  • Industrial Property Rights Holder: 出原賢治、太田昭一郎 他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2014-02-26
  • Overseas
• [Patent(Industrial Property Rights)] 眼科疾患を除くぺリオスチン発現に起因する疾患用医薬、およびその用途 (2013)
  • Inventor(s): 出原賢治、太田昭一郎 他
  • Industrial Property Rights Holder: 出原賢治、太田昭一郎 他
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-202051
  • Filing Date: 2013-09-27
• [Patent(Industrial Property Rights)] アトピー性角結膜炎の検出法 (2013)
  • Inventor(s): 出原賢治、太田昭一郎 他
  • Industrial Property Rights Holder: 出原賢治、太田昭一郎 他
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2013-218612
  • Filing Date: 2013-10-21
• [Patent(Industrial Property Rights)] 気管支喘息の予防又は治療薬及びそのスクリーニング方法 (2013)
  • Inventor(s): 太田昭一郎 他
  • Industrial Property Rights Holder: 太田昭一郎 他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-01-22
  • Overseas
• [Patent(Industrial Property Rights)] ペリオスチンの特定領域に結合する抗体及びこれを用いたペリオスチンの測定方法 (2012)
  • Inventor(s): 太田昭一郎 他
  • Industrial Property Rights Holder: 太田昭一郎 他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-09-06
  • Overseas
• [Patent(Industrial Property Rights)] 慢性副鼻腔炎の検出方法 (2012)
  • Inventor(s): 太田昭一郎 他
  • Industrial Property Rights Holder: 太田昭一郎 他
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-10-29
  • Overseas