IL-33 expression in lymphoid tissues

• Project/Area Number: 24591475
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: 膠原病・アレルギー・感染症内科学
• Research Institution: Tokyo Metropolitan Institute of Medical Science (2013-2014); National Research Institute for Child Health and Development (2012)
• Principal Investigator: OBOKI Keisuke 公益財団法人東京都医学総合研究所, ゲノム医科学研究分野, 主席研究員 (80415108)
• Project Period (FY): 2012-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: IL-33

Outline of Final Research Achievements

Clarification of IL-33-expressing cells and the regulatory mechanisms of IL-33 expression have a potential for identification of a new drug for asthma. Recently, another research reported IL-33 reporter mice on Journal of Immunology, 2012. Thus, we have attempted to study by another approach. Besides, a collaborative study which reported IL-33 function in memory Th2 cells has been published (Immunity 2015). Furthermore, given that Gauvreau et al.(2014) reported that anti-TSLP Ab treatment would be a promising drug for asthma (TSLP is one of the asthma-related genes reported form GWAS studies), it is also expected that inhibition of IL-33 or of IL-33-IL-33R pathway will show the possibility of success as a novel promising drug-target for asthma (IL-33 and IL-33R are also asthma-related genes reported from GWAS studies).

Research Products

• [Journal Article] The Interleukin-33-p38 Kinase Axis Confers Memory T Helper 2 Cell Pathogenicity in the Airway. (2015)
  • Author(s): Endo, Y., Hirahara, K., Iinuma, T., Shinoda, K., Tumes, D. J., Asou, H. K., Matsugae, N., Obata-Ninomiya, K., Yamamoto, H., Motohashi, S., Oboki, K, Nakae, S., Saito, H., Okamoto, Y., and Nakayama, T.
  • Journal Title: Immunity Volume: 42(2) Issue: 2 Pages: 294-308
  • DOI: 10.1016/j.immuni.2015.01.016
  • Peer Reviewed / Open Access
• [Journal Article] Critical Roles for PU.1, GATA1, and GATA2 in the Expression of Human FcεRI on Mast Cells: PU.1 and GATA1 Transactivate FCER1A, and GATA2 Transactivates FCER1A and MS4A2 (2014)
  • Author(s): Inage E, Kasakura K, Yashiro T, Suzuki R, Baba Y, Nakano N, Hara M, Tanabe A, Oboki K, Matsumoto K, Saito H, Niyonsaba F, Ohtsuka Y, Ogawa H, Okumura K, Shimizu T, and Nishiyama C
  • Journal Title: Journal of Immunology Volume: 192 Issue: 8 Pages: 3936-46
  • DOI: 10.4049/jimmunol.1302366
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] ATF7IP as a novel PDGFRB fusion partner in acute lymphoblastic leukaemia in children. (2014)
  • Author(s): Kobayashi K, Mitsui K, Ichikawa H, Nakabayashi K, Matsuoka M, Kojima Y, Takahashi H, Iijima K, Ootsubo K, Oboki K, Okita H, Yasuda K, Sakamoto H, Hata K, Yoshida T, Matsumoto K, Kiyokawa N, Ohara A.
  • Journal Title: Br J Haematol Volume: 165 Issue: 6 Pages: 836-41
  • DOI: 10.1111/bjh.12834
  • Peer Reviewed / Open Access
• [Journal Article] Poor responses to tyrosine kinase inhibitors in a child with precursor B-cell acute lymphoblastic leukemia with SNX2-ABL1 chimeric transcript. (2014)
  • Author(s): Masuzawa A, Kiyotani C, Osumi T, Shioda Y, Iijima K, Tomita O, Nakabayashi K, Oboki K, Yasuda K, Sakamoto H, Ichikawa H, Hata K, Yoshida T, Matsumoto K, Kiyokawa N, Mori T.
  • Journal Title: Eur J Haematol. Volume: 92(3) Issue: 3 Pages: 263-267
  • DOI: 10.1111/ejh.12234
  • Peer Reviewed
• [Journal Article] IL-33-Mediated Innate Response and Adaptive Immune Cells Contribute to Maximum Responses of Protease Allergen-Induced Allergic Airway Inflammation. (2013)
  • Author(s): Kamijo S, Takeda H, Tokura T, Suzuki M, Inui K, Hara M, Matsuda H, Matsuda A, Oboki K, Ohno T, Saito H, Nakae S, Sudo K, Suto H, Ichikawa S, Ogawa H, Okumura K, Takai T.
  • Journal Title: J Immunol. Volume: 190(9) Pages: 4489-4499
  • Peer Reviewed
• [Journal Article] Epithelial cell-derived IL-25, but not Th17 cell-derived IL-17 or IL-17F, is crucial for murine asthma. (2012)
  • Author(s): Suzukawa M, Morita H, Nambu A, Arae K, Shimura E, Shibui A, Yamaguchi S, Suzukawa K, Nakanishi W, Oboki K, Kajiwara N, Ohno T, Ishii A, Koerner H, Cua DJ, Suto H, Yoshimoto T, Iwakura Y
  • Journal Title: J Immunol. Volume: 189 Pages: 3641-52
  • Peer Reviewed
• [Journal Article] ST2 Requires Th2-, but Not Th17-, Type Airway Inflammation in Epicutaneously Antigen-Sensitized Mice (2012)
  • Author(s): Morita H, Arae K, Ohno T, Kajiwara N, Oboki, K, Matsuda A, Suto H, Okumura K, Sudo K, Takahashi T, Matsumoto K, Nakae, S
  • Journal Title: Allergology International Volume: 61 Issue: 2 Pages: 265-273
  • DOI: 10.2332/allergolint.11-OA-0379
  • NAID: 130004477129
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed