Establishment of treatment for complicated spotted fever group rickettsioses on the basis of clinical analysis.
| Project/Area Number |
24591478
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | University of Fukui |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKADA Nobuhiro 福井大学, 医学部, 特別研究員 (90003409)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEGAYA Satoshi 福井大学, 医学部, 助教 (10324162)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 新興リケッチア感染症 / サイトカイン / 日本紅斑熱 / リケッチア感染症 / テトラサイクリン / オートファジー / 全身性炎症反応症候群 / 炎症性サイトカイン / ケモカイン / テトラサイクリン系抗菌剤 / チゲサイクリン / テトラサイクリン系薬剤 / キノロン系薬剤 |
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| Outline of Final Research Achievements |
The aspect of rickettsiosis in Japan has been changed during this study period. The first case of Shimokoshi type tsutsugamushi disease in Western Japan appeared at Fukui Prefecture in 2012. We found that 4 types tsutsugamushi diseases (TD) (Gilliam, Kawasaki, Karp, Shimokoshi) are exist in Fukui. The first case of Japanese spotted fever (JSF) in Fukui was also diagnosed in 2014. In this way, the field of rickettsial infection and pathogen's diversity are spreading.
It is suggested that minocycline is most effective for rickettsial infection, and the action mechanism of this antibiotics is dependent upon suppression of NFκB and regulation of autophagy under the in vitro assay.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Utility of PCR amplification and DNA microarray hybridization of 16S rDNA for rapid diagnosis of bacteremia associated with hematological diseases.2013
Author(s)
Negoro E, Iwasaki H, Tai K, Ikegaya S, Takagi K, Kishi S, Yamauchi T, Yoshida A, Urasaki Y, Shimadzu M, Ueda T.
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Journal Title
Int J Infect Dis
Volume: 17
Related Report
Peer Reviewed
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[Journal Article] Detectable Wilms' tumor-1 transcription at treatment completion is associated with poor prognosis of acute myeloid leukemia: a single institution's experience.2013
Author(s)
Yamauchi T, Negoro E, Lee S, Takai M, Matsuda Y, Takagi K, Kishi S, Tai K, Hosono N, Tasaki T, Ikegaya S, Yoshida A, Urasaki Y, Iwasaki H, Ueda T.
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Journal Title
Anticancer Res
Volume: 33
Pages: 3335-3340
Related Report
Peer Reviewed
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[Journal Article] A high serum uric acid level is associated with poor prognosis in patients with acute myeloid leukemia.2013
Author(s)
Yamauchi T, Negoro E, Lee S, Takai M, Matsuda Y, Takagi K, Kishi S, Tai K, Hosono N, Tasaki T, Ikegaya S, Inai K, Yoshida A, Urasaki Y, Iwasaki H, Ueda T.
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Journal Title
Anticancer Res
Volume: 33
Pages: 3947-3952
Related Report
Peer Reviewed
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[Journal Article] Utility of PCR amplification and DNA microarray hybridization of 16S rDNA for rapid diagnosis of bacteremia associated with hematological diseases.2012
Author(s)
Negoro E, Iwasaki H, Tai K, Ikegaya S, Takagi K, Kishi S, Yamauchi T, Yoshida A, Urasaki Y, Shimadzu M, Ueda T.
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Journal Title
Int J Infect Dis
Volume: 17(4)
Related Report
Peer Reviewed
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[Presentation] 福井県近隣発症のつつが虫病にみる重症化要因.2014
Author(s)
岩崎博道, 高田伸弘, 池ヶ谷諭史, 田居克規, 酒巻一平, 重見博子, 矢野泰弘, 上田孝典.
Organizer
第69回日本衛生動物学会西日本支部大会・第9回日本衛生動物学会西日本支部例会.
Place of Presentation
長久手市, 愛知医科大学
Year and Date
2014-11-08 – 2014-11-09
Related Report
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