| Project/Area Number |
24591478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Nobuhiro 福井大学, 医学部, 特別研究員 (90003409)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEGAYA Satoshi 福井大学, 医学部, 助教 (10324162)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 新興リケッチア感染症 / サイトカイン / 日本紅斑熱 / リケッチア感染症 / テトラサイクリン / オートファジー / 全身性炎症反応症候群 / 炎症性サイトカイン / ケモカイン / テトラサイクリン系抗菌剤 / チゲサイクリン / テトラサイクリン系薬剤 / キノロン系薬剤 |
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| Outline of Final Research Achievements |
The aspect of rickettsiosis in Japan has been changed during this study period. The first case of Shimokoshi type tsutsugamushi disease in Western Japan appeared at Fukui Prefecture in 2012. We found that 4 types tsutsugamushi diseases (TD) (Gilliam, Kawasaki, Karp, Shimokoshi) are exist in Fukui. The first case of Japanese spotted fever (JSF) in Fukui was also diagnosed in 2014. In this way, the field of rickettsial infection and pathogen's diversity are spreading.
It is suggested that minocycline is most effective for rickettsial infection, and the action mechanism of this antibiotics is dependent upon suppression of NFκB and regulation of autophagy under the in vitro assay.
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