Analysis of treatment failure and relapse in young children with acute otitis media caused by Haemophilus influenzae
| Project/Area Number |
24591495
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Infectious disease medicine
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| Research Institution | Kurume University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
HATA Ryou 久留米大学, 医学部, 助教 (40461404)
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| Project Period (FY) |
2012-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | インフルエンザ菌 / 感染症難治化 / 薬剤耐性 / バイオフィルム / 細胞内侵入 / BLNAR / 細胞内寄生 / 治療戦略 |
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| Outline of Final Research Achievements |
Drug susceptibility testing, biofilm productions, and the intracellular invasion rate were investigated. Furthermore, human respiratory epithelial cells were previously infected by beta-lactamase-negative ampicillin-resistant Haemophilus influenzae (BLNAR) strains, and the morphological changes of BLNAR strains were observed using a focused ion beam (FIB / SEM) system after the continuous administration of cefotaxime and tosufloxacin. As a result, significant morphological changes, such as deformation and rupture were observed from not only bacteria on the surface of epithelial cells, but those invaded the cells. According to our results, a high bactericidal action of tosufloxacin has been proven, which suggested that it may become an effective agent for treating refractory pediatric otitis media.
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Report
(4 results)
Research Products
(104 results)
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[Journal Article] Dengue Hemorrhagic Fever in a Japanese Traveler with Pre-existing Japanese Encephalitis Virus Antibody2015
Author(s)
Sato R, Hamada N, Kashiwagi T, Imamura Y, Hara K, Naito Y, Koga N, Nishimura M, Kamimura T, Takasaki T, Watanabe H, and Koga T.
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Journal Title
Tropical Medicine and Health
Volume: 43
Issue: 2
Pages: 85-88
DOI
NAID
ISSN
1348-8945, 1349-4147
Related Report
Peer Reviewed / Open Access
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[Journal Article] Severe respiratory failure due to co-infection with human metapneumovirus and Streptococcus pneumoniae.2014
Author(s)
Seki M, Yoshida H, Gotoh K, Hamada N,Motooka D, Nakamura S, Yamamoto N, Hamaguchi S, Akeda Y, Watanabe H, Iida T, and Tomono K.
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Journal Title
Respiratory Medicine Case Reports
Volume: 12
Pages: 13-15
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Infection control for a methicillin-resistant Staphylococcus aureus outbreak in an advanced emergency medical service center, as monitored by molecular analysis.2013
Author(s)
Hidaka H, Miura M, Masunaga K, Qin L, Uemura Y, Sakai Y, Hashimoto K, Kawano S, Yamashita N, Sakamoto T, and Watanabe H.
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Journal Title
J Infect Chemother
Volume: 19
Issue: 5
Pages: 884-890
DOI
Related Report
Peer Reviewed
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[Journal Article] Determination of Epidemiology of Clinically Isolated <i>Cryptococcus neoformans</i> Strains in Japan by Multilocus Sequence Typing2013
Author(s)
Umeyama T, Ohno H, Minamoto F, Takagi T, Tanamachi C, Tanabe K, Kaneko Y, Yamagoe S, Kishi K, Fujii T, Takemura H, Watanabe H, Miyazaki Y.
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Journal Title
Japanese Journal of Infectious Diseases
Volume: 66
Issue: 1
Pages: 51-55
DOI
NAID
ISSN
1344-6304, 1884-2836
Related Report
Peer Reviewed
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[Presentation] 新興感染症の脅威と対応2014
Author(s)
渡邊 浩
Organizer
第42回日本救急医学会総会・学術集会
Place of Presentation
福岡国際会議場（福岡）
Year and Date
2014-10-29
Related Report
Invited
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[Presentation] Microbiological analysis of Corynebacterium spp. isolated from patients with nosocomial bacteremia.
Author(s)
Qin L, Bao R, Xie H, Sakai Y, Masunaga K, Hidaka H, Miura M, Hashimoto K, Tanamachi C, Hu B, and Watanabe H.
Organizer
The 6th International Congress of the Asia Pacific Society of Infection Control (APSIC).
Place of Presentation
Shanghai, China
Related Report
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